Results 141 to 150 of about 334,145 (360)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A scoping review of the problems and solutions associated with contamination in trials of complex interventions in mental health

BMC Medical Research Methodology, 2019
Background In a randomised controlled trial, contamination is defined as the receipt of active intervention amongst participants in the control arm.
Nicholas Magill, Ruth Knight, Paul McCrone, Khalida Ismail, Sabine Landau   +4 more
doaj   +1 more source

The impact of training non-physician clinicians in Malawi on maternal and perinatal mortality : a cluster randomised controlled evaluation of the enhancing training and appropriate technologies for mothers and babies in Africa (ETATMBA) project [PDF]

, 2012
Background: Maternal mortality in much of sub-Saharan Africa is very high whereas there has been a steady decline in over the past 60 years in Europe. Perinatal mortality is 12 times higher than maternal mortality accounting for about 7 million neonatal
A Wilson, C McCord, C Pereira, C Pereira, C Pope, Chisale Mhango, D Ellard, David Davies, David Ellard, Doug Simkiss, E McAuliffe, F Mullan, Francis Kamwendo, G Chilopora, J Bryce, J Ritchie, Joseph Paul O’Hare, K Hill, Ministry of Health, National Statistical Office (NSO), and ICF Macro, Ngianga-bakwin Kandala, S Bergstrom, S Bradley, S Niermeyer, Siobhan Quenby, W Graham, W Graham, World Health Organization, UNICEF, UNFPA, and The World Bank   +27 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Are randomised controlled trials positivist? Reviewing the social science and philosophy literature to assess positivist tendencies of trials of social interventions in public health and health services [PDF]

, 2018
Background: We have previously proposed that trials of social interventions can be done within a ‘realist’ research paradigm. Critics have countered that such trials are irredeemably positivist and asked us to explain our philosophical position ...
Bonell, Chris, Moore, Graham, Moore, Laurence, Warren, Emily   +3 more
core   +4 more sources

Comprehensive warm-up programme to prevent injuries in young female footballers: cluster randomised controlled trial

British medical journal, 2008
Objective To examine the effect of a comprehensive warm-up programme designed to reduce the risk of injuries in female youth football. Design Cluster randomised controlled trial with clubs as the unit of randomisation. Setting 125 football clubs from the
T. Soligard, G. Myklebust, K. Steffen, I. Holme, H. Silvers, M. Bizzini, A. Junge, J. Dvořák, R. Bahr, T. Andersen   +9 more
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A collaborative care psychosocial intervention to improve late life depression in socioeconomically deprived areas of Guarulhos, Brazil: the PROACTIVE cluster randomised controlled trial protocol

Trials, 2020
Background The elderly population has been growing in most low- and middle-income countries (LMIC), and depression is a common condition among these populations.
Marcia Scazufca, Carina Akemi Nakamura, Tim J. Peters, Maiara Garcia Henrique, Antônio Seabra, Ehidee Gomez La Rotta, Renato M. Franzin, Daniele Ferreira Martins, Pepijn Van de Ven, William Hollingworth, Ricardo Araya   +10 more
doaj   +1 more source

Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial

British medical journal, 2018
Objectives To evaluate the impact of a multicomponent intervention (Stand More AT (SMArT) Work) designed to reduce sitting time on short (three months), medium (six months), and longer term (12 months) changes in occupational, daily, and prolonged ...
C. Edwardson, T. Yates, S. Biddle, M. Davies, D. Dunstan, D. Esliger, L. Gray, B. Jackson, S. O'Connell, Ghazala Waheed, F. Munir   +10 more
semanticscholar   +1 more source

Effect of collaborative care between traditional and faith healers and primary health-care workers on psychosis outcomes in Nigeria and Ghana (COSIMPO): a cluster randomised controlled trial.

The Lancet, 2020
BACKGROUND Traditional and faith healers (TFH) provide care to a large number of people with psychosis in many sub-Saharan African countries but they practise outside the formal mental health system.
O. Gureje, J. Appiah-Poku, Toyin Bello, Lola Kola, S. Seedat   +4 more
semanticscholar   +1 more source