Results 81 to 90 of about 1,705,145 (242)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Localized attack on networks with clustering
New Journal of Physics, 2019 Network systems with clustering have been given much attention due to their wide occurrence in the real world. One focus of these studies has been on robustness of single clustered networks and interdependent clustered networks under random attack (RA ...
Gaogao Dong +7 more
doaj +1 more source
A solver for clustered low-rank SDPs arising from multivariate polynomial (matrix) programs
, 2021 In this thesis, we give a primal-dual interior point method specialized to clustered low-rank semidefinite programs. We introduce multivariate polynomial matrix programs, and we reduce these to clustered low-rank semidefinite programs.
Leijenhorst, Nando (author)
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
RadiationProton therapy offers superior dose localization, yet the biological effects of low-energy protons relevant to superficial tissues remain underexplored. We report the design and validation of a proton irradiation setup developed at the Tandem Accelerator
Spyridon Zonitsas +13 more
doaj +1 more source
Simple and complex clustered DNA damage represent the critical initial damage caused by radiation. In this paper, a multinomial probability model of clustered damage is developed with probabilities dependent on the energy imparted to DNA and surrounding ...
Francis A. Cucinotta
core +1 more source
Clustered DNA damage in irradiated human diploid fibroblasts: influence of chromatin organization
, 2010 Clustered DNA damages are induced by ionizing radiation and are defined as two or more lesions within one or two helical turns. The aim of this study was to investigate the induction and repair of clustered DNA damage in cells with emphasis on the ...
Hultborn, Ragnar, +3 more
core +1 more source
Exact algorithms for the clustered vehicle routing problem [PDF]
, 2014 This study presents new exact algorithms for the Clustered Vehicle Routing Problem (CluVRP). The CluVRP is a generalization of the Capacitated Vehicle Routing Problem (CVRP), in which the customers are grouped into clusters.
Vigo, Daniele +9 more
core +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source