Results 31 to 40 of about 163,016 (283)

Clustered DNA Damages induced by 0.5 to 30 eV Electrons [PDF]

open access: yesInternational Journal of Molecular Sciences, 2019
Low-energy electrons (LEEs) of energies ≤30 eV are generated in large quantities by ionizing radiation. These electrons can damage DNA; particularly, they can induce the more detrimental clustered lesions in cells. This type of lesions, which are responsible for a large portion of the genotoxic stress generated by ionizing radiation, is described in ...
Yi Zheng, Léon Sanche
openaire   +2 more sources

Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage.

open access: yesPLoS ONE, 2020
DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been aided by the use of sequence-specific endonucleases to
Nealia C M House   +3 more
doaj   +1 more source

Repair of clustered abasic DNA damages

open access: yesThe FASEB Journal, 2007
Abasic clusters‐‐two or more abasic sites on opposing strands within one helical turn‐‐are induced in DNA by ionizing radiation. AP sites are recognized by AP endonucleases, which incise the DNA at the modified site and initiate further repair. Previous studies show the action of these enzymes on one or two lesions.
Brigitte Katrin Paap, Betsy M Sutherland
openaire   +1 more source

High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core "DSB" response specific to clastogenic treatments. [PDF]

open access: yes, 2014
Plants exhibit a robust transcriptional response to gamma radiation which includes the induction of transcripts required for homologous recombination and the suppression of transcripts that promote cell cycle progression.
Britt, Anne B   +4 more
core   +2 more sources

Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes. [PDF]

open access: yesPLoS ONE, 2018
Due to its ability to induce DNA damage in a space and time controlled manner, ionising radiation is a unique tool for studying the mechanisms of DNA repair. The biological effectiveness of ionising radiation is related to the ionisation density which is
Lei Cheng   +6 more
doaj   +1 more source

Clustered DNA damage induced by heavy ion particles

open access: yesBiological Sciences in Space, 2004
Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical ...
Hiroaki, Terato, Hiroshi, Ide
openaire   +3 more sources

Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana. [PDF]

open access: yes, 2014
Low linear energy transfer (LET) gamma rays and high LET HZE (high atomic weight, high energy) particles act as powerful mutagens in both plants and animals.
Britt, Anne B   +4 more
core   +1 more source

Coupling Radiation Transport and Track-Structure Simulations: Strategy Based on Analytical Formulas Representing DNA Damage Yields

open access: yesFrontiers in Physics, 2021
Existing radiation codes for biomedical applications face the challenge of dealing with largely different spatial scales, from nanometer scales governing individual energy deposits to macroscopic scales of dose distributions in organs and tissues in ...
Pavel Kundrát   +4 more
doaj   +1 more source

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas [PDF]

open access: yes, 2018
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with ...
Abdel-Rahman, Mohamed H.   +784 more
core   +2 more sources

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox [PDF]

open access: yes, 2020
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead to ...
Almeida, Sérgio F. de   +3 more
core   +4 more sources

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