Results 131 to 140 of about 158,775 (308)

Ethical issues in the design and conduct of cluster randomised controlled trials

BMJ, 1999
In most randomised controlled trials, individual patients are randomised to a treatment or control group, but sometimes this is undesirable or even impossible and groups (clusters) of people may be randomised instead. These are called cluster randomised controlled trials, and although they have been around for a long time, the need for them is likely ...
S J, Edwards, D A, Braunholtz, R J, Lilford, A J, Stevens   +3 more
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Cascade diagrams for depicting complex interventions in randomised trials [PDF]

, 2013
Many medical interventions—particularly non-pharmacological ones—are complex, consisting of multiple interacting components targeted at different organisational levels.1 2 Published descriptions of complex interventions often do not contain enough ...
Bremner, Stephen A., Eldridge, Sandra, Froud, Robert J., Hooper, R., Perera, R.   +4 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Developing and testing accelerated partner therapy for partner notification for people with genital Chlamydia trachomatis diagnosed in primary care: a pilot randomised controlled trial [PDF]

, 2015
Background Accelerated partner therapy (APT) is a promising partner notification (PN) intervention in specialist sexual health clinic attenders. To address its applicability in primary care, we undertook a pilot randomised controlled trial (RCT) of two
Althaus, Andrew Copas, Anne M Johnson, Bailey, Cassell, Catherine H Mercer, Centers for Disease Control and Prevention, Chen, Claudia S Estcourt, Cowan, Estcourt, Estcourt, Ferreira, Greta Rait, Götz, Jackie A Cassell, Kazeem Aderogba, Laura Tickle, Lorna J Sutcliffe, Louise J Jackson, Low, Low, McCarney, McNulty, McNulty, McNulty, Mercer, Mercer, Mercer, Merle Symonds, Miller, Pamela Muniina, Roberts, Sarah Creighton, Shackleton, Tracy E Roberts, Turner   +36 more
core   +6 more sources

A community-based cluster randomised controlled trial in rural Bangladesh to evaluate the impact of the use of iron-folic acid supplements early in pregnancy on the risk of neonatal mortality: the Shonjibon trial

BMC Public Health, 2018
Background Iron-deficiency is the most common nutritional deficiency globally. Due to the high iron requirements for pregnancy, it is highly prevalent and severe in pregnant women.
Tanvir M. Huda, Mohammad Masudur Rahman, Shahreen Raihana, Sajia Islam, Tazeen Tahsina, Ashraful Alam, Kingsley Agho, Sabrina Rasheed, Alison Hayes, Mohd Anisul Karim, Qazi Sadequr Rahman, Abu Bakkar Siddique, Md Moinuddin, Morseda Chowdhury, Lucky Ghose, Kaosar Afsana, Camille Raynes-Greenow, Shams El Arifeen, Michael J. Dibley   +18 more
doaj   +1 more source

Effects of a standard provision versus an autonomy supportive exercise referral programme on physical activity, quality of life and well-being indicators:a cluster randomised controlled trial [PDF]

, 2014
Background: The National Institute for Health and Clinical Excellence in the UK has recommended that the effectiveness of ongoing exercise referral schemes to promote physical activity should be examined in research trials.
Blamey, Ruth V, Daley, Amanda, Duda, Joan L, Eves, Frank F, Jolly, Kate, Lodhia, Rekha, Mutrie, Nanette, Ntoumanis, Nikos, Rouse, Peter C, Williams, Geoffrey C   +9 more
core   +6 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

An Occupational Therapy intervention for residents with stroke-related disabilities in UK Care Homes (OTCH): cluster randomised controlled trial with economic evaluation

Health Technology Assessment, 2016
Background: Care home residents with stroke-related disabilities have significant activity limitations. Phase II trial results suggested a potential benefit of occupational therapy (OT) in maintaining residents’ capacity to engage in functional activity.
Catherine M Sackley, Marion F Walker, Christopher R Burton, Caroline L Watkins, Jonathan Mant, Andrea K Roalfe, Keith Wheatley, Bart Sheehan, Leslie Sharp, Katie E Stant, Joanna Fletcher-Smith, Kerry Steel, Garry R Barton, Lisa Irvine, Guy Peryer, on behalf of the OTCH investigators   +15 more
doaj   +1 more source