Results 21 to 30 of about 1,561,447 (191)
Tracking autophagy during proliferation and differentiation of Trypanosoma brucei [PDF]
, 2014 Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Mottram, Jeremy +3 more
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Chaperone-Mediated Autophagy [PDF]
Proceedings of the American Thoracic Society, 2010 Abstract Continuous renewal of intracellular components is required to preserve cellular functionality. In fact, failure to timely turnover proteins and organelles leads often to cell death and disease. Different pathways contribute to the degradation of intracellular components in lysosomes or autophagy.
Eloy, Bejarano, Ana Maria, Cuervo
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Chaperone-mediated autophagy at a glance [PDF]
Journal of Cell Science, 2011 Chaperone-mediated autophagy (CMA) is an intracellular catabolic pathway that mediates the degradation of a selective subset of cytosolic proteins in lysosomes ([Dice, 2007][1]; [Cuervo, 2010][2]; [Kon and Cuervo, 2010][3]; [Orenstein and Cuervo, 2010][4]).
Susmita, Kaushik +8 more
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Chaperone‐mediated autophagy in health and disease [PDF]
FEBS Letters, 2009 Chaperone‐mediated autophagy (CMA) is a lysosomal pathway that participates in the degradation of cytosolic proteins. CMA is activated by starvation and in response to stressors that result in protein damage. The selectivity intrinsic to CMA allows for removal of damaged proteins without disturbing nearby functional ones.
Kon, Maria, Cuervo, Ana Maria
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Chaperone-mediated autophagy-mechanisms and disease role
, 2021 Publisher Copyright: © 2022 Elsevier Inc. All rights reserved.Autophagy is a process in which proteins and organelles are degraded via the lysosome to maintain or remodel cellular homeostasis.
Rodríguez, Christian +4 more
core +1 more source
Mutant p53 as a Regulator and Target of Autophagy
Frontiers in Oncology, 2021 One of the most notoriously altered genes in human cancer is the tumor-suppressor TP53, which is mutated with high frequency in more cancers than any other tumor suppressor gene.
Yong Shi +2 more
doaj +1 more source
Chaperone-Mediated Autophagy [PDF]
, 2008 Chaperone-mediated autophagy (CMA) is the only type of autophagy in mammalian cells able to selectively degrade cytosolic proteins in lysosomes. CMA is maximally activated in response to stressors such as prolonged starvation, exposure to toxic compounds, or oxidative stress.
S, Kaushik, A M, Cuervo
openaire +2 more sources
Analysis of Chaperone-Mediated Autophagy [PDF]
, 2019 Chaperone-mediated autophagy (CMA) is a selective type of autophagy whereby a specific subset of intracellular proteins is targeted to the lysosome for degradation. These proteins are identified by a chaperone that targets them to lysosomes. There, they are translocated into the organelle lumen through a lysosomal membrane receptor/translocation ...
Y R, Juste, A M, Cuervo
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Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]
, 2014 The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm +9 more
core +1 more source
Cell Death Discovery, 2021 Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates
Marion Bouvet +11 more
doaj +1 more source