Results 121 to 130 of about 177,882 (303)

Promoting Recruitment using Information Management Efficiently (PRIME): a stepped-wedge, cluster randomised trial of a complex recruitment intervention embedded within the REstart or Stop Antithrombotics Randomised Trial

Trials, 2017
Background Few interventions are proven to increase recruitment in clinical trials. Recruitment to RESTART, a randomised controlled trial of secondary prevention after stroke due to intracerebral haemorrhage, has been slower than expected.
Amy E. Maxwell, Richard A. Parker, Jonathan Drever, Anthony Rudd, Martin S. Dennis, Christopher J. Weir, Rustam Al-Shahi Salman   +6 more
doaj   +1 more source

The art of HIV elimination: past and present science [PDF]

, 2015
Introduction: Remarkable strides have been made in controlling the HIV epidemic, although not enough to achieve epidemic control. More recently, interest in biomedical HIV control approaches has increased, but substantial challenges with the HIV cascade ...
de Oliveira, T., Fisher, M., Lwuji, C.C., McGrath, N., Newell, M.-L., Newport, M., Pillay, D., Porter, K.   +7 more
core   +1 more source

Spatial Analysis of Cluster Randomised Trials [PDF]

, 2018
Cluster randomised trials (CRTs) often use geographical areas as the unit of randomisation. Despite this, explicit consideration of the location and spatial distribution of observations is rare. In many trials, the location of participants will have little importance, however in some, especially against infectious diseases, spillover effects due to ...
openaire   +1 more source

Cluster randomisation trials in mental health research [PDF]

Evidence Based Mental Health, 2000
The unit of allocation in most clinical trials is the individual patient. However, experimental trials in which the unit of allocation is an intact cluster of participants (eg, families, schools, medical practices, communities) are becoming increasingly widespread in the evaluation of healthcare and educational interventions.
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Implementing telephone triage in general practice: a process evaluation of a cluster randomised controlled trial [PDF]

, 2015
Background: Telephone triage represents one strategy to manage demand for face-to-face GP appointments in primary care. However, limited evidence exists of the challenges GP practices face in implementing telephone triage.
A Fretheim, Anna Varley, B McKinstry, B McKinstry, C Pope, C Pope, Chris Salisbury, Colin Green, CR May, D Richards, DA Richards, David A Richards, Emily Fletcher, H Boon, I Holmstrom, J Green, J Murdoch, Jamie Murdoch, John L Campbell, Linnie Price, LS Meredith, M Jiwa, NB Baskerville, NC Campbell, Nicky Britten, P Craig, P Hawe, Raff Calitri, Rod S Taylor, RP Hermens, S Flottorp, SR Poole, Suzanne H Richards, V Lattimer, Valerie Lattimer   +34 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study)

Trials, 2011
Background The purpose of this research is to develop and evaluate methods for conducting cluster randomised trials in a primary care database that contains electronic patient records for large numbers of family practices.
Charlton Judith, Ashworth Mark, McCann Gerard, Dregan Alex, McDermott Lisa, van Staa Tjeerd, Gulliford Martin C, Grieve Andrew P, Little Paul, Moore Michael V, Yardley Lucy   +10 more
doaj   +1 more source

Evaluation of the impact of a school gardening intervention on children's fruit and vegetable intake: a randomised controlled trial. [PDF]

, 2014
Background: Current academic literature suggests that school gardening programmes can provide an interactive environment with the potential to change children’s fruit and vegetable intake.
A Hackett, A Harding, A Magarey, A Timperio, AJ Vickers, AM Craigie, AR Ness, C Devine, C Knai, Camilla Nykjaer, CE Evans, CE Evans, Charlotte EL Evans, E Van Cauwenberghe, EJ Ozer, J Connolly, J Morris, J Rasbash, JA O’Dea, Janet E Cade, JD McAleese, JE Cade, JN Davis, K Block, L Lautenschlager, L Lautenschlager, LA Bazzano, M Christian, M Maynard, M Nelson, MC Wang, Meaghan S Christian, MM Ratcliffe, MS Christian, MS Kitchen, MSEC Christian, Neil Hancock, P Boffetta, PJ Morgan, R Passy, R Robinson-O’Brien, S Koch, S Lineberger, S O’Brien, S Poston, S Somerset, S Somerset, SM Parmer, T Baranowski   +48 more
core   +2 more sources

Cluster randomised trials [PDF]

BMJ, 1999
N. Freemantle, J. Wood, M. K Campbell, J. M Grimshaw   +3 more
openaire   +1 more source