Results 11 to 20 of about 6,596 (159)

Microautophagy: definition, classification, and the complexity of the underlying mechanisms [PDF]

Autophagy
Recently, rapid progress in the field of microautophagy (MI-autophagy) revealed the existence of multiple subtypes that differ in both intracellular membrane dynamics and molecular mechanisms.
Masanori Izumi, Zhiping Xie, Masahide Oku   +2 more
exaly   +3 more sources

Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila [PDF]

Life Science Alliance, 2021
Drosophila EPS8-family protein Arouser is constitutively degraded by endosomal microautophagy; its stabilisation upon starvation is essential to the animal adaptation and survival. Hunger drives food-seeking behaviour and controls adaptation of organisms
Anne-Claire Jacomin, Raksha Gohel, Zunoon Hussain, Agnes Varga, Tamas Maruzs, Mark Eddison, Margaux Sica, Ashish Jain, Kevin G Moffat, Terje Johansen, Andreas Jenny, Gabor Juhasz, Ioannis P Nezis   +12 more
doaj   +4 more sources

AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation.

PLoS Genetics, 2019
The ubiquitin-proteasome system regulates numerous cellular processes and is central to protein homeostasis. In proliferating yeast and many mammalian cells, proteasomes are highly enriched in the nucleus.
Jianhui Li, Michal Breker, Morven Graham, Maya Schuldiner, Mark Hochstrasser   +4 more
doaj   +2 more sources

A synthetic chlorophagy receptor promotes plant fitness by mediating chloroplast microautophagy

Cell Reports
Summary: Chloroplasts are photosynthetic organelles and one of the major protein-containing organelles in green plants and algae. Although chloroplast contents or entire chloroplasts can be cleared by various vesicular pathways and autophagy, canonical ...
Rui Liu, Xun Weng, Xinjing Li, Yongheng Cao, Qiyun Li, Lin Luan, Danqing Tong, Zhaosheng Kong, Hao Wang, Taotao Wang, Qingqiu Gong   +10 more
doaj   +2 more sources

Endosomal microautophagy is activated by specific cellular stresses in trout hepatocytes

Scientific Reports
Endosomal microautophagy (eMI) is a recently discovered autophagic process where cytosolic proteins are selectively captured in late endosome/multivesicular bodies (LE/MVB).
Emilio J. Vélez, Vincent Véron, Jeanne Gouis, Steffi Reji, Karine Dias, Amaury Herpin, Florian Beaumatin, Iban Seiliez   +7 more
doaj   +2 more sources

Insights Into the Mechanisms of Biological Aging That Guide Translational and Clinical Research. [PDF]

Aging Med (Milton)
Cellular NAD+ levels can be augmented through supplementation with precursors such as nicotinamide (NAM), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN). Accumulating preclinical and clinical evidence suggests that NAD+ repletion attenuates both pathological (premature or accelerated) and chronological aging, thereby extending ...
Fang EF, Nilsen H, Scheibye-Knudsen M, Bohr VA, Kang L.   +4 more
europepmc   +2 more sources

Topology and Function of the S. cerevisiae Autophagy Protein Atg15

Cells, 2023
The putative phospholipase Atg15 is required for the intravacuolar lysis of autophagic bodies and MVB vesicles. Intracellular membrane lysis is a highly sophisticated mechanism that is not fully understood.
Lisa Marquardt, Marco Montino, Yvonne Mühe, Petra Schlotterhose, Michael Thumm   +4 more
doaj   +1 more source

The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts

eLife, 2023
The ubiquitin-binding NBR1 autophagy receptor plays a prominent role in recognizing ubiquitylated protein aggregates for vacuolar degradation by macroautophagy.
Han Nim Lee, Jenu Varghese Chacko, Ariadna Gonzalez Solís, Kuo-En Chen, Jessica AS Barros, Santiago Signorelli, A Harvey Millar, Richard David Vierstra, Kevin W Eliceiri, Marisa S Otegui   +9 more
doaj   +1 more source

Microautophagy of cytosolic proteins by late endosomes. [PDF]

, 2011
Autophagy delivers cytosolic components to lysosomes for their degradation. The delivery of autophagic cargo to late endosomes for complete or partial degradation has also been described.
Scharf B, Clement CC, Cannizzo ES, Kaushik S, Cuervo AM, Sahu R, Santambrogio L., FOLLENZI, Antonia, Nieves E, Potolicchio I   +9 more
core   +3 more sources

ESCRT machinery plays a role in microautophagy in yeast

BMC Molecular and Cell Biology, 2020
Background Microautophagy, which degrades cargos by direct lysosomal/vacuolar engulfment of cytoplasmic cargos, is promoted after nutrient starvation and the inactivation of target of rapamycin complex 1 (TORC1) protein kinase.
Shamsul Morshed, Most Naoshia Tasnin, Takashi Ushimaru   +2 more
doaj   +1 more source