Results 101 to 110 of about 158,775 (308)

Raising the standard of applied dementia care research : addressing the implementation error [PDF]

, 2014
Editoria
Moniz-Cook, Esme, Vernooij-Dassen, Myrra
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Intervention protocol: OPtimising thERapy to prevent avoidable hospital Admission in the Multi-morbid elderly (OPERAM): a structured medication review with support of a computerised decision support system

BMC Health Services Research, 2020
Background Several approaches to medication optimisation by identifying drug-related problems in older people have been described. Although some interventions have shown reductions in drug-related problems (DRPs), evidence supporting the effectiveness of
Erin K. Crowley, Bastiaan T. G. M. Sallevelt, Corlina J. A. Huibers, Kevin D. Murphy, Marco Spruit, Zhengru Shen, Benoît Boland, Anne Spinewine, Olivia Dalleur, Elisavet Moutzouri, Axel Löwe, Martin Feller, Nathalie Schwab, Luise Adam, Ingeborg Wilting, Wilma Knol, Nicolas Rodondi, Stephen Byrne, Denis O’Mahony   +18 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Effectiveness of an online training course to improve evidence-based leadership practices among unit leaders: study protocol for a cluster randomised two-arm controlled trial (EVILEAD)

Trials
Background A substantial knowledge base exists on how nurse leaders can support clinical staff in implementing evidence-based knowledge into practice. However, fewer studies are available on how leaders themselves learn and use evidence in their daily ...
Maritta Välimäki, Maija Satamo, Min Yang   +2 more
doaj   +1 more source

A comprehensive evaluation of the impact of telemonitoring in patients with long-term conditions and social care needs: protocol for the whole systems demonstrator cluster randomised trial [PDF]

, 2011
Background: It is expected that increased demands on services will result from expanding numbers of older people with long-term conditions and social care needs.
Adam Steventon, Anne Rogers, Caroline Sanders, Catherine Henderson, Helen Doll, James Barlow, Jane Hendy, Martin Bardsley, Martin Cartwright, Martin Knapp, Peter Bower, Raymond Fitzpatrick, Shashivadan P Hirani, Stanton Newman   +13 more
core   +5 more sources

Preventing suicidal behaviours with a multilevel intervention: a cluster randomised controlled trial [PDF]

BMC Public Health, 2018
In the context of the recent surge in community based multilevel interventions for suicide prevention, all of which show promising results, we discuss the implications of the findings of such an intervention designed for and implemented in New Zealand. The multi-level intervention for suicide prevention in New Zealand (MISP-NZ) was a cluster randomised
Collings, Sunny, Jenkin, Gabrielle, Stanley, James, McKenzie, Sarah, Hatcher, Simon   +4 more
openaire   +4 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Coverage and beliefs about temephos application for control of dengue vectors and impact of a community-based prevention intervention: secondary analysis from the Camino Verde trial in Mexico

BMC Public Health, 2017
Background Temephos in domestic water containers remains a mainstay of Latin American government programmes for control of Aedes aegypti and associated illnesses, including dengue.
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipé René Serrano de los Santos, Belén Madeline Sánchez-Gervacio, Robert J. Ledogar, Anne Cockcroft, Neil Andersson   +8 more
doaj   +1 more source