Results 1 to 10 of about 1,561,447 (191)

Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

Nature Communications, 2022
Gomez-Sintes et al. have developed small molecules that selectively activate chaperone-mediated autophagy by stabilizing the interaction between retinoic acid receptor alpha and its co-repressor N-CoR1.
Raquel Gomez-Sintes, Qisheng Xin, Juan Ignacio Jimenez-Loygorri, Mericka McCabe, Antonio Diaz, Thomas P. Garner, Xiomaris M. Cotto-Rios, Yang Wu, Shuxian Dong, Cara A. Reynolds, Bindi Patel, Pedro de la Villa, Fernando Macian, Patricia Boya, Evripidis Gavathiotis, Ana Maria Cuervo   +15 more
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Modulating Chaperone-Mediated Autophagy and Its Clinical Applications in Cancer

Cells, 2022
Autophagy is a central mechanism for maintaining cellular homeostasis in health and disease as it provides the critical energy through the breakdown and recycling of cellular components and molecules within lysosomes.
Virginie Hubert, Sebastian Weiss, Andrew Jackson Rees, Renate Kain   +3 more
doaj   +4 more sources

Chaperone-mediated autophagy as a modulator of aging and longevity

Frontiers in Aging
Chaperone-mediated autophagy (CMA) is the lysosomal degradation of individually selected proteins, independent of vesicle fusion. CMA is a central part of the proteostasis network in vertebrate cells.
S. Joseph Endicott, S. Joseph Endicott
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Chaperone Mediated Autophagy Substrates and Components in Cancer [PDF]

Frontiers in Oncology, 2021
Chaperone-mediated autophagy (CMA) represents a specific way of lysosomal protein degradation and contrary to macro and microautophagy is independent of vesicles formation.
Javiera Rios, Alvaro Sequeida, Amelina Albornoz, Amelina Albornoz, Mauricio Budini, Mauricio Budini   +5 more
doaj   +4 more sources

Deacetylation of HSC70 by SIRT2 promotes chaperone mediated autophagy [PDF]

Autophagy Reports
Chaperone-mediated autophagy (CMA) is a selective form of lysosomal protein degradation essential for cellular proteostasis. CMA is activated during cellular stress, such as starvation, and involves the chaperone protein HSC70 (HSPA8) recognizing ...
Byunghyun Ahn, Wenzhe Chen, Wenbiao Shi, Ruben Shrestha, Fenghua Hu, Hening Lin   +5 more
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Chaperone-mediated autophagy as a regulator of hallmarks of cancer [PDF]

Frontiers in Oncology
Chaperone-mediated autophagy (CMA) is a selective lysosomal degradation pathway that maintains cellular homeostasis by degrading soluble proteins containing KFERQ-like motifs. Although CMA has traditionally been recognized for its role in protein quality
Meenakshi Tiwari, Lokendra Kumar Sharma, Bandana Chakravarti, Veena Kumari Singh, Shruti Singh, Ashutosh Shrivastava   +5 more
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Chaperone-Mediated Autophagy and Its Implications for Neurodegeneration and Cancer

International Journal of General Medicine, 2022
Masresha Ahmed Assaye,1,2 Solomon T Gizaw2 1Department of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2Department of Medical Biochemistry, School of Medicine, College of Health ...
Assaye MA, Gizaw ST
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Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA) [PDF]

Nature Communications
RNA-targeted degradation technologies offer significant promise for treating diseases by selectively disrupting gene expression. However, a robust method to specifically, efficiently, and programmability degrade targeted RNAs in mammalian cells is still ...
Hui-Ping Wen, Cong Yu, Shuli Bi, Lin-Han Jiang, Zhi-Gang Wang, Zhuhua Yao, Dai-Wen Pang, Shu-Lin Liu   +7 more
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Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery

Cell Reports, 2023
Summary: Cellular homeostasis relies on both the chaperoning of proteins and the intracellular degradation system that delivers cytoplasmic constituents to the lysosome, a process known as autophagy.
Sarah J. Backe, Rebecca A. Sager, Jennifer A. Heritz, Laura A. Wengert, Katherine A. Meluni, Xavier Aran-Guiu, Barry Panaretou, Mark R. Woodford, Chrisostomos Prodromou, Dimitra Bourboulia, Mehdi Mollapour   +10 more
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ULK1 in autophagy: sugar it up

Autophagy Reports, 2022
Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
doaj   +1 more source