Order effect of repair processes to clustered DNA damage [PDF]
J Radiat Res, 2014 In a living cell, a multiply damaged site in DNA is thought to be processed by several different pathways simultaneously or sequentially. Under this situation, the cellular response to the lesion cluster might depend on the order of repair processes because the configuration of the lesions will be modified by the reaction of initial repair protein ...
Shiraishi I +4 more
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Delayed repair of radiation induced clustered DNA damage: friend or foe?
Mutat Res, 2011 A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand breaks (DSB) with associated base lesions or abasic (AP) sites, and non-DSB clusters comprised of base ...
Eccles LJ, O'Neill P, Lomax ME.
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The role of DNA polymerase I in tolerating single-strand breaks generated at clustered DNA damage in Escherichia coli [PDF]
Scientific ReportsClustered DNA damage, when multiple lesions are generated in close proximity, has various biological consequences, including cell death, chromosome aberrations, and mutations. It is generally perceived as a hallmark of ionizing radiation.
Naoya Shikazono, Ken Akamatsu
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High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core DSB response specific to clastogenic treatments. [PDF]
Frontiers in Plant Science, 2014 Plants exhibit a robust transcriptional response to gamma radiation which includes the induction of transcripts required for homologous recombination and the suppression of transcripts that promote cell cycle progression.
Victor eMissirian +4 more
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Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy. [PDF]
Proc Natl Acad Sci U S A, 2022 Nakano T +8 more
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Quantifying DNA strand breaks from targeted alpha emitters 225Ac and 227Th via Geant4-DNA: implications for RBE and cell survival [PDF]
EJNMMI PhysicsBackground Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like 225Ac and 227Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage.
Samaneh Zolghadri +2 more
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Base-excision repair increases DNA double-strand break clustering within heavy-ion tracks and modulates repair at δ-electron-induced breaks [PDF]
Scientific ReportsSpace radiation poses a threat to human health during space missions. Its biological effect largely depends on heavy ions. These induce highly clustered DNA damage along their tracks, which is difficult to repair. If this damage is not repaired correctly,
Laura Schwan +3 more
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Impact of ionizing radiation and low-energy electrons on DNA functionality: radioprotection and radiosensitization potential of natural products [PDF]
Journal of Genetic Engineering and BiotechnologyIonizing radiation (IR) is a key cancer treatment, but its DNA-damaging effects, particularly double-strand breaks (DSBs) and clustered lesions, pose challenges for therapy.
Kouass Sahbani Saloua, Rayan M. Alansari
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Clustered DNA Damage Patterns after Proton Therapy Beam Irradiation Using Plasmid DNA. [PDF]
Int J Mol Sci, 2022 Modeling ionizing radiation interaction with biological matter is a major scientific challenge, especially for protons that are nowadays widely used in cancer treatment. That presupposes a sound understanding of the mechanisms that take place from the early events of the induction of DNA damage. Herein, we present results of irradiation-induced complex
Souli MP +9 more
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The Influence of 5',8-Cyclo-2'-deoxypurines on the Mitochondrial Repair of Clustered DNA Damage in Xrs5 Cells: The Preliminary Study. [PDF]
Molecules, 2021 Boguszewska K +2 more
europepmc +3 more sources