Results 91 to 100 of about 161,459 (317)

Clustered DNA lesions containing 5-formyluracil and AP site: repair via the BER system.

PLoS ONE, 2013
Lesions in the DNA arise under ionizing irradiation conditions or various chemical oxidants as a single damage or as part of a multiply damaged site within 1-2 helical turns (clustered lesion).
Ekaterina A Belousova, Inna A Vasil'eva, Nina A Moor, Timofey S Zatsepin, Tatiana S Oretskaya, Olga I Lavrik   +5 more
doaj   +1 more source

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing

Frontiers in Genetics, 2021
The use of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 has moved from bench to bedside in less than 10years, realising the vision of correcting disease through genome editing. The accuracy and safety of this approach relies on
Mathilde Meyenberg, Mathilde Meyenberg, Joana Ferreira da Silva, Joana Ferreira da Silva, Joanna I. Loizou, Joanna I. Loizou   +5 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Analysis for complexity of clustered DNA damage generated by heavy ion beams [PDF]

Nucleic Acids Symposium Series, 2008
Among numerous DNA damaging factors, ionizing radiation produces the damage showing very unique structure. Since ionizing radiation passes through a target DNA as a beam, the respective induced lesions locate close together around the track. Such damage aggregation on target DNA called "clustered DNA damage" is thought to be a major cause of the ...
Hiroaki, Terato, Hiromi, Watari, Yuka, Shimazaki, Ryoichi, Hirayama, Yoshiya, Furusawa, Hiroshi, Ide   +5 more
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

High content image-based cytometry as a tool for nuclear fingerprinting [PDF]

, 2008
Cytomics aims at understanding the functional relationships between cellular phenotypes (cytome) and metabolic pathways (proteome) that result from a combination of genetically defined mechanisms (genome) and environmental conditions [1,2]. Although flow-
De Vos, Winnok, Dieriks, Birger, Joss, G, Van Oostveldt, Patric   +3 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Capsular profiling of the Cronobacter genus and the association of specific Cronobacter sakazakii and C. malonaticus capsule types with neonatal meningitis and necrotizing enterocolitis [PDF]

, 2015
Background: Cronobacter sakazakii and C. malonaticus can cause serious diseases especially in infants where they are associated with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis.
A Lehner, A Muller, A Rahman, AS Shashkov, C Iversen, C Iversen, C Whitfield, DL Daniels, E Hurrell, E Hurrell, E Jackson, E Kucerova, E Kucerova, EE Jackson, F Ramos-Morales, GI Dancer, H Kim, H Sonbol, J Caubilla-Barron, J Caubilla-Barron, J Kajimura, JR Mehall, K Butela, KA Jolley, KA Power, KG Jarvis, KG Jarvis, LL MacLean, LL MacLean, LM Willis, LS Harris, M Blažková, M Czerwicka, M Hobbs, M Scheepe-Leberkühne, MW Gilmour, N Mullane, N Navasa, NP Arbatsky, O Holy, O Holy, P. Ogrodzki, PN Danese, S Hariri, S Joseph, S Joseph, S Joseph, S Joseph, S Joseph, S Kumar, S. Forsythe, SJ Forsythe, SM Townsend, SM Townsend, T Carver, X Zogaj, Y Sun, Y Sun   +57 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Molecular profiles of single circulating tumor cells from early breast cancer patients with different lymph node statuses

Thoracic Cancer, 2023
Background Characterization of early breast cancer circulating tumor cells (CTCs) may provide valuable information on tumor metastasis. Methods We used immunomagnetic nanospheres to capture CTCs from the peripheral blood of eight early breast cancer ...
Shuyun Pang, Shu Xu, Lulu Wang, Haiping Wu, Yanan Chu, Xueping Ma, Yujiao Li, Bingjie Zou, Shaohua Wang, Guohua Zhou   +9 more
doaj   +1 more source