Results 1 to 10 of about 20,722 (118)
A New Anatomy of Autophagic Clearance: On the Roles of Intrinsic Disorder in the Membrane-Less on Membrane-Encapsulated Mechanism [PDF]
MembranesAutophagy is a carefully regulated catabolic process that utilizes assemblies of specific sets of macromolecules operating at multiple stages of the pathway.
Vladimir N. Uversky +2 more
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An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy. [PDF]
PLoS ONE, 2010 Macroautophagy is a cellular process whereby the cell sequesters and recycles cytosolic constituents in a lysosome-dependent manner. It has also been implicated in a number of disorders, including cancer and neurodegeneration.
Benjamin Groves +6 more
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Frontiers in Immunology, 2022 Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since major histocompatibility complex (MHC) class II molecules sample peptides after lysosomal degradation for presentation to CD4+ T cells, it was originally described that ...
Christian Münz
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陆军军医大学学报, 2022 Objective To explore the characteristics of macroautophagy and molecular chaperone-mediated autophagy (CMA) in the oxidative stress injury of human umbilical vein endothelial cells (HUVECs).
WANG Zhengli +4 more
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Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
Biomedicines, 2021 Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles.
João Duarte Magalhães +4 more
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Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. [PDF]
PLoS Genetics, 2013 Macroautophagy is a conserved mechanism for the bulk degradation of proteins and organelles. Pathological studies have implicated defective macroautophagy in neurodegeneration, but physiological functions of macroautophagy in adult neurons remain unclear.
Keiichi Inoue +6 more
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Francisella tularensis harvests nutrients derived via ATG5-independent autophagy to support intracellular growth. [PDF]
PLoS Pathogens, 2013 Francisella tularensis is a highly virulent intracellular pathogen that invades and replicates within numerous host cell types including macrophages, hepatocytes and pneumocytes. By 24 hours post invasion, F.
Shaun Steele +5 more
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Macroautophagy abnormality in essential tremor. [PDF]
PLoS ONE, 2012 Macroautophagy is a cellular mechanism for the clearance of protein aggregates and damaged organelles. Impaired macroautophagy has been observed in neurodegenerative disorders.
Sheng-Han Kuo +8 more
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Macroautophagy and normal aging of the nervous system: Lessons from animal models
Cell Stress, 2021 Aging represents a cumulative form of cellular stress, which is thought to challenge many aspects of proteostasis. The non-dividing, long-lived neurons are particularly vulnerable to stress, and, not sur-prisingly, even normal aging is highly associated ...
Emmanouela Kallergi +1 more
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Frontiers in Immunology, 2018 Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation.
Christian Münz
doaj +1 more source