Results 1 to 10 of about 168 (67)

Chromatin and the Cellular Response to Particle Radiation-Induced Oxidative and Clustered DNA Damage

Frontiers in Cell and Developmental Biology, 2022
Exposure to environmental ionizing radiation is prevalent, with greatest lifetime doses typically from high Linear Energy Transfer (high-LET) alpha particles via the radioactive decay of radon gas in indoor air.
John M. Danforth, Luc Provencher, Aaron A. Goodarzi   +2 more
doaj   +3 more sources

The Effects of Particle LET and Fluence on the Complexity and Frequency of Clustered DNA Damage

DNA
Motivation: Clustered DNA-lesions are predominantly induced by ionizing radiation, particularly by high-LET particles, and considered as lethal damage. Quantification of this specific type of damage as a function of radiation parameters such as LET, dose
Mohammad Rezaee, Amitava Adhikary
doaj   +3 more sources

Clustered DNA Damage: Electronic Properties and Their Influence on Charge Transfer. 7,8-Dihydro-8-Oxo-2′-Deoxyguaosine Versus 5′,8-Cyclo-2′-Deoxyadenosines: A Theoretical Approach

Cells, 2020
Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron−sulfur glycosylases (MutyH), which can recognize them by the ...
Boleslaw T. Karwowski
doaj   +3 more sources

Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism

Fushe yanjiu yu fushe gongyi xuebao, 2023
Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective ...
REN Junle, GUO Xiaopeng, LEI Cairong, ZHANG Miaomiao, CHAI Ran, LU Dong   +5 more
doaj   +1 more source

Clustered DNA damages induced by low-energy (1~20 eV) electrons and the general mechanism of transient anions

Fushe yanjiu yu fushe gongyi xuebao, 2021
Five monolayer plasmid DNA films were irradiated by low-energy electrons (LEEs) (1~20 eV) in ultra-high vacuum. Crosslinks, single-strand breaks, double-strand breaks and the loss of the supercoiled configuration were analyzed via agarose gel ...
ZHUANG Puxiang, DONG Yanfang, SHAO Yu, ZHENG Yi   +3 more
doaj   +1 more source

Dissecting Highly Mutagenic Processing of Complex Clustered DNA Damage in Yeast Saccharomyces cerevisiae

Cells, 2021
Clusters of DNA damage, also called multiply damaged sites (MDS), are a signature of ionizing radiation exposure. They are defined as two or more lesions within one or two helix turns, which are created by the passage of a single radiation track.
Stanislav G. Kozmin, Gregory Eot-Houllier, Anne Reynaud-Angelin, Didier Gasparutto, Evelyne Sage   +4 more
doaj   +1 more source

Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. [PDF]

PLoS ONE, 2015
Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and
Akira Sassa, Nagisa Kamoshita, Yuki Kanemaru, Masamitsu Honma, Manabu Yasui   +4 more
doaj   +1 more source

In Silico Investigation of the Biological Implications of Complex DNA Damage with Emphasis in Cancer Radiotherapy through a Systems Biology Approach

Molecules, 2021
Different types of DNA lesions forming in close vicinity, create clusters of damaged sites termed as “clustered/complex DNA damage” and they are considered to be a major challenge for DNA repair mechanisms resulting in significant repair delays and ...
Athanasia Pavlopoulou, Seyedehsadaf Asfa, Evangelos Gioukakis, Ifigeneia V. Mavragani, Zacharenia Nikitaki, Işıl Takan, Jean-Pierre Pouget, Lynn Harrison, Alexandros G. Georgakilas   +8 more
doaj   +1 more source

The Influence of Single, Tandem, and Clustered DNA Damage on the Electronic Properties of the Double Helix: A Theoretical Study

Molecules, 2020
Oxidatively generated damage to DNA frequently appears in the human genome as the effect of aerobic metabolism or as the result of exposure to exogenous oxidizing agents, such as ionization radiation.
Bolesław T. Karwowski
doaj   +1 more source

Automated Image Analysis of Transmission Electron Micrographs: Nanoscale Evaluation of Radiation-Induced DNA Damage in the Context of Chromatin

Cells, 2023
Background: Heavy ion irradiation (IR) with high-linear energy transfer (LET) is characterized by a unique depth dose distribution and increased biological effectiveness.
Mutaz A. Abd Al-razaq, Anna Isermann, Markus Hecht, Claudia E. Rübe   +3 more
doaj   +1 more source