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Quantification of complex DNA damage by ionising radiation: An experimental and theoretical approach [PDF]
, 2000 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Ionising radiation potentially produces a broad spectrum of damage in DNA including single and double strand breaks (ssb and dsb) and base damages.
Fulford, Jonathan
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Identifying a role for Ciz1 in the DNA damage response [PDF]
, 2011 In proliferating cells, cell cycle arrest and DNA repair are induced upon detection of DNA damage. The DNA damage response (DDR) to double strand DNA breaks is mediated by phosphatidylinositol 3-kinase-like protein kinases (PIKKs), which propagate DDR ...
Roper, Katherine
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Comprehensive database of track-structure simulations on DNA damage by H–Fe ions up to 1 GeV/u for space radiation biology [PDF]
Scientific ReportsUnderstanding biological effects of high-charge, high-energy (HZE) particles is critical for evaluating health risks of long-duration deep-space missions. To complement the scarce experimental data, PARTRAC track-structure simulations are reported on DNA
Chia-Wei Huang +2 more
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Repair of clustered uracil DNA damages in Escherichia coli [PDF]
Nucleic Acids Research, 2003 Multiply damaged sites (MDS) are defined as greater than/equal to two lesions within 10-15 bp and are generated in DNA by ionizing radiation. In vitro repair of closely opposed base damages > or =2 bp apart results in a double strand break (DSB). This work extends the in vitro studies by utilizing clusters of uracil DNA damage as model lesions to ...
Dwain I, D'souza, Lynn, Harrison
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DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]
, 2002 Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D. +3 more
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PLoS ONE, 2020 DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been aided by the use of sequence-specific endonucleases to
Nealia C M House +3 more
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Frontiers in Cell and Developmental Biology, 2021 Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB).
Yeldar Baiken +10 more
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Analysis of the Isolated and the Clustered DNA Damages by Single-Molecule Counting [PDF]
Analytical Chemistry, 2019 DNA damage seriously threats the genomic stability and is linked to mutagenesis, carcinogenesis, and cell death. DNA damage includes the isolated damage and the clustered damages, but few approaches are available for efficient detection of the clustered damage due to its spatial distribution.
Yan Zhang, Ruo-nan Hua, Chun-yang Zhang
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Repair of clustered abasic DNA damages
The FASEB Journal, 2007 Abasic clusters‐‐two or more abasic sites on opposing strands within one helical turn‐‐are induced in DNA by ionizing radiation. AP sites are recognized by AP endonucleases, which incise the DNA at the modified site and initiate further repair. Previous studies show the action of these enzymes on one or two lesions.
Brigitte Katrin Paap, Betsy M Sutherland
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Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes. [PDF]
PLoS ONE, 2018 Due to its ability to induce DNA damage in a space and time controlled manner, ionising radiation is a unique tool for studying the mechanisms of DNA repair. The biological effectiveness of ionising radiation is related to the ionisation density which is
Lei Cheng +6 more
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