Results 41 to 50 of about 262,646 (192)
Alternative clinical trial designs
Trauma Surgery & Acute Care Open, 2020 High-quality clinical trials are needed to advance the care of injured patients. Traditional randomized clinical trials in trauma have challenges in generating new knowledge due to many issues, including logistical difficulties performing individual ...
John A Harvin +4 more
doaj +1 more source
New players in the preventive treatment of migraine. [PDF]
, 2015 Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed ...
Mitsikostas, Dimos D, Rapoport, Alan M
core +3 more sources
Trials, 2009 Background Cluster randomized trials are an increasingly important methodological tool in health research. In cluster randomized trials, intact social units or groups of individuals, such as medical practices, schools, or entire communities – rather than
Chaudhry Shazia H +12 more
doaj +1 more source
Methods for dealing with unequal cluster sizes in cluster randomized trials: A scoping review.
PLoS ONE, 2021 In a cluster-randomized trial (CRT), the number of participants enrolled often varies across clusters. This variation should be considered during both trial design and data analysis to ensure statistical performance goals are achieved.
Denghuang Zhan +4 more
doaj +1 more source
, 2013 The primary goal of randomized trials is to compare the effects of different interventions on some outcome of interest. In addition to the treatment assignment and outcome, data on baseline covariates, such as demographic characteristics or biomarker ...
De Gruttola, Victor +2 more
core +1 more source
More Powerful Cluster Randomized Control Trials
Economic Development and Cultural Change, 2022 Balanced experimental designs, in which the number of treatment and control units are the same, do not maximize power subject to a cost constraint when treat-ment units are more expensive than control ones. Despite this, such balanced designs are the norm in economics. This paper describes methods to optimally choose the number of treatment and control
Marcos Vera-Hernandez, Brendon McConnell
openaire +3 more sources
Short- and long-term effects of a multi-component physical activity intervention in primary school [PDF]
, 2012 There is compelling evidence that physical activity has numerous health benefits during childhood and adolescence. Insufficient levels of physical activity on the other hand can consequently affect cardiovascular and bone health, which may result in ...
Meyer, Ursina
core +1 more source
Randomization techniques in protocols for cluster randomized trials [PDF]
Praxis Medica, 2017 Planning cluster randomized studies requires special attention due to their specific design. To achieve balance on a cluster level as well as on individual level, it is necessary to apply randomization techniques which involve restricted randomization ...
Kostić Mirjana +5 more
doaj
Effectiveness of social marketing strategies to reduce youth obesity in European school-based interventions : a systematic review and meta-analysis [PDF]
, 2016 Peer reviewedPublisher ...
Aceves Martins, Magaly +6 more
core +5 more sources
Analysis of contamination in cluster randomized trials of malaria interventions
Trials, 2021 Background In cluster randomized trials (CRTs) of interventions against malaria, mosquito movement between households ultimately leads to contamination between intervention and control arms, unless they are separated by wide buffer zones.
Lea Multerer +3 more
doaj +1 more source