Results 81 to 90 of about 577,453 (293)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Generalizations of the clustering coefficient to weighted complex networks

, 2006
The recent high level of interest in weighted complex networks gives rise to a need to develop new measures and to generalize existing ones to take the weights of links into account. Here we focus on various generalizations of the clustering coefficient,
G. Szabó, J. Scott, Jari Saramäki, Jukka-Pekka Onnela, János Kertész, Kimmo Kaski, Mikko Kivelä, S. Wasserman   +7 more
core   +1 more source

High Dimensional Apollonian Networks [PDF]

, 2005
We propose a simple algorithm which produces high dimensional Apollonian networks with both small-world and scale-free characteristics. We derive analytical expressions for the degree distribution, the clustering coefficient and the diameter of the ...
Bollt E, Doye J P K, Francesc Comellas, Guillaume Fertin, Lili Rong, Rozenfeld H, West D B, Zhang Z Z Rong L L Comellas F, Zhang Z Z Rong L L Guo C H, Zhongzhi Zhang, Zhou T Wang B H Jiang P Q Hui P M Chan K P   +10 more
core   +3 more sources

Bivariate correlation coefficients in family‐type clustered studies [PDF]

Biometrical Journal, 2015
We propose a unified approach based on a bivariate linear mixed effects model to estimate three types of bivariate correlation coefficients (BCCs), as well as the associated variances between two quantitative variables in cross‐sectional data from a family‐type clustered design. These BCCs are defined at different levels of experimental units including
Luo, Jingqin, D'Angela, Gina, Gao, Feng, Ding, Jimin, Xiong, Chengjie   +4 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Curvature of Indoor Sensor Network: Clustering Coefficient

EURASIP Journal on Wireless Communications and Networking, 2008
We investigate the geometric properties of the communication graph in realistic low-power wireless networks. In particular, we explore the concept of the curvature of a wireless network via the clustering coefficient. Clustering coefficient analysis is a
Ariaei F, Lou M, Jonckheere E, Krishnamachari B, Zuniga M   +4 more
doaj  

Deterministic weighted scale-free small-world networks

, 2010
We propose a deterministic weighted scale-free small-world model for considering pseudofractal web with the coevolution of topology and weight. In the model, we have the degree distribution exponent $\gamma$ restricted to a range between 2 and 3 ...
Andrade, Andrade, Andrade, Barabási, Barrat, Barrat, Barrat, Bollt, Comellas, Dorogovtsev, Dorogvtsev, Hinczewski, Iguchi, Jihong Guan, Jung, Karsai, Kujawski, Kwon, Leland, Lind, Maslov, Meloni, Nacher, Newman, Newman, Newman, Noh, Pastor-Satorras, Ravasz, Ravasz, Shuigeng Zhou, Song, Vázquez, Vázquez, Wang, Wang, Wu, Xie, Xu, Yan, Yang, Yichao Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhongzhi Zhang, Zhou, Zhou, Zhou, Zhou   +51 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source