Results 71 to 80 of about 177,882 (303)

A simple and effective method for simulating nested exchangeable correlated binary data for longitudinal cluster randomised trials

BMC Medical Research Methodology
Background Simulation is an important tool for assessing the performance of statistical methods for the analysis of data and for the planning of studies.
Rhys A. Bowden, Jessica Kasza, Andrew B. Forbes   +2 more
doaj   +1 more source

The reimagination of school-based physical activity research in the COVID-19 era.

PLoS Medicine, 2020
Deirdre Harrington and Michelle O'Reilly discuss the article "Effectiveness and cost-effectiveness of the GoActive intervention to increase physical activity among UK adolescents: A cluster randomised controlled trial" by Kirsten Corder and colleagues.
Deirdre M Harrington, Michelle O'Reilly
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Impact of a theoretically based sex education programme (SHARE) delivered by teachers on NHS registered conceptions and terminations: final results of cluster randomised trial [PDF]

, 2006
<b>Objective</b>: To assess the impact of a theoretically based sex education programme (SHARE) delivered by teachers compared with conventional education in terms of conceptions and terminations registered by the NHS.
Abraham, C., Hart, G., Henderson, M., Parkes, A., Raab, G.M., Scott, S., Wight, D.   +6 more
core   +3 more sources

Demystifying estimands in cluster-randomised trials

Statistical Methods in Medical Research
Estimands can help clarify the interpretation of treatment effects and ensure that estimators are aligned with the study's objectives. Cluster-randomised trials require additional attributes to be defined within the estimand compared to individually randomised trials, including whether treatment effects are marginal or cluster-specific, and whether ...
Brennan C Kahan, Bryan S Blette, Michael O Harhay, Scott D Halpern, Vipul Jairath, Andrew Copas, Fan Li   +6 more
openaire   +4 more sources

[The CONSORT statement for cluster randomised trials].

Medicina clinica, 2011
With the publication of the CONSORT statement there is now increased awareness of the need to adequately report the findings of randomised controlled trials. The CONSORT statement includes a checklist of items that should be addressed in the trial report. The original CONSORT statement was developed to ensure the appropriate reporting of parallel group
Campbell, M, Elbourne, DR, Altman, D
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

School-based group interpersonal therapy for adolescents with depression in Nepal: protocol for a phase III realist cluster-randomised controlled trial

BMC Psychiatry
Background Depression is a leading cause of disability among adolescents, with the burden disproportionately affecting low- and middle-income countries (LMICs) where access to mental health care is limited.
Kelly Rose-Clarke, Cemile Ceren Sonmez, Sujan Shrestha, Bishnu Lamichhane, Indira Pradhan, Parbati Pandey, Pratima Kandel, John Hodsoll, Lauren Yan, Bryan Patenaude, Helen Verdeli, Kamal Gautam, Mark Jordans, Chris Bonell, Nagendra P. Luitel   +14 more
doaj   +1 more source

Insecticide-treated nets for the prevention of malaria in pregnancy: a systematic review of randomised controlled trials.

PLoS Medicine, 2007
BackgroundProtection from malaria with insecticide-treated bednets (ITNs) during pregnancy is widely advocated, but evidence of benefit has been inconsistent.
Carol Gamble, Paul J Ekwaru, Paul Garner, Feiko O ter Kuile   +3 more
doaj   +1 more source

Prehospital Randomised Assessment of a Mechanical Compression Device In Cardiac Arrest (PaRAMeDIC) Trial Protocol [PDF]

, 2010
BACKGROUND Survival after out-of-hospital cardiac arrest is closely linked to the quality of CPR, but in real life, resuscitation during prehospital care and ambulance transport is often suboptimal.
Anne Slowther, Charles Deakin, Chris McCabe, Gavin D Perkins, Jessica Horton, Malcolm Woollard, Matthew W Cooke, Ranjit Lall, Sarah E Lamb, Simon Gates, Tom Quinn   +10 more
core   +5 more sources