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整群随机试验 Cluster Randomized Trials
Zhongguo cuzhong zazhi, 2022 整群随机试验在临床研究中应用较为广泛，其以“群”为随机单位，一个群中的所有个体接受相同的干预，因此与以个体为随机单位的随机对照试验相比，整群随机试验能够减少“沾染”，组织实施更为简便，更适合公共卫生措施评价和医疗质量改进研究。然而，整群随机试验组间可比性欠佳，存在设计效应，因此需要较大的样本量。本文将从整群随机试验的历史渊源、基本概念、研究设计、应用场景和案例解读、报告规范等方面进行全面总结，以期帮助临床研究者认识、了解、掌握此类研究设计。 Abstract: Cluster randomized
朱之恺1 ，谷鸿秋1，2，姜勇1
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Methods for the analysis of incidence rates in cluster randomized trials. [PDF]
, 2002 BACKGROUND: The published literature on cluster randomized trials focuses on outcomes that are either continuous or binary. In many trials, the outcome is an incidence rate, such as mortality, based on person-years data.
Bennett, Steve +3 more
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Cluster Randomized Controlled Trials (CRCTs) in Evidence-Based Dentistry
Dental Hypotheses, 2012 A cluster randomized controlled trial (CRCT) is a type of randomized controlled trial in which groups of subjects (as opposed to individual subjects) are randomized.
Francesco Chiappelli
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Ethics of alternative trial designs and methods in low-resource settings
Trials, 2019 This editorial introduces articles in this Special Issue, which are based on presentations given at the 2017 meeting of the Global Forum of Bioethics in Research meeting. The main themes presented at the meeting were the use of cluster randomized trials,
Rieke van der Graaf, Phaik Yeong Cheah
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Trials, 2020 Background Cluster randomized trials (CRTs) are a design used to test interventions where individual randomization is not appropriate. The mixed model for repeated measures (MMRM) is a popular choice for individually randomized trials with longitudinal ...
Melanie L. Bell, Brooke A. Rabe
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Empirical power and sample size calculations for cluster-randomized and cluster-randomized crossover studies. [PDF]
PLoS ONE, 2012 In recent years, the number of studies using a cluster-randomized design has grown dramatically. In addition, the cluster-randomized crossover design has been touted as a methodological advance that can increase efficiency of cluster-randomized studies ...
Nicholas G Reich +4 more
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Sample Size Considerations in the Design of Cluster Randomized Trials of Combination HIV Prevention [PDF]
, 2013 BACKGROUND: Cluster randomized trials have been utilized to evaluate the effectiveness of human immunodeficiency virus (HIV) prevention strategies on reducing incidence.
DeGruttola, Victor +4 more
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Trials, 2020 Background Cluster randomized trials are common in health research in low- and middle-income countries raising issues that challenge interpretation of standard ethical guidelines.
Augustine T. Choko +7 more
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Erratum to: Handling Missing Data in Within-Trial Cost-Effectiveness Analysis: A Review with Future Recommendations. [PDF]
, 2017 Reference 5, which reads: 5. Manca P, Palmer S. Handling missing values in cost effectiveness analyses that use data from cluster randomized trials. Appl Health Econ Health Policy. 2006;4:65–75. Should read: 5. Manca A, Palmer S. Handling missing data in
Baio, Gianluca +2 more
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Allocation techniques for balance at baseline in cluster randomized trials: a methodological review
Trials, 2012 Reviews have repeatedly noted important methodological issues in the conduct and reporting of cluster randomized controlled trials (C-RCTs). These reviews usually focus on whether the intracluster correlation was explicitly considered in the design and ...
Ivers Noah M +7 more
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