Results 111 to 120 of about 334,145 (360)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

An empowerment programme to improve diet quality during pregnancy – the Power 4 a Healthy Pregnancy cluster randomised controlled trial

BMC Public Health
Background A healthy diet during pregnancy is vital for the well-being of both mothers and babies. However, navigating dietary choices amidst the unique psychological and physiological changes of pregnancy can be challenging.
Renske M. van Lonkhuijzen, Jeanne H. M. de Vries, Elske Brouwer-Brolsma, Susanne Cremers, Janine P. M. Faessen, Edith J. M. Feskens, Annemarie Wagemakers   +6 more
doaj   +1 more source

Intervention protocol: OPtimising thERapy to prevent avoidable hospital Admission in the Multi-morbid elderly (OPERAM): a structured medication review with support of a computerised decision support system

BMC Health Services Research, 2020
Background Several approaches to medication optimisation by identifying drug-related problems in older people have been described. Although some interventions have shown reductions in drug-related problems (DRPs), evidence supporting the effectiveness of
Erin K. Crowley, Bastiaan T. G. M. Sallevelt, Corlina J. A. Huibers, Kevin D. Murphy, Marco Spruit, Zhengru Shen, Benoît Boland, Anne Spinewine, Olivia Dalleur, Elisavet Moutzouri, Axel Löwe, Martin Feller, Nathalie Schwab, Luise Adam, Ingeborg Wilting, Wilma Knol, Nicolas Rodondi, Stephen Byrne, Denis O’Mahony   +18 more
doaj   +1 more source

A cluster randomised trial of a Needs Assessment Tool for adult Cancer patients and their carers (NAT-C) in primary care: A feasibility study.

PLoS ONE, 2021
BackgroundPeople with cancer often have unidentified symptoms and social care needs. The Needs Assessment Tool-Cancer (NAT-C) is a validated, structured method of assessing patient/carer concerns and prompting action, to address unmet need.AimsAssess ...
Joseph Clark, Elvis Amoakwa, Alexandra Wright-Hughes, John Blenkinsopp, David C Currow, David Meads, Amanda Farrin, Victoria Allgar, Una Macleod, Miriam Johnson   +9 more
doaj   +1 more source

A study protocol for a cluster-randomised controlled trial of smartphone-activated first responders with ultraportable defibrillators in out-of-hospital cardiac arrest: The First Responder Shock Trial (FIRST)

Resuscitation Plus, 2023
Objective: To describe the First Responder Shock Trial (FIRST), which aims to determine whether equipping frequently responding, smartphone-activated (GoodSAM) first responders with an ultraportable AED can increase 30-day survival rates in OHCA. Methods:
Verity Todd, Bridget Dicker, Daniel Okyere, Karen Smith, Tony Smith, Graham Howie, Dion Stub, Michael Ray, Ralph Stewart, Tony Scott, Andy Swain, Natalie Heriot, Aroha Brett, Emily Mahony, Ziad Nehme   +14 more
doaj   +1 more source

Cascade diagrams for depicting complex interventions in randomised trials [PDF]

, 2013
Many medical interventions—particularly non-pharmacological ones—are complex, consisting of multiple interacting components targeted at different organisational levels.1 2 Published descriptions of complex interventions often do not contain enough ...
Bremner, Stephen A., Eldridge, Sandra, Froud, Robert J., Hooper, R., Perera, R.   +4 more
core   +1 more source

The effectiveness and cost-effectiveness of strength and balance Exergames to reduce falls risk for people aged 55 years and older in UK assisted living facilities: a multi-centre, cluster randomised controlled trial

BMC Medicine, 2019
BackgroundFalls are the leading cause of fatal and non-fatal unintentional injuries in older people. The use of Exergames (active, gamified video-based exercises) is a possible innovative, community-based approach.
E. Stanmore, A. Mavroeidi, Lex D. de Jong, D. Skelton, C. Sutton, Valerio Benedetto, Luke Munford, Wytske Meekes, V. Bell, C. Todd   +9 more
semanticscholar   +1 more source

Opportunistic screening versus usual care for detection of atrial fibrillation in primary care: cluster randomised controlled trial

British medical journal, 2020
Objective To investigate whether opportunistic screening in primary care increases the detection of atrial fibrillation compared with usual care. Design Cluster randomised controlled trial.
S. Uittenbogaart, N. Verbiest-van Gurp, W. Lucassen, B. Winkens, M. Nielen, P. Erkens, J. Knottnerus, H. V. van Weert, H. Stoffers   +8 more
semanticscholar   +1 more source

Health insurance and social capital in Ghana: a cluster randomised controlled trial [PDF]

Global Health Research and Policy, 2018
The National Health Insurance Scheme (NHIS) was introduced in Ghana in 2003, enrolment is still far from the desired target of universal coverage. Low community engagement in the design and management of the system was identified as one of the main barriers. The aim of the current study was to explore the role of social capital in NHIS enrolment in two
Christine J. Fenenga, Katalin Buzasi, Daniel K. Arhinful, Stephen K. O. Duku, Alice Ogink, Wouter Poortinga   +5 more
openaire   +5 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source