Results 61 to 70 of about 177,882 (303)

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Pragmatic pilot cluster randomised control trial of a school-based peer-led anti-smoking intervention for 13-14 year olds in Malaysia [PDF]

, 2017
Purpose The purpose of this paper is to report the process evaluation of a pilot randomised control trial of an anti-smoking intervention for Malaysian 13-14-year olds, conducted in 2011/2012.
Christopher Bridle, Elniee Melson, IPPF/WHR, Ministry of Education, Malaysia, Ministry of Health, Malaysia, Ministry of Health, Malaysia, Peace Corps, PROSTAR, Wolfgang Markham, YPEER   +9 more
core   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A scoping review of the problems and solutions associated with contamination in trials of complex interventions in mental health

BMC Medical Research Methodology, 2019
Background In a randomised controlled trial, contamination is defined as the receipt of active intervention amongst participants in the control arm.
Nicholas Magill, Ruth Knight, Paul McCrone, Khalida Ismail, Sabine Landau   +4 more
doaj   +1 more source

Sample size calculations for cluster randomised controlled trials with a fixed number of clusters [PDF]

, 2011
Background\ud Cluster randomised controlled trials (CRCTs) are frequently used in health service evaluation. Assuming an average cluster size, required sample sizes are readily computed for both binary and continuous outcomes, by estimating a design ...
A Donner, A Donner, A Pourshams, AJ Avery, Alan J Girling, Alice J Sitch, C Brown, C MacArthur, C MacArthur, DM Murray, Jennifer Marsh, Karla Hemming, L Guittet, MJ Davies, MK Campbell, MK Campbell, P Armitage, PL Yudkin, Richard J Lilford, RJ Lilford, SJ Edwards, SM Kerry, SM Kerry, Z Feng   +23 more
core   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Update to: Assessing the efficacy of male Wolbachia-infected mosquito deployments to reduce dengue incidence in Singapore

Trials
Background This trial is a parallel, two-arm, non-blinded cluster randomised controlled trial that is under way in Singapore, with the aim of measuring the efficacy of male Wolbachia-infected Aedes aegypti deployments in reducing dengue incidence in an ...
Jue Tao Lim, Diyar Mailepessov, Chee-Seng Chong, Chia-Chen Chang, Borame Dickens, Yee Ling Lai, Lu Deng, Caleb Lee, Li Yun Tan, Grace Chain, Soon Hoe Ho, Muhammad Faizal Zulkifli, Jonathan Liew, Kathryn Vasquez, Vernon Lee, Judith Chui Ching Wong, Shuzhen Sim, Cheong Huat Tan, Lee Ching Ng   +18 more
doaj   +1 more source

Undertaking a randomised controlled trial in the police setting : methodological and practical challenges [PDF]

, 2017
BACKGROUND: There has been an increased drive towards Evidence Based Policing in recent years. Unlike in other public sector services, such as health and education, randomised controlled trials in the police setting are relatively rare.
Booth, Alison, Fairhurst, Caroline, Hewitt, Catherine, McDaid, Catriona, Parker, Adwoa, Payne, Rebecca, Reed, Helen, Scantlebury, Arabella, Scott, William J, Torgerson, David   +9 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source