Results 131 to 140 of about 175,554 (303)

Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study)

Trials, 2011
Background The purpose of this research is to develop and evaluate methods for conducting cluster randomised trials in a primary care database that contains electronic patient records for large numbers of family practices.
Charlton Judith, Ashworth Mark, McCann Gerard, Dregan Alex, McDermott Lisa, van Staa Tjeerd, Gulliford Martin C, Grieve Andrew P, Little Paul, Moore Michael V, Yardley Lucy   +10 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Theories of behaviour change synthesised into a set of theoretical groupings: Introducing a thematic series on the Theoretical Domains Framework [PDF]

, 2012
Behaviour change is key to increasing the uptake of evidence into healthcare practice. Designing behaviour-change interventions first requires problem analysis, ideally informed by theory.
A McCluskey, AL Kitson, B Weiner, BH Cuthbertson, C Helms, Denise O’Connor, DQ Zhu, EM Rogers, G Godin, G Judah, G Stevens, J Cane, J Dyson, J Nzinga, Janet Curran, JE Clarkson, JE McKenzie, JE McKenzie, Jill J Francis, JJ Francis, JML Brotherton, L Guillaumie, LJ Damschroder, M Amemori, N Jacobs, NM Ivers, P Craig, P Edwards, R Foy, R Karasek, S Hetrick, S Michie, S Michie, S Michie, SU Dombrowski, VJ Pitt   +35 more
core   +3 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Cluster Randomised Trials

Journal of the Royal Statistical Society Series A: Statistics in Society, 2009
Richard J. Hayes, Lawrence H. Moulton
openaire   +2 more sources

Reconciling research and implementation in micro health insurance experiments in India: study protocol for a randomized controlled trial

Trials, 2011
Background Microinsurance or Community-Based Health Insurance is a promising healthcare financing mechanism, which is increasingly applied to aid rural poor persons in low-income countries.
Doyle Conor, Panda Pradeep, Van de Poel Ellen, Radermacher Ralf, Dror David M   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Randomised and non-randomised studies to estimate the effect of community-level public health interventions: definitions and methodological considerations

Emerging Themes in Epidemiology, 2017
Background The preferred method to evaluate public health interventions delivered at the level of whole communities is the cluster randomised trial (CRT).
Wolf-Peter Schmidt
doaj   +1 more source

CONSORT statement: extension to cluster randomised trials [PDF]

BMJ, 2004
Campbell, M, Elbourne, DR, Altman, D
openaire   +4 more sources