Quantification of complex DNA damage by ionising radiation: An experimental and theoretical approach [PDF]
, 2000 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Ionising radiation potentially produces a broad spectrum of damage in DNA including single and double strand breaks (ssb and dsb) and base damages.
Fulford, Jonathan
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DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]
, 2002 Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D. +3 more
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Visualization of complex DNA damage along accelerated ions tracks
EPJ Web of Conferences, 2018 The most deleterious DNA lesions induced by ionizing radiation are clustered DNA double-strand breaks (DSB). Clustered or complex DNA damage is a combination of a few simple lesions (single-strand breaks, base damage etc.) within one or two DNA helix ...
Kulikova Elena +5 more
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Frontiers in Physics, 2021 Existing radiation codes for biomedical applications face the challenge of dealing with largely different spatial scales, from nanometer scales governing individual energy deposits to macroscopic scales of dose distributions in organs and tissues in ...
Pavel Kundrát +4 more
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The Ability of Cyanobacterial Cells to Restore UV-B Radiation Induced Damage to Photosystem II is Influenced by Photolyase Dependent DNA Repair [PDF]
, 2013 Damage of DNA and Photosystem-II are among the most significant effects of UV-B irradiation in photosynthetic organisms. Both damaged DNA and Photosystem-II can be repaired, which represent important defense mechanisms against detrimental UV-B effects ...
Sass, László +5 more
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Oxidatively generated complex DNA damage: Tandem and clustered lesions
, 2012 There is an increasing interest for oxidatively generated complex lesions that are potentially more detrimental than single oxidized nucleobases. In this survey, the recently available information on the formation and processing of several classes of ...
Menoni, Hervé +4 more
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Frontiers in Oncology, 2021 The impact of a mixed neutron-gamma beam on the activation of DNA damage response (DDR) proteins and non-coding RNAs (ncRNAs) is poorly understood.
Kamila Maliszewska-Olejniczak +5 more
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A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. [PDF]
, 2011 BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks
Valentine, Jane M. +11 more
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Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity. [PDF]
, 2012 The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation.
Hilmar Strickfaden (148181) +47 more
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Which DNA Damage is Likely to Be Relevant in Hormetic Responses?
Dose-Response, 2008 Working under the assumption that hormesis is triggered by specific types of DNA damage, this report focuses on the types of damage which form the signature of ionizing radiation.
William A. Bernhard +2 more
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