Results 1 to 10 of about 3,146,198 (232)

Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy. [PDF]

Proc Natl Acad Sci U S A, 2022
Nakano T, Akamatsu K, Tsuda M, Tujimoto A, Hirayama R, Hiromoto T, Tamada T, Ide H, Shikazono N.   +8 more
europepmc   +2 more sources

Comprehensive database of track-structure simulations on DNA damage by H–Fe ions up to 1 GeV/u for space radiation biology [PDF]

Scientific Reports
Understanding biological effects of high-charge, high-energy (HZE) particles is critical for evaluating health risks of long-duration deep-space missions. To complement the scarce experimental data, PARTRAC track-structure simulations are reported on DNA
Chia-Wei Huang, Giorgio Baiocco, Pavel Kundrát   +2 more
doaj   +2 more sources

Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism

Fushe yanjiu yu fushe gongyi xuebao, 2023
Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective ...
REN Junle, GUO Xiaopeng, LEI Cairong, ZHANG Miaomiao, CHAI Ran, LU Dong   +5 more
doaj   +1 more source

Clustered DNA damages induced by low-energy (1~20 eV) electrons and the general mechanism of transient anions

Fushe yanjiu yu fushe gongyi xuebao, 2021
Five monolayer plasmid DNA films were irradiated by low-energy electrons (LEEs) (1~20 eV) in ultra-high vacuum. Crosslinks, single-strand breaks, double-strand breaks and the loss of the supercoiled configuration were analyzed via agarose gel ...
ZHUANG Puxiang, DONG Yanfang, SHAO Yu, ZHENG Yi   +3 more
doaj   +1 more source

Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. [PDF]

PLoS ONE, 2015
Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and
Akira Sassa, Nagisa Kamoshita, Yuki Kanemaru, Masamitsu Honma, Manabu Yasui   +4 more
doaj   +1 more source

In Silico Investigation of the Biological Implications of Complex DNA Damage with Emphasis in Cancer Radiotherapy through a Systems Biology Approach

Molecules, 2021
Different types of DNA lesions forming in close vicinity, create clusters of damaged sites termed as “clustered/complex DNA damage” and they are considered to be a major challenge for DNA repair mechanisms resulting in significant repair delays and ...
Athanasia Pavlopoulou, Seyedehsadaf Asfa, Evangelos Gioukakis, Ifigeneia V. Mavragani, Zacharenia Nikitaki, Işıl Takan, Jean-Pierre Pouget, Lynn Harrison, Alexandros G. Georgakilas   +8 more
doaj   +1 more source

Automated Image Analysis of Transmission Electron Micrographs: Nanoscale Evaluation of Radiation-Induced DNA Damage in the Context of Chromatin

Cells, 2023
Background: Heavy ion irradiation (IR) with high-linear energy transfer (LET) is characterized by a unique depth dose distribution and increased biological effectiveness.
Mutaz A. Abd Al-razaq, Anna Isermann, Markus Hecht, Claudia E. Rübe   +3 more
doaj   +1 more source

Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs

Frontiers in Cell and Developmental Biology, 2021
Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB).
Yeldar Baiken, Yeldar Baiken, Yeldar Baiken, Damira Kanayeva, Sabira Taipakova, Regina Groisman, Alexander A. Ishchenko, Dinara Begimbetova, Bakhyt Matkarimov, Murat Saparbaev, Murat Saparbaev   +10 more
doaj   +1 more source

Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage.

PLoS ONE, 2020
DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been aided by the use of sequence-specific endonucleases to
Nealia C M House, Ramya Parasuram, Jacob V Layer, Brendan D Price   +3 more
doaj   +1 more source

Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes. [PDF]

PLoS ONE, 2018
Due to its ability to induce DNA damage in a space and time controlled manner, ionising radiation is a unique tool for studying the mechanisms of DNA repair. The biological effectiveness of ionising radiation is related to the ionisation density which is
Lei Cheng, Beata Brzozowska, Alice Sollazzo, Lovisa Lundholm, Halina Lisowska, Siamak Haghdoost, Andrzej Wojcik   +6 more
doaj   +1 more source