Clustered DNA Damage Patterns after Proton Therapy Beam Irradiation Using Plasmid DNA [PDF]
International Journal of Molecular Sciences, 2022 Modeling ionizing radiation interaction with biological matter is a major scientific challenge, especially for protons that are nowadays widely used in cancer treatment. That presupposes a sound understanding of the mechanisms that take place from the early events of the induction of DNA damage. Herein, we present results of irradiation-induced complex
Maria P. Souli +9 more
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Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines [PDF]
Translational Oncology, 2022 The bone-seeking radiopharmaceutical Xofigo (Radium-223 dichloride) has demonstrated both extended survival and palliative effects in treatment of bone metastases in prostate cancer.
Andris Abramenkovs +4 more
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The 2Ih and OXOG Proximity Consequences on Charge Transfer through ds-DNA: Theoretical Studies of Clustered DNA Damage [PDF]
Molecules, 2023 Genetic information is continuously exposed to harmful factors, both intra- and extracellular. Their activity can lead to the formation of different types of DNA damage. Clustered lesions (CDL) are problematic for DNA repair systems.
Boleslaw T. Karwowski
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How Clustered DNA Damage Can Change the Electronic Properties of ds-DNA—Differences between GAG, GAOXOG, and OXOGAOXOG [PDF]
Biomolecules, 2023 Every 24 h, roughly 3 × 1017 incidences of DNA damage are generated in the human body as a result of intra- or extra-cellular factors. The structure of the formed lesions is identical to that formed during radio- or chemotherapy.
Boleslaw Karwowski
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Order effect of repair processes to clustered DNA damage [PDF]
Journal of Radiation Research, 2014 In a living cell, a multiply damaged site in DNA is thought to be processed by several different pathways simultaneously or sequentially. Under this situation, the cellular response to the lesion cluster might depend on the order of repair processes because the configuration of the lesions will be modified by the reaction of initial repair protein ...
Shiraishi, Iyo +4 more
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The role of DNA polymerase I in tolerating single-strand breaks generated at clustered DNA damage in Escherichia coli [PDF]
Scientific ReportsClustered DNA damage, when multiple lesions are generated in close proximity, has various biological consequences, including cell death, chromosome aberrations, and mutations. It is generally perceived as a hallmark of ionizing radiation.
Naoya Shikazono, Ken Akamatsu
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Chemical Aspects of Clustered DNA Damage Induction by Ionising Radiation
Radiation Protection Dosimetry, 2002 Ionising radiation induces a variety of chemical modifications to DNA, ranging from simple, isolated lesions to clustered DNA damage, in which two or more lesions are formed within a few tens of base pairs by a single radiation track. Multiple lesions, e.g. tandem lesions and amplification of damage, may also be induced in DNA by reaction with a single
Lomax, M, Gulston, M, O'Neill, P
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Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK [PDF]
Nucleic Acids Research, 2013 DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2AX is a key step in facilitating efficient DSB repair ...
Meyer, Barbara +5 more
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Multinomial probability model of radiation induced DSB and non-DSB clusters: tandem and bistranded damage clusters [PDF]
Scientific ReportsExperiments have shown that non-double strand break (DSB) clustered damage consisting of two or more base damages (BDs) or BD with single strand breaks (SSBs) occur with higher frequency than DSBs after ionizing radiation exposure.
Francis A. Cucinotta
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Delayed repair of radiation induced clustered DNA damage: Friend or foe?
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2011 A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand breaks (DSB) with associated base lesions or abasic (AP) sites, and non-DSB clusters comprised of base ...
Eccles, L, O'Neill, P, Lomax, M
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