Results 91 to 100 of about 158,775 (308)

Health insurance and social capital in Ghana: a cluster randomised controlled trial [PDF]

Global Health Research and Policy, 2018
The National Health Insurance Scheme (NHIS) was introduced in Ghana in 2003, enrolment is still far from the desired target of universal coverage. Low community engagement in the design and management of the system was identified as one of the main barriers. The aim of the current study was to explore the role of social capital in NHIS enrolment in two
Christine J. Fenenga, Katalin Buzasi, Daniel K. Arhinful, Stephen K. O. Duku, Alice Ogink, Wouter Poortinga   +5 more
openaire   +5 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Prehospital Randomised Assessment of a Mechanical Compression Device In Cardiac Arrest (PaRAMeDIC) Trial Protocol [PDF]

, 2010
BACKGROUND Survival after out-of-hospital cardiac arrest is closely linked to the quality of CPR, but in real life, resuscitation during prehospital care and ambulance transport is often suboptimal.
Anne Slowther, Charles Deakin, Chris McCabe, Gavin D Perkins, Jessica Horton, Malcolm Woollard, Matthew W Cooke, Ranjit Lall, Sarah E Lamb, Simon Gates, Tom Quinn   +10 more
core   +5 more sources

Universal HIV testing in London tuberculosis clinics: a cluster randomised controlled trial [PDF]

European Respiratory Journal, 2012
We assessed whether implementation of a combination of interventions in London tuberculosis clinics raised the levels of HIV test offers, acceptance and coverage. A stepped-wedge cluster randomised controlled trial was conducted across 24 clinics.
Roy, A, Anaraki, S, Hardelid, P, Catchpole, M, Rodrigues, LC, Lipman, M, Perkins, S, Roche, A, Stagg, HR, Figueroa, J, Abubakar, I   +10 more
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes

BMC Medical Research Methodology, 2016
Background In an individually randomised controlled trial where the treatment is delivered by a health professional it seems likely that the effectiveness of the treatment, independent of any treatment effect, could depend on the skill, training or even ...
Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield, Stephen J. Walters   +5 more
doaj   +1 more source

Supporting carers to manage pain medication in cancer patients at the end of life: A feasibility trial [PDF]

, 2017
Background: Carers of people with advanced cancer play a significant role in managing pain medication, yet they report insufficient information and support to do so confidently and competently. There is limited research evidence on the best ways for
Alison Richardson, Anderson BA, Bandura A, Bee P, Campbell NC, Carl May, Cleeland CS, Curran SL, Donovan HS, Elizabeth Lowson, Hopkinson J, Hudson PL, Jacki Hughes, Jane A Hughes, Jane B Hopkinson, Kazanowski M, Klepstad P, Lancaster G, Latter S, Latter S, Lawton J, Lazarus RS, Lee L, Letizia M, Lin C, Mehta A, Michael I Bennett, Moorey S, Oldham L, Patton MQ, Payne S, Peter Smith, Ritchie J, Robinson B, Sally Anstey, Schumacher K, Stone PC, Sue Duke, Sue Latter, Sygna K, Teunissen SCCM, Woodman C, Zeiss AM   +42 more
core   +5 more sources

Workplace alcohol harm reduction intervention in Australia: Cluster non‐randomised controlled trial [PDF]

Drug and Alcohol Review, 2018
AbstractIntroduction and AimsThe workplace holds substantial potential as an alcohol harm reduction and prevention setting. Few studies have rigorously examined strategies to reduce workplace alcohol‐related harm. Hence, an in‐situ 3 year trial of a comprehensive alcohol harm reduction intervention in Australian manufacturing workplaces was undertaken ...
Ken Pidd, Ann Roche, Jacqui Cameron, Nicole Lee, Linda Jenner, Vinita Duraisingam   +5 more
openaire   +3 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A scoping review of the problems and solutions associated with contamination in trials of complex interventions in mental health

BMC Medical Research Methodology, 2019
Background In a randomised controlled trial, contamination is defined as the receipt of active intervention amongst participants in the control arm.
Nicholas Magill, Ruth Knight, Paul McCrone, Khalida Ismail, Sabine Landau   +4 more
doaj   +1 more source