Results 131 to 140 of about 334,145 (360)

Rationale, design and methods of the Study of Work and Pain (SWAP): a cluster randomised controlled trial testing the addition of a vocational advice service to best current primary care for patients with musculoskeletal pain (ISRCTN 52269669) [PDF]

, 2014
Background Musculoskeletal pain is a major contributor to short and long term work absence. Patients seek care from their general practitioner (GP) and yet GPs often feel ill-equipped to deal with work issues.
A Kim Burton, A Mowlam, A Strauss, Annette Bishop, B McGuirk, C Black, Cabinet Office, Chris Main, CM Stapelfeldt, Danielle van der Windt, Department for Business Enterprise and Regulatory Reform, Department of Health, Department of Health, Health and Safety Executive, Department for Work and Pensions, Elaine M Hay, G Adams, G Waddell, G Waddell, G Waddell, G Waddell, G Waddell, G Waddell, G Waddell, Gail Sowden, Gwenllian Wynne-Jones, Health and Safety Executive, Health and Safety Executive, J Hiscock, JC Hill, K Kroenke, K Nice, K Nice, L Curtis, M Hann, M Lewis, M Van Tulder, MA Hanson, Martyn Lewis, Nadine E Foster, NAS Kendall, National Institute for Health and Clinical Excellence, Office for National Statistics, Office for National Statistics, PJ Watson, R Buchbinder, RJ Hayes, RL Franche, Sarah A Lawton, SM Eldridge, Sue Jowett, Tom Sanders, W Weidenhammer, WS Shaw   +51 more
core   +3 more sources

The clinical and cost-effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime (the VIP trial): study protocol for a randomised controlled trial. [PDF]

, 2020
BACKGROUND: Older people are vulnerable to sustained high levels of psychosocial distress following a crime. A cognitive behavioural therapy (CBT)-informed psychological therapy, the Victim Improvement Package (VIP) may aid recovery.
Andrew, D, Aspden, T, Blanchard, M, Brewin, CR, Buszewicz, M, Cuming-Higgs, J, Drennan, V, Hunter, R, Kessel, A, Laycock, G, Leavey, G, O'Keeffe, A, Riveros, M, Satchell, J, Serfaty, M   +14 more
core   +6 more sources

Impact of Stepping Stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa: cluster randomised controlled trial

British medical journal, 2008
Objective To assess the impact of Stepping Stones, a HIV prevention programme, on incidence of HIV and herpes simplex type 2 (HSV-2) and sexual behaviour. Design Cluster randomised controlled trial.
R. Jewkes, M. Nduna, J. Levin, N. Jama, K. Dunkle, A. Puren, N. Duvvury   +6 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Effectiveness of an online training course to improve evidence-based leadership practices among unit leaders: study protocol for a cluster randomised two-arm controlled trial (EVILEAD)

Trials
Background A substantial knowledge base exists on how nurse leaders can support clinical staff in implementing evidence-based knowledge into practice. However, fewer studies are available on how leaders themselves learn and use evidence in their daily ...
Maritta Välimäki, Maija Satamo, Min Yang   +2 more
doaj   +1 more source

Preventing and lessening exacerbations of asthma in school-age children associated with a new term (PLEASANT) : Study protocol for a cluster randomised control trial [PDF]

, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Boote, Jonathan, Bradburn, Mike J., Cooper, Cindy L., Davis, Sarah, Elphick, Heather, Horspool, Michelle J., Julious, Steven A., Norman, Paul, Smithson, W. H., vanStaa, Tjeerd   +9 more
core   +4 more sources

Preventing suicidal behaviours with a multilevel intervention: a cluster randomised controlled trial [PDF]

BMC Public Health, 2018
In the context of the recent surge in community based multilevel interventions for suicide prevention, all of which show promising results, we discuss the implications of the findings of such an intervention designed for and implemented in New Zealand. The multi-level intervention for suicide prevention in New Zealand (MISP-NZ) was a cluster randomised
Collings, Sunny, Jenkin, Gabrielle, Stanley, James, McKenzie, Sarah, Hatcher, Simon   +4 more
openaire   +4 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Coverage and beliefs about temephos application for control of dengue vectors and impact of a community-based prevention intervention: secondary analysis from the Camino Verde trial in Mexico

BMC Public Health, 2017
Background Temephos in domestic water containers remains a mainstay of Latin American government programmes for control of Aedes aegypti and associated illnesses, including dengue.
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipé René Serrano de los Santos, Belén Madeline Sánchez-Gervacio, Robert J. Ledogar, Anne Cockcroft, Neil Andersson   +8 more
doaj   +1 more source

Randomised controlled trials of complex interventions and large-scale transformation of services [PDF]

, 2016
Complex interventions and large-scale transformations of services are necessary to meet the health-care challenges of the 21st century. However, the evaluation of these types of interventions is challenging and requires methodological development ...
Barratt, Helen, Bower, Peter, Campbell, Marion, Moore, Laurence, Zwarenstein, Merrick   +4 more
core   +1 more source