Results 31 to 40 of about 103,507 (289)

Chronic Metabolic Acidosis in Chronic Kidney Disease

Kidney & Blood Pressure Research, 2020
Background: Metabolic acidosis may be diagnosed as chronic (cMA) if it persists for at least 5 days, although an exact definition has not been provided by any guidelines yet. The most common cause is CKD; numerous less-known diseases can also account for
Daniel Patschan, Susann Patschan, Oliver Ritter   +2 more
doaj   +1 more source

Adaptiveness of CMA based samplers

Proceedings of the Genetic and Evolutionary Computation Conference Companion, 2017
We turn the Covariance Matrix Adaptation Evolution Strategy into an adaptive Markov Chain Monte Carlo (or MCMC) sampling algorithm that adapts online to the target distribution, i.e. the distribution to be sampled from. We call the resulting algorithm CMA-Sampling.
Edna Milgo, Nixon K. Ronoh, Peter Waiganjo, Bernard Manderick   +3 more
openaire   +3 more sources

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation

Frontiers in Molecular Neuroscience, 2020
TAR DNA binding protein 43 kDa (TDP-43) is a ribonuclear protein regulating many aspects of RNA metabolism. Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD) are fatal neurodegenerative diseases with the presence of TDP-43 ...
Fernando Ormeño, Fernando Ormeño, Juan Hormazabal, José Moreno, Felipe Riquelme, Javiera Rios, Javiera Rios, Alfredo Criollo, Amelina Albornoz, Iván E. Alfaro, Iván E. Alfaro, Mauricio Budini, Mauricio Budini   +12 more
doaj   +1 more source

Department of State Official Business Cover Sheet

, 2006
Cover sheet: ARA/CMA to TR Martin ...
ARA/CMA
core   +3 more sources

Das Verfahren der anwendungsbegleitenden Datenerhebung für die frühe Nutzenbewertung

Monitor Versorgungsforschung
Am 16. August 2019 trat das Gesetz für mehr Sicherheit in der Arzneimittelversorgung (GSAV) in Kraft. Es wurden Änderungen in § 35a SGB V vorgenommen, die es dem Gemeinsamen Bundesausschuss (G-BA) ermöglichen, bei Arzneimitteln zur Behandlung eines ...
Dr. rer. nat. Florian Jantschak, Dr. med. Katharina Wenzel-Seifert, Dr. rer. nat. Tilman Broicher, Dr. med. Maike Schier   +3 more
doaj   +1 more source

In Vivo Remodeling of Altered Autophagy-Lysosomal Pathway by a Phosphopeptide in Lupus

Cells, 2020
The phosphopeptide P140/Lupuzor, which improves the course of lupus disease in mice and patients, targets chaperone-mediated autophagy (CMA), a selective form of autophagy that is abnormally upregulated in lupus-prone MRL/lpr mice.
Fengjuan Wang, Inmaculada Tasset, Ana Maria Cuervo, Sylviane Muller   +3 more
doaj   +1 more source

D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation

Cells, 2022
Chaperone-mediated autophagy (CMA) is a pathway in the autophagy-lysosome protein degradation system. CMA impairment has been implicated to play a role in spinocerebellar ataxia (SCA) pathogenesis. D-cysteine is metabolized by D-amino acid oxidase (DAO),
Erika Ueda, Tomoko Ohta, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki   +6 more
doaj   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source

Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression. [PDF]

PLoS ONE, 2013
V-ATPase is involved in the acidification of the microenvironment around/in solid tumors, such as oral squamous cell carcinoma (OSCC). V-ATPase is thought to induce tumor invasion and multi-drug resistance in several malignant tumors, and it also ...
Tamotsu Kiyoshima, Hisato Yoshida, Hiroko Wada, Kengo Nagata, Hiroaki Fujiwara, Makiko Kihara, Kana Hasegawa, Hirotaka Someya, Hidetaka Sakai   +8 more
doaj   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source