Results 171 to 180 of about 334,145 (360)

Effects, equity, and cost of school-based and community-wide treatment strategies for soil-transmitted helminths in Kenya: a cluster-randomised controlled trial

The Lancet, 2019
Summary Background School-based deworming programmes can reduce morbidity attributable to soil-transmitted helminths in children but do not interrupt transmission in the wider community. We assessed the effects of alternative mass treatment strategies on
R. Pullan, K. Halliday, William E. Oswald, Carlos Mcharo, E. Beaumont, S. Kepha, S. Witek-Mcmanus, P. Gichuki, E. Allen, T. Drake, C. Pitt, S. Matendechero, Marie-Claire Gwayi-Chore, R. Anderson, S. Njenga, S. Brooker, C. Mwandawiro   +16 more
semanticscholar   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Sexually transmitted infection as a risk factor for homosexual HIV transmission: a systematic review of epidemiological studies

, 2000
Existing reviews suggest some sexually transmitted infections (STIs) are risk factors in heterosexual HIV transmission. This may not be so in homosexual HIV transmission, about which reviews make no specific conclusions.
Bonell, C, Hickson, F, Weatherburn, P
core   +1 more source

Bypassing nearest hospital for more distant neuroscience care in head-injured adults with suspected traumatic brain injury: findings of the head injury transportation straight to neurosurgery (HITS-NS) pilot cluster randomised trial [PDF]

, 2017
OBJECTIVE: Reconfiguration of trauma services, with direct transport of patients with traumatic brain injury (TBI) to specialist neuroscience centres (SNCs)-bypassing non-specialist acute hospitals (NSAHs), could improve outcomes.
Byers, S., Chapman, N., Coats, T., Curran, A., Freeman, J., Fuller, G., Goodacre, S.., Han, K., Holliman, D., Lecky, F.E., Mackway-Jones, K., Mason, S., McClelland, G., Pennington, E., Peters, M., Potter, H., Russell, W., Shewan, J.   +17 more
core   +1 more source

Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial.

The Lancet, 2016
BACKGROUND Cardiovascular risk factors are associated with an increased risk of dementia. We assessed whether a multidomain intervention targeting these factors can prevent dementia in a population of community-dwelling older people.
E. P. Moll van Charante, E. Richard, L. Eurelings, J. V. van Dalen, S. Ligthart, E. V. van Bussel, M. Hoevenaar-Blom, M. Vermeulen, W. V. van Gool   +8 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A community-based cluster randomised controlled trial in rural Bangladesh to evaluate the impact of the use of iron-folic acid supplements early in pregnancy on the risk of neonatal mortality: the Shonjibon trial

BMC Public Health, 2018
Background Iron-deficiency is the most common nutritional deficiency globally. Due to the high iron requirements for pregnancy, it is highly prevalent and severe in pregnant women.
Tanvir M. Huda, Mohammad Masudur Rahman, Shahreen Raihana, Sajia Islam, Tazeen Tahsina, Ashraful Alam, Kingsley Agho, Sabrina Rasheed, Alison Hayes, Mohd Anisul Karim, Qazi Sadequr Rahman, Abu Bakkar Siddique, Md Moinuddin, Morseda Chowdhury, Lucky Ghose, Kaosar Afsana, Camille Raynes-Greenow, Shams El Arifeen, Michael J. Dibley   +18 more
doaj   +1 more source

Staff-led interventions for improving oral hygiene in patients following stroke [PDF]

, 2010
Background For people with limitations due to neurological conditions such as stroke, the routine practice of oral care may become a challenge. Evidence-based supported oral care intervention is essential for this patient group. Objectives To compare the
Brady, Marian C., Furlanetto, Denise, Hunter, Romana, Lewis, Steff C., Milne, Vikki   +4 more
core   +3 more sources

The Adductor Strengthening Programme prevents groin problems among male football players: a cluster-randomised controlled trial

British Journal of Sports Medicine, 2018
Background Groin injuries represent a considerable problem in male football. Previous groin-specific prevention programmes have not shown a significant reduction in groin injury rates.
Joar Harøy, B. Clarsen, Espen Guldahl Wiger, Mari Glomnes Øyen, A. Serner, K. Thorborg, P. Hölmich, T. Andersen, R. Bahr   +8 more
semanticscholar   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source