Results 91 to 100 of about 1,520,474 (347)

Maximin Optimal Designs for Cluster Randomized Trials [PDF]

Biometrics, 2017
SummaryWe consider design issues for cluster randomized trials (CRTs) with a binary outcome where both unit costs and intraclass correlation coefficients (ICCs) in the two arms may be unequal. We first propose a design that maximizes cost efficiency (CE), defined as the ratio of the precision of the efficacy measure to the study cost.
Wu, Sheng, Wong, Weng Kee, Crespi, Catherine M   +2 more
openaire   +4 more sources

The Effect of Helminth Infections and Their Treatment on Metabolic Outcomes: Results of a Cluster-Randomized Trial

Clinical Infectious Diseases, 2019
Background Helminths may protect against cardiometabolic risk through effects on inflammation and metabolism; their treatment may be detrimental to metabolic outcomes.
R. Sanya, E. Webb, Christopher Zziwa, R. Kizindo, Moses Sewankambo, Josephine Tumusiime, E. Nakazibwe, G. Oduru, Emmanuel Niwagaba, Prossy Kabuubi Nakawungu, J. Kabagenyi, J. Nassuuna, B. Walusimbi, Irene Andia-Biraro, A. Elliott   +14 more
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The Calculation of the 97.5% Upper Confidence Bound: Application to Clustered Binary Data in a Binomial Non-Inferiority Two-Sample Trial. [PDF]

, 2008
This paper will discuss the analysis of a cluster randomized binomial non-inferiority two-sample trial. The determination of the intra-cluster correlation coefficient (ICC) and its use in the calculation of the 97.5% upper confidence bound for delta, the
McCarthy, William F.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Cluster-randomized, controlled 12-month trial to evaluate the effect of a parental psychoeducation program on medication persistence in children with attention-deficit/hyperactivity disorder

Neuropsychiatric Disease and Treatment, 2014
Alonso Montoya,1 Amaia Hervás,2 Joaquín Fuentes,3 Esther Cardo,4 Pepa Polavieja,5 Javier Quintero,6 Rosemary Tannock7 1Medical Neurosciences, Lilly Research Laboratories Canada, Toronto, ON, Canada; 2Child and Adolescent Mental Health Unit,
Montoya A, Hervás A, Fuentes J, Cardo E, Polavieja P, Quintero J, Tannock R   +6 more
doaj  

Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials

Malaria Journal, 2019
Background Sample size calculations for cluster randomized trials are a recognized methodological challenge for malaria research in pre-elimination settings.
Pimnara Peerawaranun, Jordi Landier, Francois H. Nosten, Thuy-Nhien Nguyen, Tran Tinh Hien, Rupam Tripura, Thomas J. Peto, Koukeo Phommasone, Mayfong Mayxay, Nicholas P. J. Day, Arjen Dondorp, Nick White, Lorenz von Seidlein, Mavuto Mukaka   +13 more
doaj   +1 more source

The One Nutrition in Complex Environments (ONCE) study protocol: a cluster-randomized multi-level multi-sectoral intervention to improve nutrition in Uganda

Trials, 2022
Objective To implement and measure the effects of a multi-level multi-sectoral social behavior change (SBC) intervention in Agago District of Northern Uganda and to determine the potential for scale-up.
Stacy P. Griswold, Anastasia Marshak, Merry Fitzpatrick, Daniele Lantagne, Kate Shoenmakers, Marlene Hebie, Anne Radday, Hugo De Groote, Saurabh Mehta, Greg Gottlieb, Patrick Webb, Shibani Ghosh   +11 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Baseline and primary data for the partner-provided HIV self-testing and linkage (PASTAL) adaptive multi-arm multi-stage cluster randomized trial in Blantyre, Malawi [PDF]

, 2018
Dataset containing details of 2,349 pregnant women accessing antenatal care in three primary health centres in urban Blantyre, Malawi who gave informed consent to participate in an adaptive multi-arm multi-stage cluster randomized trial.
Choko, Augustine, Corbett, Elizabeth, Fielding, Katherine   +2 more
core   +1 more source