Results 41 to 50 of about 1,705,145 (242)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Time-Resolved Repair of Clustered DNA Damage in γ-Irradiated Yeast Cells

DNA
Background/Objectives: Exposure of cells to ionizing radiation induces isolated DNA lesions, including single-strand breaks, apurinic/apyrimidinic sites, and oxidized bases, as well as clustered damages of different complexity. The latter types of damage
Ana G. Sánchez, Deborah J. Keszenman
doaj   +1 more source

Repair of clustered abasic DNA damages

The FASEB Journal, 2007
Abasic clusters‐‐two or more abasic sites on opposing strands within one helical turn‐‐are induced in DNA by ionizing radiation. AP sites are recognized by AP endonucleases, which incise the DNA at the modified site and initiate further repair. Previous studies show the action of these enzymes on one or two lesions.
Brigitte Katrin Paap, Betsy M Sutherland
openaire   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Plasmid DNA damage by heavy ions at spread-out Bragg peak energies [PDF]

, 2010
Interaction of ionizing radiation with plasmid DNA can lead to formation of single strand breaks, double strand breaks and clustered lesions. We have investigated the response of the synthetic plasmid pBR322 in aqueous solution upon irradiation with (12 ...
H. M. Dang, T. Schlathölter, Hoekstra, R.; id_orcid, van Goethem, M. J., Schlatholter, T.; id_orcid, Hoekstra, R., Schlatholter, T., Brandenburg, S.; id_orcid, M. J. van Goethem, S. Brandenburg, E. R. van der Graaf, van der Graaf, E. R., Dang, H. M., Brandenburg, S., R. Hoekstra   +14 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Multinomial probability model of radiation induced DSB and non-DSB clusters: tandem and bistranded damage clusters

Scientific Reports
Experiments have shown that non-double strand break (DSB) clustered damage consisting of two or more base damages (BDs) or BD with single strand breaks (SSBs) occur with higher frequency than DSBs after ionizing radiation exposure.
Francis A. Cucinotta
doaj   +1 more source

Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy

Frontiers in Oncology, 2021
The impact of a mixed neutron-gamma beam on the activation of DNA damage response (DDR) proteins and non-coding RNAs (ncRNAs) is poorly understood.
Kamila Maliszewska-Olejniczak, Damian Kaniowski, Martyna Araszkiewicz, Martyna Araszkiewicz, Katarzyna Tymińska, Agnieszka Korgul   +5 more
doaj   +1 more source

MN-pair Contrastive Damage Representation and Clustering for Prognostic Explanation

Proceedings of the International Symposium on Automation and Robotics in Construction (IAARC), 2023
For infrastructure inspections, damage representation does not constantly match the predefined classes of damage grade, resulting in detailed clusters of unseen damages or more complex clusters from overlapped space between two grades. The damage representation has fundamentally complex features; consequently, not all the damage classes can be ...
Takato Yasuno, Masahiro Okano, Junichiro Fujii   +2 more
openaire   +2 more sources

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

, 2011
Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger carcinogenic events for reasons that are not well understood. Here, we used an in situ method to directly monitor induction and repair of clustered DNA lesions in ...
Aroumougame Asaithamby, David J. Chen, Burong Hu   +2 more
core   +1 more source