Results 91 to 100 of about 334,145 (360)

A website for cluster randomised trials including stepped wedge: facilitating quality trials and methodological research

Trials
Background A cluster randomised trial is a randomised controlled trial in which groups of individuals (clusters) are randomised to treatment arms.
Claire L. Chan, Clémence Leyrat, James Martin, Jennifer Thompson, Elizabeth L. Turner, Sandra M. Eldridge   +5 more
doaj   +1 more source

Time-efficient intervention to improve older adolescents’ cardiorespiratory fitness: findings from the ‘Burn 2 Learn’ cluster randomised controlled trial

British Journal of Sports Medicine, 2020
Background Cardiorespiratory fitness (CRF) is an important marker of current and future health status. The primary aim of our study was to evaluate the impact of a time-efficient school-based intervention on older adolescents’ CRF.
D. Lubans, Jordan J. Smith, N. Eather, A. Leahy, P. Morgan, C. Lonsdale, R. Plotnikoff, M. Nilsson, S. Kennedy, E. Holliday, Natasha Weaver, M. Noetel, T. Shigeta, M. Mavilidi, S. R. Valkenborghs, P. Gyawali, F. Walker, S. Costigan, C. Hillman   +18 more
semanticscholar   +1 more source

Assisted partner services for HIV in Kenya: a cluster randomised controlled trial [PDF]

The Lancet HIV, 2017
Assisted partner services for index patients with HIV infections involves elicitation of information about sex partners and contacting them to ensure that they test for HIV and link to care. Assisted partner services are not widely available in Africa.
Peter, Cherutich, Matthew R, Golden, Beatrice, Wamuti, Barbra A, Richardson, Kristjana H, Ásbjörnsdóttir, Felix A, Otieno, Ann, Ng'ang'a, Peter Maingi, Mutiti, Paul, Macharia, Betsy, Sambai, Matt, Dunbar, David, Bukusi, Carey, Farquhar   +12 more
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Supporting carers to manage pain medication in cancer patients at the end of life: A feasibility trial [PDF]

, 2017
Background: Carers of people with advanced cancer play a significant role in managing pain medication, yet they report insufficient information and support to do so confidently and competently. There is limited research evidence on the best ways for
Alison Richardson, Anderson BA, Bandura A, Bee P, Campbell NC, Carl May, Cleeland CS, Curran SL, Donovan HS, Elizabeth Lowson, Hopkinson J, Hudson PL, Jacki Hughes, Jane A Hughes, Jane B Hopkinson, Kazanowski M, Klepstad P, Lancaster G, Latter S, Latter S, Lawton J, Lazarus RS, Lee L, Letizia M, Lin C, Mehta A, Michael I Bennett, Moorey S, Oldham L, Patton MQ, Payne S, Peter Smith, Ritchie J, Robinson B, Sally Anstey, Schumacher K, Stone PC, Sue Duke, Sue Latter, Sygna K, Teunissen SCCM, Woodman C, Zeiss AM   +42 more
core   +5 more sources

High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial

The Lancet, 2018
Summary Background High-sensitivity cardiac troponin assays permit use of lower thresholds for the diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown.
Anoop S. V. Shah, A. Anand, F. Strachan, A. Ferry, K. Lee, A. Chapman, D. Sandeman, C. Stables, P. Adamson, J. Andrews, Mohamed S. Anwar, J. Hung, A. Moss, R. O'Brien, C. Berry, I. Findlay, S. Walker, A. Cruickshank, Alan Reid, A. Gray, P. Collinson, F. Apple, D. McAllister, D. Maguire, K. Fox, D. Newby, C. Tuck, R. Harkess, R. Parker, C. Keerie, C. Weir, N. Mills, Lucy Stacey D Takeshi Catalina A Athanasios Mischa Jean Marshall Stewart Fujisawa Vallejos Tsanas Hautvast, L. Marshall, S. Stewart, T. Fujisawa, C. Vallejos, A. Tsanas, M. Hautvast, J. McPherson, L. McKinlay, Jonathan Malo, C. Fischbacher, B. Croal, S. Leslie, A. Walker, Tony Wackett, Roma Armstrong, Laura Stirling, C. Macdonald, I. Sadat, F. Finlay, H. Charles, P. Linksted, Stephen Young, Bill Alexander, Chris F. Duncan   +56 more
semanticscholar   +1 more source

Effectiveness of a scalable group-based education and monitoring program, delivered by health workers, to improve control of hypertension in rural India: A cluster randomised controlled trial

PLoS Medicine, 2020
Background New methods are required to manage hypertension in resource-poor settings. We hypothesised that a community health worker (CHW)–led group-based education and monitoring intervention would improve control of blood pressure (BP).
D. Gamage, M. Riddell, R. Joshi, K. Thankappan, C. Chow, B. Oldenburg, R. Evans, A. Mahal, K. Kalyanram, K. Kartik, O. Suresh, N. Thomas, G. K. Mini, P. Maulik, V. Srikanth, S. Arabshahi, R. Varma, Rama Krishna Guggilla, F. D’Esposito, T. Sathish, M. Alim, A. Thrift   +21 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Reconciling research and implementation in micro health insurance experiments in India: study protocol for a randomized controlled trial

Trials, 2011
Background Microinsurance or Community-Based Health Insurance is a promising healthcare financing mechanism, which is increasingly applied to aid rural poor persons in low-income countries.
Doyle Conor, Panda Pradeep, Van de Poel Ellen, Radermacher Ralf, Dror David M   +4 more
doaj   +1 more source

An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial [PDF]

, 2015
Objective To evaluate the clinical efficacy of an established programme of occupational therapy in maintaining functional activity and reducing further health risks from inactivity in care home residents living with stroke sequelae.
Barton, Garry, Burton, C. R., Burton, Christopher R., Fletcher-Smith, J., Fletcher-Smith, Joanna, Irvine, L., Irvine, Lisa, Lett, K., Mant, J., Mant, Jonathan, Masterson-Algar, Patricia, Peryer, G., Peryer, Guy, Rashid, Farzana, Roalfe, A. K., Roalfe, Andrea K., Sackley, Catherine M., Sharp, L., Sharp, Leslie, Sheehan, B., Sheehan, Bart, Stant, K. E., Stant, Katie E., Steel, Kerry, Steele, K., Walker, M. F., Walker, Marion F., Watkins, C. L., Watkins, Caroline L., Wheatley, K., Wheatley, Keith, Wilde, K., Wilde, Kate, Williams, Jane   +33 more
core   +5 more sources