Results 31 to 40 of about 2,975,365 (268)
Saccharomyces cerevisiae-based system for studying clustered DNA damages [PDF]
Radiation and Environmental Biophysics, 2010 DNA-damaging agents can induce clustered lesions or multiply damaged sites (MDSs) on the same or opposing DNA strands. In the latter, attempts to repair MDS can generate closely opposed single-strand break intermediates that may convert non-lethal or mutagenic base damage into double-strand breaks (DSBs). We constructed a diploid S.
Moscariello, Mario, Sutherland, Betsy
openaire +2 more sources
Visualization of complex DNA damage along accelerated ions tracks
EPJ Web of Conferences, 2018 The most deleterious DNA lesions induced by ionizing radiation are clustered DNA double-strand breaks (DSB). Clustered or complex DNA damage is a combination of a few simple lesions (single-strand breaks, base damage etc.) within one or two DNA helix ...
Kulikova Elena +5 more
doaj +1 more source
Frontiers in Physics, 2021 Existing radiation codes for biomedical applications face the challenge of dealing with largely different spatial scales, from nanometer scales governing individual energy deposits to macroscopic scales of dose distributions in organs and tissues in ...
Pavel Kundrát +4 more
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Clustered DNA damage induced by heavy ion particles
Biological Sciences in Space, 2004 Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical ...
Terato, Hiroaki, Ide, Hiroshi
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The Ability of Cyanobacterial Cells to Restore UV-B Radiation Induced Damage to Photosystem II is Influenced by Photolyase Dependent DNA Repair [PDF]
, 2013 Damage of DNA and Photosystem-II are among the most significant effects of UV-B irradiation in photosynthetic organisms. Both damaged DNA and Photosystem-II can be repaired, which represent important defense mechanisms against detrimental UV-B effects ...
Sass, László +5 more
core +1 more source
Frontiers in Oncology, 2021 The impact of a mixed neutron-gamma beam on the activation of DNA damage response (DDR) proteins and non-coding RNAs (ncRNAs) is poorly understood.
Kamila Maliszewska-Olejniczak +5 more
doaj +1 more source
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]
, 2008 Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Fisher, LM +7 more
core +1 more source
Which DNA Damage is Likely to Be Relevant in Hormetic Responses?
Dose-Response, 2008 Working under the assumption that hormesis is triggered by specific types of DNA damage, this report focuses on the types of damage which form the signature of ionizing radiation.
William A. Bernhard +2 more
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Clustered DNA Damages induced by 0.5 to 30 eV Electrons [PDF]
International Journal of Molecular Sciences, 2019 Low-energy electrons (LEEs) of energies ≤30 eV are generated in large quantities by ionizing radiation. These electrons can damage DNA; particularly, they can induce the more detrimental clustered lesions in cells. This type of lesions, which are responsible for a large portion of the genotoxic stress generated by ionizing radiation, is described in ...
Yi Zheng, Léon Sanche
openaire +2 more sources
Frontiers in Genetics, 2019 The evolution of organisms has provided a variety of mechanisms to maintain the integrity of its genome, but as damage occurs, DNA damage repair pathways are necessary to resolve errors.
Xi-Dian Tang +5 more
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