Results 11 to 20 of about 262,646 (192)

Analysis of multiple-period group randomized trials: random coefficients model or repeated measures ANOVA?

Trials, 2022
Background Multiple-period parallel group randomized trials (GRTs) analyzed with linear mixed models can represent time in mean models as continuous or categorical.
Jonathan C. Moyer, Patrick J. Heagerty, David M. Murray   +2 more
doaj   +1 more source

Comparing analytical strategies for balancing site-level characteristics in stepped-wedge cluster randomized trials: a simulation study

BMC Medical Research Methodology, 2023
Background Stepped-wedge cluster randomized trials (SWCRTs) are a type of cluster-randomized trial in which clusters are randomized to cross-over to the active intervention sequentially at regular intervals during the study period. For SWCRTs, sequential
Clement Ma, Alina Lee, Darren Courtney, David Castle, Wei Wang   +4 more
doaj   +1 more source

Cluster identification, selection, and description in cluster randomized crossover trials: the PREP-IT trials

Trials, 2020
Background In cluster randomized crossover (CRXO) trials, groups of participants (i.e., clusters) are randomly allocated to receive a sequence of interventions over time (i.e., cluster periods).
Sheila Sprague, Taryn Scott, Shannon Dodds, David Pogorzelski, Paula McKay, Anthony D. Harris, Amber Wood, Lehana Thabane, Mohit Bhandari, Samir Mehta, Greg Gaski, Christina Boulton, Francesc Marcano-Fernández, Ernesto Guerra-Farfán, Joan Hebden, Lyndsay M. O’Hara, Gerard P. Slobogean, on behalf of the PREP-IT Investigators   +17 more
doaj   +1 more source

Estimation of Conditional Power for Cluster-Randomized Trials with Interval-Censored Endpoints [PDF]

, 2020
Cluster-randomized trials (CRTs) of infectious disease preventions often yield correlated, interval-censored data: dependencies may exist between observations from the same cluster, and event occurrence may be assessed only at intermittent clinic visits.
Hayes R.J., Komárek A., Lan K.K.G., Proschan M.A., Turnbull B.W.   +4 more
core   +3 more sources

Evaluating performance of covariate-constrained randomization (CCR) techniques under misspecification of cluster-level variables in cluster-randomized trials

Contemporary Clinical Trials Communications, 2021
Covariate constrained randomization (CCR) is a method of controlling imbalance in important baseline covariates in cluster-randomized trials (CRT). We use simulated CRTs to investigate the performance (control of imbalance) of CCR relative to simple ...
Madeleine Organ, S. Darius Tandon, Alicia Diebold, Jessica K. Johnson, Chen Yeh, Jody D. Ciolino   +5 more
doaj   +1 more source

Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials

Trials, 2020
An amendment to this paper has been published and can be accessed via the original article.
Sheila Sprague, Taryn Scott, Shannon Dodds, David Pogorzelski, Paula McKay, Anthony D. Harris, Amber Wood, Lehana Thabane, Mohit Bhandari, Samir Mehta, Greg Gaski, Christina Boulton, Francesc Marcano-Fernández, Ernesto Guerra-Farfán, Joan Hebden, Lyndsay M. O’Hara, Gerard P. Slobogean, on behalf of the PREP-IT Investigators   +17 more
doaj   +1 more source

Participant informed consent in cluster randomized trials: review. [PDF]

PLoS ONE, 2012
BackgroundThe Nuremberg code defines the general ethical framework of medical research with participant consent as its cornerstone. In cluster randomized trials (CRT), obtaining participant informed consent raises logistic and methodologic concerns ...
Bruno Giraudeau, Agnès Caille, Amélie Le Gouge, Philippe Ravaud   +3 more
doaj   +1 more source

Design of trials for interrupting the transmission of endemic pathogens [PDF]

, 2016
Many interventions against infectious diseases have geographically diffuse effects. This leads to contamination between arms in cluster-randomized trials (CRTs).
Hiscox, Alexandra, Homan, Tobias, Maire, Nicolas, Mukabana, Richard, Silkey, Mariabeth, Smith, Thomas A., Takken, Willem   +6 more
core   +3 more sources

Matching in cluster randomized trials using the Goldilocks Approach

Contemporary Clinical Trials Communications, 2021
In group or cluster-randomized trials (GRTs), matching is a technique that can be used to improve covariate balance. When baseline data are available, we suggest a strategy that can be used to achieve the desired balance between treatment and control ...
S. Gwynn Sturdevant, Susan S. Huang, Richard Platt, Ken Kleinman   +3 more
doaj   +1 more source

Leveraging Contact Network Structure in the Design of Cluster Randomized Trials [PDF]

, 2016
Background: In settings like the Ebola epidemic, where proof-of-principle trials have succeeded but questions remain about the effectiveness of different possible modes of implementation, it may be useful to develop trials that not only generate ...
DeGruttola, Victor, Harling, Guy, Onnela, Jukka-Pekka, Wang, Rui   +3 more
core   +3 more sources