Results 191 to 200 of about 1,957,946 (299)

Air pollution macro-regions identification using machine learning and spatio-temporal analysis. [PDF]

PLoS One
Morawiec T, Zareba M, Danek T, Chuchro M.   +3 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Integrative transcriptomic profiling reveals subtype-specific therapeutic vulnerabilities and resistance mechanisms in prostate cancer. [PDF]

BMC Cancer
Liu W, Kong W, Jiang S, Wei Y, Yu Z, Cao X, Yang J, Wei X, Shen L, Qin C, Zhu Q.   +10 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Data-driven frailty and reserve phenotypes in older outpatients: a cluster analysis of complementary geriatric assessment. [PDF]

Front Aging
Belfiori M, Salis F, Puxeddu B, Mulas M, Puligheddu M, Mandas A.   +5 more
europepmc   +1 more source

AGV-Integrated Noise-Aware Adaptive Clustering for Industrial Wireless Sensor Networks in smart factories

Ying Duan, Tian-Hui Fu, Lingling Li, Pasquale Pace, Gianluca Aloi, Giancarlo Fortino   +5 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Revealing intra-group immunotherapy response heterogeneity in metastatic urothelial carcinoma through interpretable feature extraction and spectral clustering. [PDF]

Front Immunol
Nagumo Y, Ye X, Shi T, Mathis BJ, Sakurai T, Nishiyama H.   +5 more
europepmc   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Distinct treatment response trajectories to allergen immunotherapy in allergic asthma and rhinitis: Insights from a multicenter study in routine clinical practice. [PDF]

World Allergy Organ J
Zhang P, Qin R, Zhang W, Yang Y, Li H, Dong X, He Y, Wang H, Chen Z, Chen L, Wu J, Bao Y, Tian M, Tan G, Ye J, Jin M, Liang Y, Xu K, Mao L, Lv Q, Zhang Y, Wang W, Li J.   +22 more
europepmc   +1 more source