Results 1 to 10 of about 144,547 (25)
Lethal DNA damages caused by ion-induced shock waves in cells [PDF]
Phys. Rev. E 104 (2021) 054408, 2021 The elucidation of fundamental mechanisms underlying ion-induced radiation damage of biological systems is crucial for the advancement of radiotherapy with ion beams and for radiation protection in space. The study of ion-induced biodamage using the phenomenon-based MultiScale Approach to the physics of radiation damage with ions (MSA) has led to the ...
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Molecular rectifiers with very high rectification ratio enabled by oxidative damage in double-stranded DNA [PDF]
J. Phys. Chem. B 2022, 126, 25, 4636-4646, 2022 In this work, we report a novel strategy to construct molecular diodes with a record tunable rectification ratio of as high as 10^6 using oxidatively damaged DNA molecules. Being exposed to several endogenous and exogenous events, DNA suffers constant oxidative damages leading to oxidation of guanine to 8-Oxoguanine (8oxoG).
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Calculation of complex DNA damage induced by ions [PDF]
Physical Review E 84, 051918 (2011), 2011 This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The analysis and assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be sufficiently effective.
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Electronic Excitation Response of DNA to High-energy Proton Radiation in Water [PDF]
Physical Review Letters 130, 118401 (2023), 2023 The lack of molecular-level understanding for the electronic excitation response of DNA to charged particle radiation, such as high-energy protons, remains a fundamental scientific bottleneck in advancing proton and other ion beam cancer therapies.
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Reactive Molecular Dynamics study on the first steps of DNA-damage by free hydroxyl radicals [PDF]
J. Phys. Chem. A 115, 11045 (2011), 2011 We employ a large scale molecular simulation based on bond-order ReaxFF to simulate the chemical reaction and study the damage to a large fragment of DNA-molecule in the solution by ionizing radiation. We illustrate that the randomly distributed clusters of diatomic OH-radicals that are primary products of megavoltage ionizing radiation in water-based ...
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A molecular dynamics simulation of DNA damage induction by ionizing radiation [PDF]
Phys. Med. Biol. 58 (2013) 7143-7157, 2013 We present a multi-scale simulation of early stage of DNA damages by the indirect action of hydroxyl ($^\bullet$OH) free radicals generated by electrons and protons. The computational method comprises of interfacing the Geant4-DNA Monte Carlo with the ReaxFF molecular dynamics software.
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Track structure simulation of low energy electron damage to DNA using Geant4-DNA [PDF]
Biomedical Physics & Engineering Express 4 (2018) 065009, 2018 Due to the physical and chemical processes that are involved, interactions of ionizing radiations with cells lead to single- and double-strand breaks (SSB and DSB) and base damage to DNA cells. The damage may kill the cells or may be mis-repaired and lead to genetic diseases and cancers. Track structure Monte Carlo simulation of the DNA damage provides
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Tau affects P53 function and cell fate during the DNA damage response [PDF]
Communications Biology 3, 245 (2020), 2020 Cells are constantly exposed to DNA damaging insults. To protect the organism, cells developed a complex molecular response coordinated by P53, the master regulator of DNA repair, cell division and cell fate. DNA damage accumulation and abnormal cell fate decision may represent a pathomechanism shared by aging-associated disorders such as cancer and ...
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Multiscale approach to radiation damage induced by ion beams: complex DNA damage and effects of thermal spikes [PDF]
, 2010 We present the latest advances of the multiscale approach to radiation damage caused by irradiation of a tissue with energetic ions and report the most recent advances in the calculations of complex DNA damage and the effects of thermal spikes on biomolecules.
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A new intermolecular mechanism to selectively drive photoinduced damages [PDF]
Nature, 505, 661 (2014), 2013 Low-energy electrons (LEEs) are known to be effective in causing strand breaks in DNA. Recent experiments show that an important direct source of LEEs is the intermolecular Coulombic decay (ICD) process. Here we propose a new cascade mechanism initiated by core excitation and terminated by ICD and demonstrate its properties.
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