Results 31 to 40 of about 86,380 (239)
Frontiers in Physics, 2021 Existing radiation codes for biomedical applications face the challenge of dealing with largely different spatial scales, from nanometer scales governing individual energy deposits to macroscopic scales of dose distributions in organs and tissues in ...
Pavel Kundrát +4 more
doaj +1 more source
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK. [PDF]
Nucleic Acids Res, 2013 DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2AX is a key step in facilitating efficient DSB repair ...
Meyer B +5 more
europepmc +5 more sources
Visualization of complex DNA damage along accelerated ions tracks
EPJ Web of Conferences, 2018 The most deleterious DNA lesions induced by ionizing radiation are clustered DNA double-strand breaks (DSB). Clustered or complex DNA damage is a combination of a few simple lesions (single-strand breaks, base damage etc.) within one or two DNA helix ...
Kulikova Elena +5 more
doaj +1 more source
Frontiers in Oncology, 2021 The impact of a mixed neutron-gamma beam on the activation of DNA damage response (DDR) proteins and non-coding RNAs (ncRNAs) is poorly understood.
Kamila Maliszewska-Olejniczak +5 more
doaj +1 more source
Clustered DNA damage induced by heavy ion particles
Biological Sciences in Space, 2004 Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical ...
Terato, Hiroaki, Ide, Hiroshi
openaire +3 more sources
Clustered DNA Damages induced by 0.5 to 30 eV Electrons [PDF]
International Journal of Molecular Sciences, 2019 Low-energy electrons (LEEs) of energies ≤30 eV are generated in large quantities by ionizing radiation. These electrons can damage DNA; particularly, they can induce the more detrimental clustered lesions in cells. This type of lesions, which are responsible for a large portion of the genotoxic stress generated by ionizing radiation, is described in ...
Yi Zheng, Léon Sanche
openaire +2 more sources
Which DNA Damage is Likely to Be Relevant in Hormetic Responses?
Dose-Response, 2008 Working under the assumption that hormesis is triggered by specific types of DNA damage, this report focuses on the types of damage which form the signature of ionizing radiation.
William A. Bernhard +2 more
doaj +1 more source
Order effect of repair processes to clustered DNA damage [PDF]
J Radiat Res, 2014 In a living cell, a multiply damaged site in DNA is thought to be processed by several different pathways simultaneously or sequentially. Under this situation, the cellular response to the lesion cluster might depend on the order of repair processes because the configuration of the lesions will be modified by the reaction of initial repair protein ...
Shiraishi I +4 more
europepmc +3 more sources
Frontiers in Genetics, 2019 The evolution of organisms has provided a variety of mechanisms to maintain the integrity of its genome, but as damage occurs, DNA damage repair pathways are necessary to resolve errors.
Xi-Dian Tang +5 more
doaj +1 more source
Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny. [PDF]
PLoS ONE, 2012 Poor local control and tumor escape are of major concern in head-and-neck cancers treated by conventional radiotherapy or hadrontherapy. Reduced glutathione (GSH) is suspected of playing an important role in mechanisms leading to radioresistance, and its
Maïté Hanot +8 more
doaj +1 more source