Results 111 to 120 of about 177,882 (303)

Managing Injuries of the Neck Trial (MINT): design of a randomised controlled trial of treatments for whiplash associated disorders

BMC Musculoskeletal Disorders, 2007
Background A substantial proportion of patients with whiplash injuries develop chronic symptoms. However, the best treatment of acute injuries to prevent long-term problems is uncertain.
Williamson Esther M, Williams Mark A, Szczepura Ala, Ashby Deborah, Cooke Matthew W, Underwood Martin R, Gates Simon, Lamb Sarah E, Withers Emma J, Mt Isa Shahrul, Gumber Anil   +10 more
doaj   +1 more source

A cluster randomised control trial of a multi-component weight management programme for adults with intellectual disabilities and obesity [PDF]

, 2017
There have been few published controlled studies of multi-component weight management programmes that include an energy deficit diet (EDD), for adults with intellectual disabilities and obesity.
Boyle, Susan, Hankey, Catherine, Harris, Leanne, Jones, Nathalie, Melville, Craig, Murray, Heather, Pert, Carol, Tobin, Janet   +7 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

GestationaL Obesity Weight management: Implementation of National Guidelines (GLOWING): a pilot cluster randomised controlled trial of a guideline implementation intervention for the management of maternal obesity by midwives

Pilot and Feasibility Studies, 2018
Background Weight management in pregnancy guidelines exist, although dissemination alone is an ineffective means of implementation. Midwives identify the need for support to overcome complex barriers to practice.
Nicola Heslehurst, Judith Rankin, Catherine McParlin, Falko F. Sniehotta, Denise Howel, Stephen Rice, Elaine McColl   +6 more
doaj   +1 more source

Embedded motivational interviewing combined with a smartphone app to increase physical activity in people with sub-acute low back pain: study protocol of a cluster randomised control trial [PDF]

, 2019
Background: Motivational Interviewing is an evidence-based, client-centred counselling technique that has been used effectively to increase physical activity, including for people with low back pain.
Breckon, Jeff, Davidson, M, Holden, J, Monfries, M, O’ Halloran, PD, Rahayu, W, Taylor, NF   +6 more
core   +2 more sources

Missing Data in Cluster Randomised Trials [PDF]

, 2017
Missing outcomes are a commonly occurring problem in cluster randomised trials, which can lead to biased and inefficient inference if ignored or handled inappropriately. Handling missing data in CRTs is complicated due to the hierarchical structure of the data. Two approaches for analysing such trials are cluster-level analysis and individual level
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Sexually transmitted infection as a risk factor for homosexual HIV transmission: a systematic review of epidemiological studies

, 2000
Existing reviews suggest some sexually transmitted infections (STIs) are risk factors in heterosexual HIV transmission. This may not be so in homosexual HIV transmission, about which reviews make no specific conclusions.
Bonell, C, Hickson, F, Weatherburn, P
core   +1 more source

Protocol for the effective feedback to improve primary care prescribing safety (EFIPPS) study : a cluster randomised controlled trial using ePrescribing data [PDF]

, 2012
High-risk prescribing in primary care is common and causes considerable harm. Feedback interventions to improve care are attractive because they are relatively cheap to widely implement. There is good evidence that feedback has small to moderate effects,
Barnett, Karen, Bennie, Marion, Guthrie, Bruce, Petrie, Dennis, Ritchie, Lewis, Robertson, Chris, Treweek, S.   +6 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source