Results 111 to 120 of about 27,554,683 (360)

Witnessing a merging bullet being stripped in the galaxy cluster, RXCJ2359.3-6042

open access: yes, 2015
We report the discovery of the merging cluster, RXCJ2359.3-6042, from the REFLEX II cluster survey and present our results from all three detectors combined in the imaging and spectral analysis of the XMM-Newton data.
Boehringer, Hans, Chon, Gayoung
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Cluster Analysis using Microgreographic data [PDF]

open access: yes
In this paper we try to identify manufacturing and service clusters in Spain, using data from Mercantile Registers of 2006. The proposed methodology partially follows contributions of Duranton and Overman (2005), Brenner (2003 and 2004) and Ellison and ...
Federico Pablo-Marti   +1 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Energy Poverty and Subjective Wellbeing: Empirical Analysis in Indonesia

open access: yesJurnal Ekonomi Pembangunan
As stated in the Sustainable Development Goals, energy poverty is a severe problem that is a priority for the United Nations to eradicate. In general, the study on energy poverty is concerned with objective indicators. More study still needs to evaluate
Zetara Zetara, Djoni Hartono
doaj   +1 more source

Using Multiple Decomposition Methods and Cluster Analysis to Find and Categorize Typical Patterns of EEG Activity in Motor Imagery Brain–Computer Interface Experiments [PDF]

open access: gold, 2020
Alexander Frolov   +6 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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