Formation of Clustered DNA Damage after High-LET Irradiation: A Review [PDF]
Journal of Radiation Research, 2008 Radiation can cause as well as cure cancer. The risk of developing radiation-induced cancer has traditionally been estimated from cancer incidence among survivors of the atomic bombs in Hiroshima and Nagasaki.(1)) These data provide the best estimate of human cancer risk over the dose range for low linear energy transfer (LET) radiations, such as X- or
Megumi Hada, Alexandros G. Georgakilas
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Clustered DNA damage induced by heavy ion particles
Biological Sciences in Space, 2004 Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical ...
Hiroaki Terato, Hiroshi Ide
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The Influence of Clustered DNA Damage Containing Iz/Oz and OXOdG on the Charge Transfer through the Double Helix: A Theoretical Study [PDF]
MoleculesBolesław T. Karwowski
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Deciphering repair pathways of clustered DNA damage in human TK6 cells: insights from atomic force microscopy direct visualization. [PDF]
Nucleic Acids ResNakano T +11 more
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Non-Problematic Risks from Low-Dose Radiation-Induced DNA Damage Clusters
Dose-Response, 2008 Radiation-induced DNA damage clusters have been proposed and are usually considered to pose the threat of serious biological damage. This has been attributed to DNA repair debilitation or cessation arising from the complexity of cluster damage. It will be shown here, contrary to both previous suggestions and perceived wisdom, that radiation induced ...
Daniel Hayes
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Vicinal abasic site impaired processing of a Tg:G mismatch and 8-oxoguanine lesions in three-component bistranded clustered DNA damage. [PDF]
RSC Adv, 2018 Kumari B, Jha P, Sinha KK, Das P.
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Biological Effects of Clustered DNA Damage
Japanese Journal of Health Physics, 2010 Japan Atomic Energy Agency
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Fushe yanjiu yu fushe gongyi xuebao, 2023 Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective ...
REN Junle +5 more
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Fushe yanjiu yu fushe gongyi xuebao, 2021 Five monolayer plasmid DNA films were irradiated by low-energy electrons (LEEs) (1~20 eV) in ultra-high vacuum. Crosslinks, single-strand breaks, double-strand breaks and the loss of the supercoiled configuration were analyzed via agarose gel ...
ZHUANG Puxiang +3 more
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Modeling Clustered DNA Damage by Ionizing Radiation Using Multinomial Damage Probabilities and Energy Imparted Spectra. [PDF]
Int J Mol SciSimple and complex clustered DNA damage represent the critical initial damage caused by radiation. In this paper, a multinomial probability model of clustered damage is developed with probabilities dependent on the energy imparted to DNA and surrounding water molecules.
Cucinotta FA.
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