Results 91 to 100 of about 175,554 (303)

An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial [PDF]

, 2015
Objective To evaluate the clinical efficacy of an established programme of occupational therapy in maintaining functional activity and reducing further health risks from inactivity in care home residents living with stroke sequelae.
Barton, Garry, Burton, C. R., Burton, Christopher R., Fletcher-Smith, J., Fletcher-Smith, Joanna, Irvine, L., Irvine, Lisa, Lett, K., Mant, J., Mant, Jonathan, Masterson-Algar, Patricia, Peryer, G., Peryer, Guy, Rashid, Farzana, Roalfe, A. K., Roalfe, Andrea K., Sackley, Catherine M., Sharp, L., Sharp, Leslie, Sheehan, B., Sheehan, Bart, Stant, K. E., Stant, Katie E., Steel, Kerry, Steele, K., Walker, M. F., Walker, Marion F., Watkins, C. L., Watkins, Caroline L., Wheatley, K., Wheatley, Keith, Wilde, K., Wilde, Kate, Williams, Jane   +33 more
core   +5 more sources

Rojiroti microfinance and child nutrition: a cluster randomised trial [PDF]

Archives of Disease in Childhood, 2019
ObjectiveTo determine whether Rojiroti microfinance, for poor Indian women, improves child nutrition.DesignCluster randomised trial.SettingTolas (village communities) in Bihar State.ParticipantsWomen and children under 5 years.InterventionsWith Rojiroti microfinance, women form self-help groups and save their money to provide loans to group members ...
Shalini Ojha, Lisa Szatkowski, Ranjeet Sinha, Gil Yaron, Andrew Fogarty, Stephen John Allen, Sunil Choudhary, Alan Robert Smyth   +7 more
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Community perspectives on randomisation and fairness in a cluster randomised controlled trial in Zambia

BMC Medical Ethics, 2019
Background One important ethical issue in randomised controlled trials (RCTs) is randomisation. Relatively little is known about how participating individuals and communities understand and perceive central aspects of randomisation such as equality ...
Maureen Mupeta Kombe, Joseph Mumba Zulu, Charles Michelo, Ingvild F. Sandøy   +3 more
doaj   +1 more source

TRial to Assess Implementation of New research in a primary care Setting (TRAINS): study protocol for a pragmatic cluster randomised controlled trial of an educational intervention to promote asthma prescription uptake in general practitioner practices

Trials, 2022
Background There is a marked increase in unscheduled care visits in school-aged children with asthma after returning to school in September. This is potentially associated with children not taking their asthma preventer medication during the school ...
Rami A. Alyami, Rebecca Simpson, Phillip Oliver, Steven A. Julious   +3 more
doaj   +1 more source

Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction [PDF]

, 2011
<b>Background</b> Meta-analysis of small trials suggests that pharmacist-led collaborative review and revision of medical treatment may improve outcomes in heart failure.<p></p> <b>Methods and results</b> We studied
Forsyth, P., Greenlaw, N., Jhund, P.S., Lowrie, R., Mair, F.S., McConnachie, A., McMurray, J.J.V., Rae, B.   +7 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Sustainable waiting time reductions after introducing the STAT model for access and triage: 12-month follow up of a stepped wedge cluster randomised controlled trial

BMC Health Services Research, 2020
Background Timely access is a challenge for providers of outpatient and community-based health services, as seen by the often lengthy waiting lists to manage demand.
Katherine E. Harding, David A. Snowdon, Luke Prendergast, Annie K. Lewis, Bridie Kent, Sandy F. Leggat, Nicholas F. Taylor   +6 more
doaj   +1 more source

Implementing telephone triage in general practice: a process evaluation of a cluster randomised controlled trial [PDF]

, 2015
Background: Telephone triage represents one strategy to manage demand for face-to-face GP appointments in primary care. However, limited evidence exists of the challenges GP practices face in implementing telephone triage.
A Fretheim, Anna Varley, B McKinstry, B McKinstry, C Pope, C Pope, Chris Salisbury, Colin Green, CR May, D Richards, DA Richards, David A Richards, Emily Fletcher, H Boon, I Holmstrom, J Green, J Murdoch, Jamie Murdoch, John L Campbell, Linnie Price, LS Meredith, M Jiwa, NB Baskerville, NC Campbell, Nicky Britten, P Craig, P Hawe, Raff Calitri, Rod S Taylor, RP Hermens, S Flottorp, SR Poole, Suzanne H Richards, V Lattimer, Valerie Lattimer   +34 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source