Fluorescence anisotropy study of radiation-induced DNA damage clustering based on FRET
Analytical and Bioanalytical Chemistry, 2020A clustered DNA damage site (cluster), in which two or more lesions exist within a few helical turns, is believed to be a key factor determining the fate of a living cell exposed to a DNA damaging agent such as ionizing radiation. However, the structural details of a cluster such as the number of included lesions and their proximity are unknown. Herein,
Ken, Akamatsu +2 more
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Contribution of indirect effects to clustered damage in DNA irradiated with protons
Radiation Protection Dosimetry, 2015Protons are the dominant particles both in galactic cosmic rays and in solar particle events and, furthermore, proton irradiation becomes increasingly used in tumour treatment. It is believed that complex DNA damage is the determining factor for the consequent cellular response to radiation. DNA plasmid pBR322 was irradiated at U120-M cyclotron with 30
K, Pachnerová Brabcová +7 more
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Improvement of the local effect model (LEM)—implications of clustered DNA damage
Radiation Protection Dosimetry, 2006An improvement of the Local Effect Model (LEM) is presented which takes clustered DNA damage into account. Single strand breaks (SSBs) and double strand breaks (DSBs) are distributed stochastically onto the DNA molecule and additional DSBs are recorded.
Th, Elsässer, M, Scholz
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Clustered DNA Damage in Irradiated Human Diploid Fibroblasts: Influence of Chromatin Organization
Radiation Research, 2010Clustered DNA damages are induced by ionizing radiation and are defined as two or more lesions within one or two helical turns. The aim of this study was to investigate the induction and repair of clustered DNA damage in cells with emphasis on the influence of structural differences in the chromatin organization.
Karin, Magnander +3 more
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Clustered DNA Damages as Dosemeters for Ionising Radiation Exposure and Biological Responses
Radiation Protection Dosimetry, 2001Clustered DNA damages--two or more lesions (oxidised bases. abasic sites, or strand breaks) within a few DNA helical turns on opposing strands--are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance.
B M, Sutherland +4 more
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Investigation of Groove Damage Distribution in Proton‐Induced Clustered B‐
ABSTRACT Accurate measurement of DNA damage is critical for therapeutic optimization in proton‐based targeted radiotherapy. This research pioneered the first investigation into the groove damage distribution mechanism in clustered B‐DNA damage induced by proton radiation.
Shanshan Bao +4 more
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Processing of DNA damage clusters in human cells: current status of knowledge
Mol. BioSyst., 2008Eukaryotic cells exposed to DNA damaging agents activate important defensive pathways by inducing multiple proteins involved in DNA repair, cell cycle checkpoint control and potentially apoptosis. After the acceptance of the hypothesis that oxidatively generated clustered DNA lesions (OCDL: closely spaced DNA lesions) can be induced even by low doses ...
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Radiation therapy‐associated toxicity: Etiology, management, and prevention
Ca-A Cancer Journal for Clinicians, 2021Kyle Wang
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Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review
Ca-A Cancer Journal for Clinicians, 2022Deborah C Marshall, Mas +2 more
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Antibiotic-induced collateral damage to the microbiota and associated infections
Nature Reviews Microbiology, 2023Laura de Nies +2 more
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