Results 21 to 25 of about 144,547 (25)

Designing a single-molecule biophysics tool for characterizing DNA damage for techniques that kill infectious pathogens through DNA damage effects [PDF]

arXiv, 2016
Antibiotics such as the quinolones and fluoroquinolones kill bacterial pathogens ultimately through DNA damage. They target the essential type IIA topoisomerases in bacteria by stabilising the normally transient double strand break state which is created to modify the supercoiling state of the DNA.
arxiv  

Simulation and Experimental Verification of DNA Damage Due to X-Rays Interaction [PDF]

arXiv, 2018
This paper describes the model for DNA in MATLAB taking into account all of component atoms. In this model, it is possible to generate sequences with length 10000 basis pairs available for introducing all types of sequences. Once the strands are generated, it is studied the DNA damage in the single strand and double strand.
arxiv  

Ion irradiation induced direct damage to proteins and their components [PDF]

arXiv, 2008
In our last paper, we have reported the direct interact between energetic ions and DNA, and its components, pointing out that damage to DNA is actually of highest biological consequence, as the integrity of DNA sequence is essential for biological function. Proteins are another kind of important biomolecules.
arxiv  

Double-Strand Break Clustering: An Economical and Effective Strategy for DNA Repair [PDF]

arXiv
In mammalian cells, repair centers for DNA double-strand breaks (DSBs) have been identified. However, previous researches predominantly rely on methods that induce specific DSBs by cutting particular DNA sequences. The clustering and its spatiotemporal properties of non-specifically DSBs, especially those induced by environmental stresses such as ...
arxiv  

Beyond the Alphabet: Deep Signal Embedding for Enhanced DNA Clustering [PDF]

arXiv
The emerging field of DNA storage employs strands of DNA bases (A/T/C/G) as a storage medium for digital information to enable massive density and durability. The DNA storage pipeline includes: (1) encoding the raw data into sequences of DNA bases; (2) synthesizing the sequences as DNA \textit{strands} that are stored over time as an unordered set; (3)
arxiv