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Different types of DNA lesions forming in close vicinity, create clusters of damaged sites termed as “clustered/complex DNA damage” and they are considered to be a major challenge for DNA repair mechanisms resulting in significant repair delays and ...
Athanasia Pavlopoulou +8 more
doaj +1 more source
Cluster species and cluster size dependence of damage formation by cluster ion impact [PDF]
Molecular dynamics simulations of Ne, Ar and Xe clusters with various sizes impacting on Si surfaces were performed in order to study damage formation processes. When cluster size ranged from several tens to several thousands and accelerated energy is 20 keV in total, each cluster impact caused surface damage in the shape of a crater.
Aoki, Takaaki +3 more
openaire +3 more sources
Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. [PDF]
Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and
Akira Sassa +4 more
doaj +1 more source
Soils under spacio-temporally clustered events loading are susceptible to soil fatigue as pore pressure dissipates and the soil is unable to recover. This potential for damage from soil fatigue is identified through an induced seismic fatigue equation ...
Merissa L. Zuzulock +2 more
doaj +1 more source
AUTOMATED BUILDING SEGMENTATION AND DAMAGE ASSESSMENT FROM SATELLITE IMAGES FOR DISASTER RELIEF [PDF]
After a natural disaster or humanitarian crisis, rescue forces and relief organisations are dependent on fast, area-wide and accurate information on the damage caused to infrastructure and the situation on the ground. This study focuses on the assessment
X. Yuan +10 more
doaj +1 more source
The digitization of this collection was funded by a gift from EBSCO ...
CANNOT READ--DAMAGE
core +6 more sources
Biochemical mechanisms and clusters of damage for high-let radiation [PDF]
Using mechanisms of indirect and direct radiation, a generalized theory has been developed to account for strand break yields by high-LET particles. The major assumptions of this theory are: (i) damage at deoxyribose sites results primarily in strand break formation and (2) damage to bases leads to a variety of base alterations.
Chatterjee, A., Holley, W.R.
openaire +3 more sources
Assessing discriminative ability of risk models in clustered data. [PDF]
BACKGROUND: The discriminative ability of a risk model is often measured by Harrell's concordance-index (c-index). The c-index estimates for two randomly chosen subjects the probability that the model predicts a higher risk for the subject with poorer ...
van Klaveren, David +13 more
core +3 more sources
Oxidatively generated damage to DNA frequently appears in the human genome as the effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents, such as ionization radiation.
Bolesław T. Karwowski
doaj +1 more source

