Results 61 to 70 of about 1,732,242 (271)

Study on the spatial differentiation and driving factors of ‘Non-grain’ of cultivated land in Anyuan county

Environmental Research Communications
Non-grain production of cultivated land (NGPCL) threatened food security. Therefore, scholars have begun study this area in China and other countries, but most of the studies have focused on large scales, and few studies have focused on plot scale ...
Chenhui Zhu, Henggang Zhang, Yonglin Chen, Tianyu Jiao, Qun Luo, Hang Zhou, Yunping Zhang, Xu Ma   +7 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny. [PDF]

PLoS ONE, 2012
Poor local control and tumor escape are of major concern in head-and-neck cancers treated by conventional radiotherapy or hadrontherapy. Reduced glutathione (GSH) is suspected of playing an important role in mechanisms leading to radioresistance, and its
Maïté Hanot, Anthony Boivin, Céline Malésys, Michaël Beuve, Anthony Colliaux, Nicolas Foray, Thierry Douki, Dominique Ardail, Claire Rodriguez-Lafrasse   +8 more
doaj   +1 more source

Clustered DNA damage induced by heavy ion particles

Biological Sciences in Space, 2004
Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical ...
Terato, Hiroaki, Ide, Hiroshi
openaire   +3 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Reference‐Free Damage Classification Based on Cluster Analysis

Computer-Aided Civil and Infrastructure Engineering, 2008
Fiber-reinforced polymer (FRP) composite materials have been used widely for retrofitting of civil infrastructure systems. The ultimate aim of this work was to develop an on-site non-destructive testing (NDT) technique that can continuously and autonomously inspect the bonding condition between a carbon FRP (CFRP) layer and a host reinforced concrete ...
Hoon Sohn, Seung Dae Kim, Kent Harries
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Quantifying DNA strand breaks from targeted alpha emitters 225Ac and 227Th via Geant4-DNA: implications for RBE and cell survival

EJNMMI Physics
Background Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like 225Ac and 227Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage.
Samaneh Zolghadri, Payman Rafiepour, Hassan Yousefnia   +2 more
doaj   +1 more source