Results 91 to 100 of about 177,882 (303)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

TRial to Assess Implementation of New research in a primary care Setting (TRAINS): study protocol for a pragmatic cluster randomised controlled trial of an educational intervention to promote asthma prescription uptake in general practitioner practices

Trials, 2022
Background There is a marked increase in unscheduled care visits in school-aged children with asthma after returning to school in September. This is potentially associated with children not taking their asthma preventer medication during the school ...
Rami A. Alyami, Rebecca Simpson, Phillip Oliver, Steven A. Julious   +3 more
doaj   +1 more source

Preventing and lessening exacerbations of asthma in school-age children associated with a new term (PLEASANT) : Study protocol for a cluster randomised control trial [PDF]

, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Boote, Jonathan, Bradburn, Mike J., Cooper, Cindy L., Davis, Sarah, Elphick, Heather, Horspool, Michelle J., Julious, Steven A., Norman, Paul, Smithson, W. H., vanStaa, Tjeerd   +9 more
core   +4 more sources

Rojiroti microfinance and child nutrition: a cluster randomised trial [PDF]

Archives of Disease in Childhood, 2019
ObjectiveTo determine whether Rojiroti microfinance, for poor Indian women, improves child nutrition.DesignCluster randomised trial.SettingTolas (village communities) in Bihar State.ParticipantsWomen and children under 5 years.InterventionsWith Rojiroti microfinance, women form self-help groups and save their money to provide loans to group members ...
Shalini Ojha, Lisa Szatkowski, Ranjeet Sinha, Gil Yaron, Andrew Fogarty, Stephen John Allen, Sunil Choudhary, Alan Robert Smyth   +7 more
openaire   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Community perspectives on randomisation and fairness in a cluster randomised controlled trial in Zambia

BMC Medical Ethics, 2019
Background One important ethical issue in randomised controlled trials (RCTs) is randomisation. Relatively little is known about how participating individuals and communities understand and perceive central aspects of randomisation such as equality ...
Maureen Mupeta Kombe, Joseph Mumba Zulu, Charles Michelo, Ingvild F. Sandøy   +3 more
doaj   +1 more source

Sustainable waiting time reductions after introducing the STAT model for access and triage: 12-month follow up of a stepped wedge cluster randomised controlled trial

BMC Health Services Research, 2020
Background Timely access is a challenge for providers of outpatient and community-based health services, as seen by the often lengthy waiting lists to manage demand.
Katherine E. Harding, David A. Snowdon, Luke Prendergast, Annie K. Lewis, Bridie Kent, Sandy F. Leggat, Nicholas F. Taylor   +6 more
doaj   +1 more source

Ethical issues in implementation research: a discussion of the problems in achieving informed consent [PDF]

, 2008
Background: Improved quality of care is a policy objective of health care systems around the world. Implementation research is the scientific study of methods to promote the systematic uptake of clinical research findings into routine clinical practice ...
A Iversen, A Vahratian, American Statistical Association, B Briesacher, B Woodward, C Junghans, C Verity, Council of the International Organisation of Medical Sciences, D Raffe, H Ward, International Statistical Institute, J Grimshaw, J Tu, Jane L Hutton, Jeremy M Grimshaw, JL Hutton, JL Hutton, L Doyal, M Eccles, M Eccles, M Eccles, M Robling, M Thompson, Martin P Eccles, MP Eccles, MRC ethics series, R Baker, R Foy, R Grol, R Winkelmann, RE Ashcroft, RE Ashcroft, Royal Statistical Society, S Blackstone, S Rogerson, S Woolf, SJL Edwards, T Beauchap, T Walley, World Medical Association Declaration of Helsinki   +39 more
core   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Inadequate reporting of research ethics review and informed consent in cluster randomized trials : review of random sample of published trials [PDF]

, 2011
Peer reviewedPublisher ...
Bennett, Carol, Boruch, Robert F, Brehaut, Jamie C, Dixon, Stephanie, Donner, Allan, Eccles, Martin P, Grimshaw, Jeremy M, McRae, Andrew D, Saginur, Raphael, Skea, Zoe, Taleban, Julia, Taljaard, Monica, Weijer, Charles   +12 more
core   +2 more sources