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Cluster Randomized Trials

AAP Grand Rounds, 2011
Over the last century, the randomized clinical trial has become the gold standard for interventional studies. Typically individuals are randomly assigned to an experimental group or a control group. What if it was impractical or unethical to randomize individuals to a treatment group? This is where the cluster randomized trial design comes in.
Todd A. Florin, Samir S. Shah
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Balance in cluster randomized trials

Statistics in Medicine, 2001
This paper explores the role of balancing covariates between treatment groups in the design of cluster randomized trials. General expressions are obtained for two criteria to evaluate designs for parallel group studies with two treatments. The first is the variance of the estimated treatment effect and the second is the extent to which the estimated ...
G M, Raab, I, Butcher
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The Cluster Randomized Trial Study Design

AJN, American Journal of Nursing, 2023
Editor's note: This is the 17th article in a series on clinical research by nurses. The series is designed to be used as a resource for nurses to understand the concepts and principles essential to research. Each column will present the concepts that underpin evidence-based practice—from research design to data interpretation.
Bernadette, Capili, Joyce K, Anastasi
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Cluster Randomization Trials: A Simulation Study

Biometrical Journal, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Song, James X., Ahn, Chul
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Cluster randomized trials for HIV prevention

Current Opinion in HIV and AIDS, 2006
This paper reviews cluster randomized trials for HIV prevention, focusing on the unique aspects of such trials and describes key cluster randomized trials for HIV prevention from the past decade. Relevant methodological issues are also reviewed.Three cluster randomized trials evaluating sexually transmitted infection control as an HIV prevention tool ...
James P, Hughes, Michal, Kulich
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Cluster Randomized Trials

2023
Song Zhang, Chul Ahn, Hong Zhu
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Cluster-randomized trials: A closer look

Clinical Trials, 2016
Background: The cluster-randomized trial is the methodology of choice for evaluating interventions administered at the group level such as public health and healthcare quality improvement interventions. Because of unique features of this design, it can be difficult to apply standard research ethics guidelines to cluster-randomized trials.
Andrew D, McRae   +2 more
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Cluster Randomized Trials:Another Look

Hastings Center Report, 2013
The type of research known as cluster randomized trials raises ethical questions not readily answered within the standard understanding of research ethics. What distinguishes a CRT is that it randomizes at the level of social groups rather than at the level of individual research participants: in a CRT, the regimen under study might be assigned to a ...
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Cluster Randomized Clinical Trials

2017
This chapter discusses the design and analysis of cluster randomized clinical trials (CRCTs). These trials are useful when the intervention is most appropriately applied at a group level (e.g., provider, clinic, hospital). Since patients within a provider, clinic, or hospital are more likely to be similar than patients from another provider, clinic, or
openaire   +1 more source

Cluster randomization trials

Statistical Methods in Medical Research, 2000
A. Donner, N. Klar
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