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Cluster randomized controlled trials
Journal of Evaluation in Clinical Practice, 2005AbstractCluster randomized controlled trial (RCT), in which groups or clusters of individuals rather than individuals themselves are randomized, are increasingly common. Indeed, for the evaluation of certain types of intervention (such as those used in health promotion and educational interventions) a cluster randomized trial is virtually the only ...
Suezann, Puffer +2 more
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2020
In some situations, it is preferable or necessary not to randomize individual patients but groups of patients, for example clinics, care homes, or households. These groups are commonly denoted as “clusters”. Two approaches for the analysis of cluster-randomized trials can be distinguished, and the chosen method has to be adequately incorporated in ...
Lawrence H. Moulton, Richard J. Hayes
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In some situations, it is preferable or necessary not to randomize individual patients but groups of patients, for example clinics, care homes, or households. These groups are commonly denoted as “clusters”. Two approaches for the analysis of cluster-randomized trials can be distinguished, and the chosen method has to be adequately incorporated in ...
Lawrence H. Moulton, Richard J. Hayes
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AAP Grand Rounds, 2011
Over the last century, the randomized clinical trial has become the gold standard for interventional studies. Typically individuals are randomly assigned to an experimental group or a control group. What if it was impractical or unethical to randomize individuals to a treatment group? This is where the cluster randomized trial design comes in.
Todd A. Florin, Samir S. Shah
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Over the last century, the randomized clinical trial has become the gold standard for interventional studies. Typically individuals are randomly assigned to an experimental group or a control group. What if it was impractical or unethical to randomize individuals to a treatment group? This is where the cluster randomized trial design comes in.
Todd A. Florin, Samir S. Shah
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Balance in cluster randomized trials
Statistics in Medicine, 2001This paper explores the role of balancing covariates between treatment groups in the design of cluster randomized trials. General expressions are obtained for two criteria to evaluate designs for parallel group studies with two treatments. The first is the variance of the estimated treatment effect and the second is the extent to which the estimated ...
G M, Raab, I, Butcher
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Randomization inference for balanced cluster-randomized trials
Clinical Trials, 2005This paper discusses the choice of randomization tests for inferences from cluster-randomized trials that have been designed to ensure a balanced allocation of clusters to treatments. Methods for covariate-adjusted randomization tests are reviewed and their application to balanced cluster-randomized trials discussed. Two cluster-randomized trials with
Gillian M, Raab, Isabella, Butcher
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The Cluster Randomized Trial Study Design
AJN, American Journal of Nursing, 2023Editor's note: This is the 17th article in a series on clinical research by nurses. The series is designed to be used as a resource for nurses to understand the concepts and principles essential to research. Each column will present the concepts that underpin evidence-based practice—from research design to data interpretation.
Bernadette, Capili, Joyce K, Anastasi
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Intra‐cluster correlation selection for cluster randomized trials
Statistics in Medicine, 2016In this paper, we give focus to cluster randomized trials, also known as group randomized trials, which randomize clusters, or groups, of subjects to different trial arms, such as intervention or control. Outcomes from subjects within the same cluster tend to exhibit an exchangeable correlation measured by the intra‐cluster correlation coefficient (ICC)
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Cluster Randomization Trials: A Simulation Study
Biometrical Journal, 2002zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Song, James X., Ahn, Chul
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Cluster randomized trials for HIV prevention
Current Opinion in HIV and AIDS, 2006This paper reviews cluster randomized trials for HIV prevention, focusing on the unique aspects of such trials and describes key cluster randomized trials for HIV prevention from the past decade. Relevant methodological issues are also reviewed.Three cluster randomized trials evaluating sexually transmitted infection control as an HIV prevention tool ...
James P, Hughes, Michal, Kulich
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