Results 1 to 10 of about 262,646 (192)

Balance algorithm for cluster randomized trials [PDF]

BMC Medical Research Methodology, 2008
Background Within cluster randomized trials no algorithms exist to generate a full enumeration of a block randomization, balancing for covariates across treatment arms.
Hood Kerenza, Carter Ben R
doaj   +11 more sources

Cluster Randomized Trials [PDF]

, 2019
This chapter discusses randomization, analysis, sample size and power for cluster randomized trials. Both continuous and binary outcomes are covered.
Crespi, Catherine, Crespi-Chun, Catherine   +1 more
core   +4 more sources

Randomization-Based Confidence Intervals for Cluster Randomized Trials [PDF]

Biostatistics, 2020
In a cluster randomized trial (CRT), groups of people are randomly assigned to different interventions. Existing parametric and semiparametric methods for CRTs rely on distributional assumptions or a large number of clusters to maintain nominal ...
Rabideau, Dustin J, Wang, Rui
core   +5 more sources

Guidelines for the content of statistical analysis plans in clinical trials: protocol for an extension to cluster randomized trials [PDF]

Trials
Background Guidance exists to inform the content of statistical analysis plans in clinical trials. Though not explicitly stated, this guidance is generally focused on clinical trials in which the randomization units are individual patients and not groups
Karla Hemming, Jacqueline Y. Thompson, Richard L. Hooper, Obioha C. Ukoumunne, Fan Li, Agnes Caille, Brennan C. Kahan, Clemence Leyrat, Michael J. Grayling, Nuredin I. Mohammed, Jennifer A. Thompson, Bruno Giraudeau, Elizabeth L. Turner, Samuel I. Watson, Beatriz Goulão, Jessica Kasza, Andrew B. Forbes, Andrew J. Copas, Monica Taljaard   +18 more
doaj   +2 more sources

Warnings on the inclusion of cluster randomized trials in meta-analysis: results of a simulation study [PDF]

BMC Medical Research Methodology
Background Consolidation of treatment effects from randomized controlled trials (RCT) is considered one of the highest forms of evidence in research.
Joseph Alvin Ramos Santos, Emilia Riggi, Gian Luca Di Tanna   +2 more
doaj   +2 more sources

Geographic pair matching in large-scale cluster randomized trials [PDF]

Nature Communications
Cluster randomized trials are often used to study large-scale public health interventions. In large trials, even small improvements in statistical efficiency can have profound impacts on the required sample size and cost.
Benjamin F. Arnold, Francois Rerolle, Christine Tedijanto, Sammy M. Njenga, Mahbubur Rahman, Ayse Ercumen, Andrew Mertens, Amy J. Pickering, Audrie Lin, Charles D. Arnold, Kishor Das, Christine P. Stewart, Clair Null, Stephen P. Luby, John M. Colford, Alan E. Hubbard, Jade Benjamin-Chung   +16 more
doaj   +2 more sources

Gaps in the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials: a citation analysis reveals a need for updated ethics guidelines [PDF]

Research Integrity and Peer Review
Background Although commonly used to evaluate health interventions, cluster randomized trials raise difficult ethical issues. Recognizing this, the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials, published in 2012 ...
Cory E. Goldstein, Jessica du Toit, Nicholas B. Murphy, Stuart G. Nicholls, Julia F. Shaw, Fernando Althabe, Ariella Binik, Jamie Brehaut, Sandra Eldridge, Rashida A. Ferrand, Katie Gillies, Bruno Giraudeau, Rieke van der Graaf, Lars G. Hemkens, Karla Hemming, Mira Johri, Scott Y. H. Kim, Emily Largent, Alex John London, Lawrence Mbuagbaw, Susan L. Mitchell, Maureen Smith, Peter Tugwell, Shaun Treweek, Vivian A. Welch, Monica Taljaard, Charles Weijer   +26 more
doaj   +2 more sources

Analysis methods for covariate-constrained cluster randomized trials with time-to-event outcomes [PDF]

BMC Medical Research Methodology
Background Cluster randomized trials, which often enroll a small number of clusters, can benefit from constrained randomization, selecting a final randomization scheme from a set of known, balanced randomizations.
Amy M. Crisp, M. Elizabeth Halloran, Matt D. T. Hitchings, Ira M. Longini, Natalie E. Dean   +4 more
doaj   +2 more sources

Performance of methods for analyzing continuous data from stratified cluster randomized trials – A simulation study

Contemporary Clinical Trials Communications, 2023
Background: The adoption of cluster randomized trials (CRTs) with the stratified design is currently gaining widespread interest. In the stratified design, clusters are first grouped into two or more strata and then randomized into treatment groups ...
Sayem Borhan, Jinhui Ma, Alexandra Papaioannou, Jonathan Adachi, Lehana Thabane   +4 more
doaj   +1 more source

A systematic review of the usage of flow diagram in cluster randomized trials [PDF]

Praxis Medica, 2014
Flow diagram represent an integral part of consolidated standards of reporting trials (CONSORT). Its use in reporting cluster randomization trials is highly recommended.
Kostić M., Ilić A., Bukumirić Z., Jovanović J., Trajković G.   +4 more
doaj   +1 more source