Results 1 to 10 of about 6,197 (109)

Microautophagy in Plants: Consideration of Its Molecular Mechanism

Cells, 2020
Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole.
Shino Goto-Yamada, Katarzyna Sieńko, Andisheh Poormassalehgoo   +2 more
exaly   +3 more sources

A New Anatomy of Autophagic Clearance: On the Roles of Intrinsic Disorder in the Membrane-Less on Membrane-Encapsulated Mechanism [PDF]

Membranes
Autophagy is a carefully regulated catabolic process that utilizes assemblies of specific sets of macromolecules operating at multiple stages of the pathway.
Vladimir N. Uversky, Hana Popelka, Daniel J. Klionsky   +2 more
doaj   +2 more sources

Rapamycin activates mammalian microautophagy

Journal of Pharmacological Sciences, 2019
Autophagy-lysosome proteolysis is classified into macroautophagy (MA), microautophagy (mA) and chaperone-mediated autophagy (CMA). In contrast to MA and CMA, mA have been mainly studied in yeast.
Ayumu Konno, Hirokazu Hirai, Takahiro Seki   +2 more
exaly   +3 more sources

Getting PIKy with the lysosome membrane (again) [PDF]

Autophagy Reports
Much is still unknown about microautophagy and its regulators. In our recent paper, one such regulator of microautophagy, the lipid kinase PIKfyve, is described.
Alison D. Klein, Michael Overholtzer
doaj   +2 more sources

Evidence that mitochondria in macrophages are destroyed by microautophagy [PDF]

Nature Communications
Microautophagy is an intracellular degradation process in which degradatory organelles, such as the lysosome, directly take up substrates by invagination and/or protrusion of their membranes.
Shiou-Ling Lu, Siyu Chen, Kazuya Noda, Yangjie Li, Chao-Yuan Tsai, Hiroko Omori, Yumiko Kato, Zidi Zhang, Bohan Chen, Kanako Tokuda, Tongxin Zheng, Masahiro Wakita, Eiji Hara, Mitsunori Fukuda, Yoh Wada, Eiji Morita, Narikazu Uzawa, Shinya Murakami, Takeshi Noda   +18 more
doaj   +2 more sources

A PI(3,5)P2/CHMP4B axis on lysosomes is essential for microautophagic degradation of STING [PDF]

Nature Communications
Stimulator of interferon genes (STING) is critical for the type I interferon responses to pathogen- or self-derived cytosolic DNA. STING signalling is terminated by ESCRT-driven lysosomal microautophagy.
Tsumugi Shoji, Ayumi Shinojima, Takuma Kishimoto, Kanako Sato, Nana Ikegami, Eisuke Yumoto, Ruri Shindo, Yasunori Uchida, Satoshi Kusumi, Daisuke Koga, Eiji Yamamoto, Yoshinori Hirano, Ryo Ogino, Hirofumi Shibata, Kazushi Izawa, Takahiro Yasumi, Ryota Sato, Jun Nakayama, Shigeki Higashiyama, Junya Hasegawa, Hiroaki Kajiho, Takehiko Sasaki, Yoshihiko Kuchitsu, Tomohiko Taguchi   +23 more
doaj   +2 more sources

Nuclear Microautophagy Drives Vacuolar Targeting of Yeast Iron‐Regulated Proteins During Lipid and Iron Limitation [PDF]

MicrobiologyOpen
Iron is an essential cofactor involved in cellular processes, including energy generation and the biosynthesis of DNA, proteins, and lipids. The limited solubility of iron at physiological pH frequently results in iron deficiency, thus necessitating ...
Tania Jordá, Sergi Puig
doaj   +2 more sources

Negative feedback regulation of STING signaling by TAX1BP1-directed Golgiphagy [PDF]

Nature Communications
The cGAS-STING pathway is a critical regulator of type I Interferon (IFN) and inflammation upon cytosolic DNA-sensing. cGAS-STING signaling termination is regulated by lysosomal-mediated degradation of STING; however, the mechanisms controlling the ...
Sujit Suklabaidya, Suchitra Mohanty, Irene E. Reider, Jesse White, Dominic Colter, Sarah M. McCormick, Noula Shembade, Young Bong Choi, Christopher C. Norbury, Edward W. Harhaj   +9 more
doaj   +2 more sources

MALAT1 affects atherosclerosis by regulating endothelial cell’s microautophagy [PDF]

BIO Web of Conferences, 2023
Autophagy of vessels endothelial cells is the critical pathological process in atherosclerosis (AS). Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a kind of long non-coding RNA (lncRNA) that regulates the autophagy of vessels ...
Zhang Runqi
doaj   +1 more source

Microautophagy Mediates Vacuolar Delivery of Storage Proteins in Maize Aleurone Cells

Frontiers in Plant Science, 2022
The molecular machinery orchestrating microautophagy, whereby eukaryotic cells sequester autophagic cargo by direct invagination of the vacuolar/lysosomal membrane, is still largely unknown, especially in plants.
Xinxin Ding, Xinxin Ding, Xiaoguo Zhang, Xiaoguo Zhang, Julio Paez-Valencia, Julio Paez-Valencia, Fionn McLoughlin, Francisca C. Reyes, Kengo Morohashi, Erich Grotewold, Richard D. Vierstra, Marisa S. Otegui, Marisa S. Otegui   +12 more
doaj   +1 more source