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Multinomial probability model of radiation induced DSB and non-DSB clusters: tandem and bistranded damage clusters [PDF]
Scientific ReportsExperiments have shown that non-double strand break (DSB) clustered damage consisting of two or more base damages (BDs) or BD with single strand breaks (SSBs) occur with higher frequency than DSBs after ionizing radiation exposure.
Francis A. Cucinotta
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Chromatin and the Cellular Response to Particle Radiation-Induced Oxidative and Clustered DNA Damage
Frontiers in Cell and Developmental Biology, 2022 Exposure to environmental ionizing radiation is prevalent, with greatest lifetime doses typically from high Linear Energy Transfer (high-LET) alpha particles via the radioactive decay of radon gas in indoor air.
John M. Danforth +2 more
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The Effects of Particle LET and Fluence on the Complexity and Frequency of Clustered DNA Damage
DNAMotivation: Clustered DNA-lesions are predominantly induced by ionizing radiation, particularly by high-LET particles, and considered as lethal damage. Quantification of this specific type of damage as a function of radiation parameters such as LET, dose
Mohammad Rezaee, Amitava Adhikary
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Cells, 2020 Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron−sulfur glycosylases (MutyH), which can recognize them by the ...
Boleslaw T. Karwowski
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SensorsGuided wave array-based structural health monitoring (SHM) is a promising solution for diagnosing damage in metal-connected structures. In this field, the reconstruction algorithm for probabilistic inspection (RAPID) is one of the most widely used ...
Qiao Bao +3 more
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Frontiers in Physics, 2021 Existing radiation codes for biomedical applications face the challenge of dealing with largely different spatial scales, from nanometer scales governing individual energy deposits to macroscopic scales of dose distributions in organs and tissues in ...
Pavel Kundrát +4 more
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Fushe yanjiu yu fushe gongyi xuebao, 2021 Five monolayer plasmid DNA films were irradiated by low-energy electrons (LEEs) (1~20 eV) in ultra-high vacuum. Crosslinks, single-strand breaks, double-strand breaks and the loss of the supercoiled configuration were analyzed via agarose gel ...
ZHUANG Puxiang +3 more
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Cells, 2021 Clusters of DNA damage, also called multiply damaged sites (MDS), are a signature of ionizing radiation exposure. They are defined as two or more lesions within one or two helix turns, which are created by the passage of a single radiation track.
Stanislav G. Kozmin +4 more
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Fushe yanjiu yu fushe gongyi xuebao, 2023 Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective ...
REN Junle +5 more
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Damage cluster distributions in numerical concrete at the mesoscale [PDF]
Physical Review E, 2017 We investigate the size distribution of damage clusters in concrete under uniaxial tension loading conditions. Using the finite-element method, the concrete is modeled at the mesoscale by a random distribution of elastic spherical aggregates within an elastic mortar paste.
Yilmaz, Okan +2 more
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