Results 101 to 110 of about 1,705,145 (242)

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences

International Journal of COPD, 2011
Viktor M Pastukh1, Li Zhang2, Mykhaylo V Ruchko1, Olena Gorodnya1, Gina C Bardwell1, Rubin M Tuder2, Mark N Gillespie11Department of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, AL, USA; 2Program in ...
Viktor M Pastukh, Li Zhang, Mykhaylo V Ruchko, et al   +3 more
doaj  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Base-excision repair increases DNA double-strand break clustering within heavy-ion tracks and modulates repair at δ-electron-induced breaks

Scientific Reports
Space radiation poses a threat to human health during space missions. Its biological effect largely depends on heavy ions. These induce highly clustered DNA damage along their tracks, which is difficult to repair. If this damage is not repaired correctly,
Laura Schwan, Nicole B. Averbeck, Marco Durante, Burkhard Jakob   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The role of DNA polymerase I in tolerating single-strand breaks generated at clustered DNA damage in Escherichia coli

Scientific Reports
Clustered DNA damage, when multiple lesions are generated in close proximity, has various biological consequences, including cell death, chromosome aberrations, and mutations. It is generally perceived as a hallmark of ionizing radiation.
Naoya Shikazono, Ken Akamatsu
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

CANNOT READ--DAMAGE

The digitization of this collection was funded by a gift from EBSCO ...
CANNOT READ--DAMAGE
core   +3 more sources

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Dynamic analysis and protective structure optimization for clustered rockfall hazards triggered by the 2017 Jiuzhaigou earthquake: insights from 3D numerical modeling

Frontiers in Earth Science
IntroductionClustered rockfall hazards triggered by the 8 August 2017 Jiuzhaigou earthquake pose serious risks to infrastructure in mountainous areas.
Longfei Chen, Longfei Chen, Qiwen Lin, Qiangong Cheng, Tao Peng, Tao Peng, Linxu Liao, Bo Lv, Jincun Zhang, Xin Li   +9 more
doaj   +1 more source

Homologous Recombination Repair Mechanism in Clustered DNA Damage (18J430-FY2018)

, 2019
Compared with low let induced simple DSBs, high LET carbon beams induced cluster DSBs include different type of DNA damage: DSBs, SSBs, cross-link, base damage, etc.
821718, 821717, 821716, Chen, Qianqian, Konishi, Teruaki, 745444, 745445, 745446, 745447, 821719, 745448, Dong, Lu, 821720, Su, Fengtao   +13 more
core