Results 51 to 60 of about 163,016 (283)

Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]

, 2012
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Brandt, Tobias, Freund, Stefan M. V., Teufel, Daniel P., Townsley, Fiona M., Veprintsev, Dmitry B.   +4 more
core   +10 more sources

Calculation of complex DNA damage induced by ions

, 2011
This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The analysis and assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be ...
Gallagher, David C., Solov'yov, Andrey V., Surdutovich, Eugene   +2 more
core   +1 more source

Expression profiling of key pathways in rat liver after a one-year feeding trial with transgenic maize MON810 [PDF]

, 2019
In a recent one-year feeding study, we observed no adverse effects on tissue level in organs of rats fed with the genetically-modified maize MON810. Here, we assessed RNA expression levels of 86 key genes of the apoptosis-, NF-кB-, DNA-damage response ...
Bohmer, Marc, Einspanier, Ralf, Ran, Guangyao, Sharbati, Soroush, Stein, Thorsten   +4 more
core   +1 more source

DNA Damage and Radical Reactions: Mechanistic Aspects, Formation in Cells and Repair Studies

CHIMIA, 2008
Several examples of oxidative and reductive reactions of DNA components that lead to single and tandem modifications are discussed in this review.
Jean Cadet, Thomas Carell, Luciano Cellai, Chryssostomos Chatgilialoglu, Thanasis Gimisis, Miguel Miranda, Peter O'Neill, Jean-Luc Ravanat, Marc Robert   +8 more
doaj   +1 more source

Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency. [PDF]

PLoS ONE, 2016
XPC-RAD23B (XPC) plays a critical role in human nucleotide excision repair (hNER) as this complex recognizes DNA adducts to initiate NER. To determine the mutagenic potential of structurally different bulky DNA damages, various studies have been ...
Benjamin Hilton, Sathyaraj Gopal, Lifang Xu, Sharmistha Mazumder, Phillip R Musich, Bongsup P Cho, Yue Zou   +6 more
doaj   +1 more source

Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage [PDF]

, 2019
Dental calculus, calcified oral plaque biofilm, contains microbial and host biomolecules that can be used to study historic microbiome communities and host responses.
CJ Adler, C Warinner, C Warinner, S Buckley, IM Velsko, J Hendy, ID Mandel, C Warinner, C Walker, V Zijnge, P Ramberg, D Belstrøm, PE Kolenbrander, WG Wade, SS Socransky, IM Velsko, SC Holt, M Umeda, BH Mullally, JW Lee, IM Velsko, LM Shaddox, AW Aruni, KL Cross, L Albayrak, S Yost, VM Barnes, JL Ebersole, S Yost, P Jorth, A Basic, RR Jersie-Christensen, T Imamura, LS Weyrich, AA Ribeiro, EL Gross, A Simón-Soro, Zachary D. Moye, O Manor, SM Dabdoub, D Belstrøm, RC Page, S Hillson, A Ogden, S Brooks, JL Buckberry, D Ferembach, CO Lovejoy, TW Phenice, LAF Frantz, P Skoglund, P Skoglund, M. Meyer, A Ginolhac, H Jónsson, A Peltzer, M Schubert, H Li, H Li, M Meyer, D Knights, N Segata, DT Truong, DH Parks, DH Parks, M Bastian, R Overbeek, DH Huson, MC Chambers, FE Dewhirst   +69 more
core   +4 more sources

Chemical Aspects of Clustered DNA Damage Induction by Ionising Radiation

Radiation Protection Dosimetry, 2002
Ionising radiation induces a variety of chemical modifications to DNA, ranging from simple, isolated lesions to clustered DNA damage, in which two or more lesions are formed within a few tens of base pairs by a single radiation track. Multiple lesions, e.g. tandem lesions and amplification of damage, may also be induced in DNA by reaction with a single
Lomax, M, Gulston, M, O'Neill, P
openaire   +3 more sources

Multiscale approach to radiation damage induced by ion beams: complex DNA damage and effects of thermal spikes

, 2010
We present the latest advances of the multiscale approach to radiation damage caused by irradiation of a tissue with energetic ions and report the most recent advances in the calculations of complex DNA damage and the effects of thermal spikes on ...
Solov'yov, A. V., Surdutovich, E., Yakubovich, A. V.   +2 more
core   +1 more source

Analysis of acid-stressed Bacillus cereus reveals a major oxidative response and inactivation-associated radical formation [PDF]

, 2010
Acid stress resistance of the food-borne human pathogen Bacillus cereus may contribute to its survival in acidic environments, such as encountered in soil, food and the human gastrointestinal tract. The acid stress responses of B.
Abee, T., Kranenburg, R., van, Melis, C.C.J., van, Moezelaar, R., Mols, J.M.   +4 more
core   +2 more sources

Significance of DNA polymerase I in in vivo processing of clustered DNA damage

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2013
We examined the biological consequences of bi-stranded clustered damage sites, consisting of a combination of DNA lesions, such as a 1-nucleotide gap (GAP), an apurinic/apyrimidinic (AP) site, and an 8-oxo-7,8-dihydroguanine (8-oxoG), using a bacterial plasmid-based assay.
Shikazono, N, Akamatsu, K, Takahashi, M, Noguchi, M, Urushibara, A, O'Neill, P, Yokoya, A   +6 more
openaire   +4 more sources