Results 31 to 40 of about 183,663 (250)
Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, EarlyView.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source
Online Selection of CMA-ES Variants
, 2019 In the field of evolutionary computation, one of the most challenging topics is algorithm selection. Knowing which heuristics to use for which optimization problem is key to obtaining high-quality solutions. We aim to extend this research topic by taking
Bäck, Thomas +3 more
core +1 more source
Advanced Science, EarlyView.In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang +11 more
wiley +1 more source
Advanced Science, EarlyView.We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao +23 more
wiley +1 more source
Spin relaxation signature of colossal magnetic anisotropy in platinum atomic chains
, 2016 Recent experimental data demonstrate emerging magnetic order in platinum atomically thin nanowires. Furthermore, an unusual form of magnetic anisotropy -- colossal magnetic anisotropy (CMA) -- was earlier predicted to exist in atomically thin platinum ...
Bergman, Anders +3 more
core +2 more sources
Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance
Advanced Science, EarlyView.Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes +4 more
wiley +1 more source
Photometric variability in FU Ori and Z CMa as observed by MOST [PDF]
, 2013 Photometric observations obtained by the MOST satellite were used to characterize optical small scale variability of the young stars FU Ori and Z CMa.
Guenther, David B. +8 more
core +2 more sources
Agribusiness, EarlyView.ABSTRACT Innovation is essential for competitiveness in agribusiness facing dynamic environments. This study examines how market orientation, marketing, relational, and social capabilities influence innovation performance. Using data from 751 Spanish firms and a multi‐method approach that integrates Structural Equation Modeling (PLS‐SEM), Necessary ...
Beatriz Corchuelo Martínez‐Azúa +1 more
wiley +1 more source
Star formation history of Canis Major OB1 - II. A bimodal X-ray population revealed by XMM-Newton
, 2017 The Canis Major OB1 Association has an intriguing scenario of star formation, especially in the Canis Major R1 (CMa R1) region traditionally assigned to a reflection nebula, but in reality an ionized region.
Fernandes, B. +4 more
core +2 more sources