Results 61 to 70 of about 1,520,474 (347)

Selection bias and subject refusal in a cluster-randomized controlled trial

BMC Medical Research Methodology, 2017
Background Selection bias and non-participation bias are major methodological concerns which impact external validity. Cluster-randomized controlled trials are especially prone to selection bias as it is impractical to blind clusters to their allocation ...
Rochelle Yang, Barry L. Carter, Tyler H. Gums, Brian M. Gryzlak, Yinghui Xu, Barcey T. Levy   +5 more
doaj   +1 more source

Cluster-randomized, crossover trial of head positioning in acute stroke [PDF]

, 2013
The role of supine positioning after acute stroke in improving cerebral blood flow and the countervailing risk of aspiration pneumonia have led to variation in head positioning in clinical practice.
Anderson, Craig, Arima, Hisatomi, Lavados, Pablo, Billot, Laurent, Hackett, Maree, Olavarria, Veronica, Munoz-Venturelli, Paula, Brunser, Alejandro, Peng, Bin, Cui, Liying, Song, Lily, Rogers, Kerrylee, Middleton, Sandy, Lim, Joyce Y., Forshaw, Denise, Lighbody, C. Elizabeth, Woodward, Mark, Pontes-Neto, Octavio, de Silva, H. Asita, Ruey-Tay, Lin, Lee, Tay H., Pandian, Jeyaraj, Mead, Gillian, Robinson, Thompson, Watkins, Caroline Leigh   +24 more
core   +5 more sources

A secondary analysis of the #Tamojunto cluster-randomized trial [PDF]

, 2019
Aims: To investigate the mediating effects of normative beliefs of drug use on the effects of the #Tamojunto school-based prevention program (Unplugged). Design: Secondary analysis of a cluster randomized controlled trial.
Cogo-Moreira, Hugo, Fidalgo, Thiago M., Leal, Ana Paula, Pimentel de Medeiros, Pollyanna Fausta de, Sanchez, Zila M., Valente, Juliana Y.   +5 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

BETTER HEALTH: Durham -- protocol for a cluster randomized trial of BETTER in community and public health settings

BMC Public Health, 2017
Background The Building on Existing Tools to Improve Chronic Disease Prevention and Screening (BETTER) cluster randomized trial in primary care settings demonstrated a 30% improvement in adherence to evidence-based Chronic Disease Prevention and ...
Lawrence Paszat, Rinku Sutradhar, Mary Ann O’Brien, Aisha Lofters, Andrew Pinto, Peter Selby, Nancy Baxter, Peter D. Donnelly, Regina Elliott, Richard H. Glazier, Robert Kyle, Donna Manca, Mary-Anne Pietrusiak, Linda Rabeneck, Nicolette Sopcak, Jill Tinmouth, Becky Wall, Eva Grunfeld   +17 more
doaj   +1 more source

Eliminating Monitor Overuse (EMO) type III effectiveness-deimplementation cluster-randomized trial: Statistical analysis plan

Contemporary Clinical Trials Communications, 2023
Background: Deimplementing overused health interventions is essential to maximizing quality and value while minimizing harm, waste, and inefficiencies. Three national guidelines discourage continuous pulse oximetry (SpO2) monitoring in children who are ...
Rui Xiao, Christopher P. Bonafide, Nathaniel J. Williams, Zuleyha Cidav, Christopher P. Landrigan, Jennifer Faerber, Spandana Makeneni, Courtney Benjamin Wolk, Amanda C. Schondelmeyer, Patrick W. Brady, Rinad S. Beidas, Enrique F. Schisterman   +11 more
doaj   +1 more source

Early Intervention for Diabetes in Medical and Surgical Inpatients Decreases Hyperglycemia and Hospital-Acquired Infections: A Cluster Randomized Trial

Diabetes Care, 2019
OBJECTIVE To investigate if early electronic identification and bedside management of inpatients with diabetes improves glycemic control in noncritical care.
M. Kyi, P. Colman, P. Wraight, J. Reid, A. Gorelik, A. Galligan, Shanal Kumar, Lois M. Rowan, Katie A. Marley, A. Nankervis, David M. Russell, S. Fourlanos   +11 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Implementation research on the intervention mode of “Comorbidity—Co-causes—Joint-prevention” comprehensive demonstration district of depression and obesity among children and adolescents in Beijing: study protocol

BMC Public Health
Background Depression and obesity among adolescents have become major public health problems. They have common biological mechanisms and overlapping risk factors, such as lack of exercise, poor diet, and sleep disorders.
Xinxin Wang, PingPing Gui, Junkang Lin, YanJie Zhao, Xiaorui Zhang, Yi Song, Linghui Meng   +6 more
doaj   +1 more source

Oxygen treatment for cluster headache attacks at different flow rates: a double-blind, randomized, crossover study

The Journal of Headache and Pain, 2018
Background Cluster headache attacks can, in many patients, be successfully treated with oxygen via a non-rebreather mask. In previous studies oxygen at flow rates of both 7 L/min and 12 L/min was shown to be effective.
Thijs H. T. Dirkx, Danielle Y. P. Haane, Peter J. Koehler   +2 more
doaj   +1 more source