Modeling Clustered DNA Damage by Ionizing Radiation Using Multinomial Damage Probabilities and Energy Imparted Spectra. [PDF]
Int J Mol SciSimple and complex clustered DNA damage represent the critical initial damage caused by radiation. In this paper, a multinomial probability model of clustered damage is developed with probabilities dependent on the energy imparted to DNA and surrounding water molecules.
Cucinotta FA.
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The role of DNA polymerase I in tolerating single-strand breaks generated at clustered DNA damage in Escherichia coli [PDF]
Scientific ReportsClustered DNA damage, when multiple lesions are generated in close proximity, has various biological consequences, including cell death, chromosome aberrations, and mutations. It is generally perceived as a hallmark of ionizing radiation.
Naoya Shikazono, Ken Akamatsu
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Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK. [PDF]
Nucleic Acids Res, 2013 DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2AX is a key step in facilitating efficient DSB repair ...
Meyer B +5 more
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Order effect of repair processes to clustered DNA damage [PDF]
J Radiat Res, 2014 In a living cell, a multiply damaged site in DNA is thought to be processed by several different pathways simultaneously or sequentially. Under this situation, the cellular response to the lesion cluster might depend on the order of repair processes because the configuration of the lesions will be modified by the reaction of initial repair protein ...
Shiraishi I +4 more
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Multinomial probability model of radiation induced DSB and non-DSB clusters: tandem and bistranded damage clusters [PDF]
Scientific ReportsExperiments have shown that non-double strand break (DSB) clustered damage consisting of two or more base damages (BDs) or BD with single strand breaks (SSBs) occur with higher frequency than DSBs after ionizing radiation exposure.
Francis A. Cucinotta
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Quantifying DNA strand breaks from targeted alpha emitters 225Ac and 227Th via Geant4-DNA: implications for RBE and cell survival [PDF]
EJNMMI PhysicsBackground Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like 225Ac and 227Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage.
Samaneh Zolghadri +2 more
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Base-excision repair increases DNA double-strand break clustering within heavy-ion tracks and modulates repair at δ-electron-induced breaks [PDF]
Scientific ReportsSpace radiation poses a threat to human health during space missions. Its biological effect largely depends on heavy ions. These induce highly clustered DNA damage along their tracks, which is difficult to repair. If this damage is not repaired correctly,
Laura Schwan +3 more
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Delayed repair of radiation induced clustered DNA damage: friend or foe?
Mutat Res, 2011 A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand breaks (DSB) with associated base lesions or abasic (AP) sites, and non-DSB clusters comprised of base ...
Eccles LJ, O'Neill P, Lomax ME.
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Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products [PDF]
Journal of Genetic Engineering and BiotechnologyIonizing radiation (IR) is a key cancer treatment, but its DNA-damaging effects, particularly double-strand breaks (DSBs) and clustered lesions, pose challenges for therapy.
Kouass Sahbani Saloua, Rayan M. Alansari
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Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy. [PDF]
Proc Natl Acad Sci U S A, 2022 Nakano T +8 more
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