Results 21 to 30 of about 163,016 (283)
Fushe yanjiu yu fushe gongyi xuebao, 2023 Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective ...
REN Junle +5 more
doaj +1 more source
Fushe yanjiu yu fushe gongyi xuebao, 2021 Five monolayer plasmid DNA films were irradiated by low-energy electrons (LEEs) (1~20 eV) in ultra-high vacuum. Crosslinks, single-strand breaks, double-strand breaks and the loss of the supercoiled configuration were analyzed via agarose gel ...
ZHUANG Puxiang +3 more
doaj +1 more source
Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. [PDF]
PLoS ONE, 2015 Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and
Akira Sassa +4 more
doaj +1 more source
Molecules, 2021 Different types of DNA lesions forming in close vicinity, create clusters of damaged sites termed as “clustered/complex DNA damage” and they are considered to be a major challenge for DNA repair mechanisms resulting in significant repair delays and ...
Athanasia Pavlopoulou +8 more
doaj +1 more source
Saccharomyces cerevisiae-based system for studying clustered DNA damages [PDF]
Radiation and Environmental Biophysics, 2010 DNA-damaging agents can induce clustered lesions or multiply damaged sites (MDSs) on the same or opposing DNA strands. In the latter, attempts to repair MDS can generate closely opposed single-strand break intermediates that may convert non-lethal or mutagenic base damage into double-strand breaks (DSBs). We constructed a diploid S.
Moscariello, Mario, Sutherland, Betsy
openaire +2 more sources
Repair of clustered uracil DNA damages in Escherichia coli [PDF]
Nucleic Acids Research, 2003 Multiply damaged sites (MDS) are defined as greater than/equal to two lesions within 10-15 bp and are generated in DNA by ionizing radiation. In vitro repair of closely opposed base damages > or =2 bp apart results in a double strand break (DSB). This work extends the in vitro studies by utilizing clusters of uracil DNA damage as model lesions to ...
Dwain I, D'souza, Lynn, Harrison
openaire +2 more sources
Clustered DNA damage induced by protons radiation in plasmid DNA [PDF]
Chinese Science Bulletin, 2013 Clustered DNA damage is considered as a critical type of lesions induced by ionizing radiation, which can be converted into the fatal or strong mutagenic complex double strand breaks (DSBs) during damage processing in the cells. The new data show that high energy protons produce more potentially lethal DSBs than low LET radiation.
Sui, Li +5 more
openaire +1 more source
Cells, 2023 Background: Heavy ion irradiation (IR) with high-linear energy transfer (LET) is characterized by a unique depth dose distribution and increased biological effectiveness.
Mutaz A. Abd Al-razaq +3 more
doaj +1 more source
DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]
, 2020 Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W +10 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB).
Yeldar Baiken +10 more
doaj +1 more source