Results 71 to 80 of about 262,646 (192)

Ethical issues posed by cluster randomized trials in health research

Trials, 2011
The cluster randomized trial (CRT) is used increasingly in knowledge translation research, quality improvement research, community based intervention studies, public health research, and research in developing countries.
Donner Allan, Brehaut Jamie C, Boruch Robert, Binik Ariella, Taljaard Monica, Grimshaw Jeremy M, Weijer Charles, Eccles Martin P, Gallo Antonio, McRae Andrew D, Saginur Raphael, Zwarenstein Merrick   +11 more
doaj   +1 more source

Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression

, 2013
Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS).
Friede, Tim, Nicholas, Richard, Röver, Christian, Schneider, Simon, Steinvorth, Simon M., Straube, Sebastian   +5 more
core   +1 more source

Imputation strategies for missing binary outcomes in cluster randomized trials

BMC Medical Research Methodology, 2011
Background Attrition, which leads to missing data, is a common problem in cluster randomized trials (CRTs), where groups of patients rather than individuals are randomized.
Akhtar-Danesh Noori, Ma Jinhui, Dolovich Lisa, Thabane Lehana   +3 more
doaj   +1 more source

Reliability, Effect Size, and Responsiveness and Intraclass Correlation of Health Status Measures Used in Randomized and Cluster-Randomized Trials [PDF]

, 2006
Background: New health status instruments are described by psychometric properties, such as Reliability, Effect Size, and Responsiveness. For cluster-randomized trials, another important statistic is the Intraclass Correlation for the instrument within ...
Chen, Lu, Diehr, Paula, Feng, Ziding, Patrick, Donald L., Yasui, Yutaka   +4 more
core   +1 more source

Cluster-randomized, crossover trial of head positioning in acute stroke [PDF]

, 2013
The role of supine positioning after acute stroke in improving cerebral blood flow and the countervailing risk of aspiration pneumonia have led to variation in head positioning in clinical practice.
Anderson, Craig, Arima, Hisatomi, Lavados, Pablo, Billot, Laurent, Hackett, Maree, Olavarria, Veronica, Munoz-Venturelli, Paula, Brunser, Alejandro, Peng, Bin, Cui, Liying, Song, Lily, Rogers, Kerrylee, Middleton, Sandy, Lim, Joyce Y., Forshaw, Denise, Lighbody, C. Elizabeth, Woodward, Mark, Pontes-Neto, Octavio, de Silva, H. Asita, Ruey-Tay, Lin, Lee, Tay H., Pandian, Jeyaraj, Mead, Gillian, Robinson, Thompson, Watkins, Caroline Leigh   +24 more
core   +5 more sources

Feasibility of a cluster-randomized influenza vaccination trial in U.S. nursing homes: Lessons learned

Human Vaccines & Immunotherapeutics, 2018
Influenza severity increases and vaccine effectiveness decreases with age. High-dose influenza vaccine (HD) with quadruple the antigen of standard-dose (SD) vaccine is more efficacious in community-dwelling persons 65 years and older.
Stefan Gravenstein, H. Edward Davidson, Lisa F. Han, Jessica A. Ogarek, Roshani Dahal, Pedro L. Gozalo, Monica Taljaard, Vincent Mor   +7 more
doaj   +1 more source

Cluster‐randomized controlled trials: A tutorial

Cochrane Evidence Synthesis and Methods, 2023
Marty Chaplin, Kerry Dwan
doaj   +1 more source

Methods for analyzing cost effectiveness data from cluster randomized trials

Cost Effectiveness and Resource Allocation, 2007
Background Measurement of individuals' costs and outcomes in randomized trials allows uncertainty about cost effectiveness to be quantified. Uncertainty is expressed as probabilities that an intervention is cost effective, and confidence intervals of ...
Clark Allan, Fairall Lara, Bachmann Max O, Mugford Miranda   +3 more
doaj   +1 more source

Experimental designs for multiple-level responses, with application to a large-scale educational intervention

, 2009
Educational research often studies subjects that are in naturally clustered groups of classrooms or schools. When designing a randomized experiment to evaluate an intervention directed at teachers, but with effects on teachers and their students, the ...
Jenney, Brenda, Lohr, Sharon
core   +1 more source

Improved Designs for Cluster Randomized Trials [PDF]

Annual Review of Public Health, 2016
Studies in which clusters of individuals are randomized to conditions are increasingly common in public health research. However, the designs utilized for such studies are often suboptimal and inefficient. We review strategies to improve the design of cluster randomized trials. We discuss both older but effective design concepts that are underutilized,
openaire   +2 more sources