Results 1 to 10 of about 128,950 (259)
Multinomial probability model of radiation induced DSB and non-DSB clusters: tandem and bistranded damage clusters [PDF]
Scientific ReportsExperiments have shown that non-double strand break (DSB) clustered damage consisting of two or more base damages (BDs) or BD with single strand breaks (SSBs) occur with higher frequency than DSBs after ionizing radiation exposure.
Francis A. Cucinotta
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The Effects of Particle LET and Fluence on the Complexity and Frequency of Clustered DNA Damage
DNAMotivation: Clustered DNA-lesions are predominantly induced by ionizing radiation, particularly by high-LET particles, and considered as lethal damage. Quantification of this specific type of damage as a function of radiation parameters such as LET, dose
Mohammad Rezaee, Amitava Adhikary
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Quantifying DNA strand breaks from targeted alpha emitters 225Ac and 227Th via Geant4-DNA: implications for RBE and cell survival [PDF]
EJNMMI PhysicsBackground Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like 225Ac and 227Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage.
Samaneh Zolghadri +2 more
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Base-excision repair increases DNA double-strand break clustering within heavy-ion tracks and modulates repair at δ-electron-induced breaks [PDF]
Scientific ReportsSpace radiation poses a threat to human health during space missions. Its biological effect largely depends on heavy ions. These induce highly clustered DNA damage along their tracks, which is difficult to repair. If this damage is not repaired correctly,
Laura Schwan +3 more
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Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products [PDF]
Journal of Genetic Engineering and BiotechnologyIonizing radiation (IR) is a key cancer treatment, but its DNA-damaging effects, particularly double-strand breaks (DSBs) and clustered lesions, pose challenges for therapy.
Kouass Sahbani Saloua, Rayan M. Alansari
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SensorsGuided wave array-based structural health monitoring (SHM) is a promising solution for diagnosing damage in metal-connected structures. In this field, the reconstruction algorithm for probabilistic inspection (RAPID) is one of the most widely used ...
Qiao Bao +3 more
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Frontiers in Physics, 2021 Existing radiation codes for biomedical applications face the challenge of dealing with largely different spatial scales, from nanometer scales governing individual energy deposits to macroscopic scales of dose distributions in organs and tissues in ...
Pavel Kundrát +4 more
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Fushe yanjiu yu fushe gongyi xuebao, 2021 Five monolayer plasmid DNA films were irradiated by low-energy electrons (LEEs) (1~20 eV) in ultra-high vacuum. Crosslinks, single-strand breaks, double-strand breaks and the loss of the supercoiled configuration were analyzed via agarose gel ...
ZHUANG Puxiang +3 more
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Cells, 2021 Clusters of DNA damage, also called multiply damaged sites (MDS), are a signature of ionizing radiation exposure. They are defined as two or more lesions within one or two helix turns, which are created by the passage of a single radiation track.
Stanislav G. Kozmin +4 more
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Fushe yanjiu yu fushe gongyi xuebao, 2023 Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective ...
REN Junle +5 more
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