Results 61 to 70 of about 1,705,145 (242)
, 2000 Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damage, which are thought to reflect the biological severity. Escherichia coli Nth and Fpg and nuclear extracts from XRS5, a Chinese hamster ovary Ku-deficient cell line, have ...
Laval, J +2 more
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Damage-Cluster Distributions and Size Effect on Strength in Compressive Failure [PDF]
Physical Review Letters, 2012 We investigate compressive failure of heterogeneous materials on the basis of a continuous progressive damage model. The model explicitely accounts for tensile and shear local damage and reproduces the main features of compressive failure of brittle materials like rocks or ice.
Girard, Lucas +2 more
openaire +6 more sources
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Environmental Research CommunicationsNon-grain production of cultivated land (NGPCL) threatened food security. Therefore, scholars have begun study this area in China and other countries, but most of the studies have focused on large scales, and few studies have focused on plot scale ...
Chenhui Zhu +7 more
doaj +1 more source
Reference‐Free Damage Classification Based on Cluster Analysis
Computer-Aided Civil and Infrastructure Engineering, 2008 Fiber-reinforced polymer (FRP) composite materials have been used widely for retrofitting of civil infrastructure systems. The ultimate aim of this work was to develop an on-site non-destructive testing (NDT) technique that can continuously and autonomously inspect the bonding condition between a carbon FRP (CFRP) layer and a host reinforced concrete ...
Hoon Sohn, Seung Dae Kim, Kent Harries
openaire +2 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny. [PDF]
PLoS ONE, 2012 Poor local control and tumor escape are of major concern in head-and-neck cancers treated by conventional radiotherapy or hadrontherapy. Reduced glutathione (GSH) is suspected of playing an important role in mechanisms leading to radioresistance, and its
Maïté Hanot +8 more
doaj +1 more source
A nanodosimetric model of radiation-induced clustered DNA damage yields
, 2010 International audienceWe present a nanodosimetric model for predicting the yield of double strand breaks (DSBs) and non-DSB clustered damages induced in irradiated DNA.
Bashkirov, V. +9 more
core +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source