Results 21 to 30 of about 86,380 (239)
Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. [PDF]
PLoS ONE, 2015 Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and
Akira Sassa +4 more
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Molecules, 2021 Different types of DNA lesions forming in close vicinity, create clusters of damaged sites termed as “clustered/complex DNA damage” and they are considered to be a major challenge for DNA repair mechanisms resulting in significant repair delays and ...
Athanasia Pavlopoulou +8 more
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Repair of clustered uracil DNA damages in Escherichia coli [PDF]
Nucleic Acids Research, 2003 Multiply damaged sites (MDS) are defined as greater than/equal to two lesions within 10-15 bp and are generated in DNA by ionizing radiation. In vitro repair of closely opposed base damages > or =2 bp apart results in a double strand break (DSB). This work extends the in vitro studies by utilizing clusters of uracil DNA damage as model lesions to ...
Dwain I, D'souza, Lynn, Harrison
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Cells, 2023 Background: Heavy ion irradiation (IR) with high-linear energy transfer (LET) is characterized by a unique depth dose distribution and increased biological effectiveness.
Mutaz A. Abd Al-razaq +3 more
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Frontiers in Cell and Developmental Biology, 2021 Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB).
Yeldar Baiken +10 more
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PLoS ONE, 2020 DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been aided by the use of sequence-specific endonucleases to
Nealia C M House +3 more
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Saccharomyces cerevisiae-based system for studying clustered DNA damages [PDF]
Radiation and Environmental Biophysics, 2010 DNA-damaging agents can induce clustered lesions or multiply damaged sites (MDSs) on the same or opposing DNA strands. In the latter, attempts to repair MDS can generate closely opposed single-strand break intermediates that may convert non-lethal or mutagenic base damage into double-strand breaks (DSBs). We constructed a diploid S.
Moscariello, Mario, Sutherland, Betsy
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Analysis of the Isolated and the Clustered DNA Damages by Single-Molecule Counting [PDF]
Analytical Chemistry, 2019 DNA damage seriously threats the genomic stability and is linked to mutagenesis, carcinogenesis, and cell death. DNA damage includes the isolated damage and the clustered damages, but few approaches are available for efficient detection of the clustered damage due to its spatial distribution.
Yan Zhang, Ruo-nan Hua, Chun-yang Zhang
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Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes. [PDF]
PLoS ONE, 2018 Due to its ability to induce DNA damage in a space and time controlled manner, ionising radiation is a unique tool for studying the mechanisms of DNA repair. The biological effectiveness of ionising radiation is related to the ionisation density which is
Lei Cheng +6 more
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Repair of clustered abasic DNA damages
The FASEB Journal, 2007 Abasic clusters‐‐two or more abasic sites on opposing strands within one helical turn‐‐are induced in DNA by ionizing radiation. AP sites are recognized by AP endonucleases, which incise the DNA at the modified site and initiate further repair. Previous studies show the action of these enzymes on one or two lesions.
Brigitte Katrin Paap, Betsy M Sutherland
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