Results 101 to 110 of about 345,517 (350)

Raising the standard of applied dementia care research : addressing the implementation error [PDF]

, 2014
Editoria
Moniz-Cook, Esme, Vernooij-Dassen, Myrra
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effect of a Clinical Evidence Technology on Patient Skin Disease Outcomes in Primary Care: A Cluster-Randomized Controlled Trial [PDF]

, 2018
Objective: Providers’ use of clinical evidence technologies (CETs) improves their diagnosis and treatment decisions. Despite these benefits, few studies have evaluated the impact of CETs on patient outcomes. Investigators evaluated the effect of one CET,
Burke, Marianne, Littenberg, Benjamin, MD   +1 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Inappropriate Analysis of a Cluster Randomized Controlled Trial Due to Not Accounting for Nesting and Clustering: Comment on “A Home-Based Dyadic Music-with-Movement Intervention for People with Dementia and Caregivers: A Hybrid Type 2 Cluster-Randomized Effectiveness-Implementation Design” [Letter]

Clinical Interventions in Aging, 2023
Marleigh Hefner,1 Yasaman Jamshidi-Naeini,2 Colby J Vorland,2 Lilian Golzarri-Arroyo,2 Brian P Shaw,2 David B Allison2 1Department of Nutritional Sciences, Texas Tech University, Lubbock, TX, USA; 2Department of Epidemiology and Biostatistics, Indiana ...
Hefner M, Jamshidi-Naeini Y, Vorland CJ, Golzarri-Arroyo L, Shaw BP, Allison DB   +5 more
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Cluster randomized test-negative design (CR-TND) trials: a novel and efficient method to assess the efficacy of community level dengue interventions

, 2018
Cluster randomized trials are the gold standard for assessing efficacy of community-level interventions, such as vector control strategies against dengue.
Anders, KL, Cutcher, Z, Donnelly, CA, Ferguson, NM, Indriani, C, Jewell, NP, Kleinschmidt, I, O'Neill, SL, Ryan, PA, Simmons, CP   +9 more
core   +1 more source

Right To Play’s intervention to reduce peer violence among children in public schools in Pakistan: a cluster-randomized controlled trial [PDF]

, 2020
Rozina Karmaliani, Judith McFarlane, Hussain Maqbool Ahmed Khuwaja, Yasmeen Somani, Shireen Shehzad Bhamani, Tazeen Saeed Ali, Nargis Asad, Esnat Chirwa, Rachel Jewkes   +8 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Implementation strategies to integrate HIV and hypertension care in Kampala and Wakiso districts, Uganda: study protocol for a stepped wedge cluster randomized trial (PULESA-Uganda)

BMC Health Services Research
Background Hypertension (HTN) is the leading cause of cardiovascular morbidity and mortality among people living with HIV (PLWH) in Africa, yet integration of hypertension treatment in HIV clinics is sub-optimal.
Chris T. Longenecker, John Baptist Kiggundu, Florence Ayebare, Martin Muddu, James Kayima, Gerald Mutungi, Isaac Ssinabulya, Jeremy I. Schwartz, Donna Spiegelman, Guangyu Tong, Rachel Nugent, Angela Aifah, Faith Kagoya, Drew B. Cameron, Brian Hutchinson, Moses R. Kamya, Anne R. Katahoire, Fred C. Semitala   +17 more
doaj   +1 more source