Results 21 to 30 of about 6,596 (159)

Deacetylation of ATG16L1 is required for LC3-associated lysosomal microautophagy [PDF]

Autophagy
Wei Wan, Han-Ming Shen, Tianhua Zhou
exaly   +2 more sources

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma

Frontiers in Oncology, 2020
Tumor cells can employ epithelial-mesenchymal transition (EMT) or autophagy in reaction to microenvironmental stress. Importantly, EMT and autophagy negatively regulate each other, are able to interconvert, and both have been shown to contribute to drug ...
Bárbara Paranhos Coelho, Camila Felix de Lima Fernandes, Jacqueline Marcia Boccacino, Maria Clara da Silva Souza, Maria Isabel Melo-Escobar, Rodrigo Nunes Alves, Mariana Brandão Prado, Rebeca Piatniczka Iglesia, Giovanni Cangiano, Giulia La Rocca Mazzaro, Marilene Hohmuth Lopes   +10 more
doaj   +1 more source

TORC1 specifically inhibits microautophagy through ESCRT-0 [PDF]

, 2019
Nutrient starvation induces the degradation of specific plasma membrane proteins through the multivesicular body (MVB) sorting pathway and of vacuolar membrane proteins through microautophagy. Both of these processes require the gateway protein Vps27,
Hatakeyama, Riko, Virgilio, Claudio De, De Virgilio, Claudio   +2 more
core   +1 more source

Targeted for destruction: degradation of singlet oxygen-damaged chloroplasts

Plant Signaling & Behavior, 2022
Photosynthesis is an essential process that plants must regulate to survive in dynamic environments. Thus, chloroplasts (the sites of photosynthesis in plant and algae cells) use multiple signaling mechanisms to report their health to the cell.
Matthew D. Lemke, Jesse D. Woodson
doaj   +1 more source

AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation

eLife, 2017
Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability are unclear. We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells ...
Arnold Y Seo, Pick-Wei Lau, Daniel Feliciano, Prabuddha Sengupta, Mark A Le Gros, Bertrand Cinquin, Carolyn A Larabell, Jennifer Lippincott-Schwartz   +7 more
doaj   +1 more source

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy [PDF]

, 2015
SummarySynapses are often far from their cell bodies and must largely independently cope with dysfunctional proteins resulting from synaptic activity and stress.
Kuenen, Sabine, Melo, Manuel N., Sabine Kuenen, Miskiewicz, Katarzyna, Patrik Verstreken, Sebastian Munck, Wittocx, Rafa??l, Lauwers, Elsa, Munck, Sebastian, Valerie Uytterhoeven, Swerts, Jef, Jef Swerts, Corthout, Nikky, Maes, Ine, Katarzyna Miskiewicz, Marrink, Siewert-Jan, Uytterhoeven, Valerie, Ine Maes, Marrink, Siewert-jan; id_orcid, Siewert-Jan Marrink, Wittocx, Rafaël, Manuel N. Melo, Rafaël Wittocx, Elsa Lauwers, Verstreken, Patrik, Nikky Corthout   +25 more
core   +2 more sources

Membrane recruitment of Atg8 by Hfl1 facilitates turnover of vacuolar membrane proteins in yeast cells approaching stationary phase

BMC Biology, 2021
Background The vacuole/lysosome is the final destination of autophagic pathways, but can also itself be degraded in whole or in part by selective macroautophagic or microautophagic processes.
Cheng-Wen He, Xue-Fei Cui, Shao-Jie Ma, Qin Xu, Yan-Peng Ran, Wei-Zhi Chen, Jun-Xi Mu, Hui Li, Jing Zhu, Qingqiu Gong, Zhiping Xie   +10 more
doaj   +1 more source

Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 Inflammasome for Self-Rescue

Biomolecules, 2022
Atherosclerosis (AS) is a lipid-driven disorder of the artery intima characterized by the equilibrium between inflammatory and regressive processes. A protein complex called NLRP3 inflammasome is involved in the release of mature interleukin-1β (IL-1β ...
Xuelian Li, Xianjie Zhu, Yumiao Wei
doaj   +1 more source

Advance of autophagy in chronic kidney diseases

Renal Failure, 2017
Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues and experimental animal models implicate that autophagy
Xu Deng, Yifan Xie, Aihua Zhang
doaj   +1 more source

Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy

Cell Reports, 2023
Summary: Chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI) are pathways for selective degradation of cytosolic proteins in lysosomes and late endosomes, respectively. These autophagic processes share as a first step the recognition of
Gregory J. Krause, Philipp Kirchner, Barbara Stiller, Kateryna Morozova, Antonio Diaz, Kuei-Ho Chen, Nevan J. Krogan, Esperanza Agullo-Pascual, Cristina C. Clement, Kristen Lindenau, Danielle L. Swaney, Shilpa Dilipkumar, Jose Javier Bravo-Cordero, Laura Santambrogio, Ana Maria Cuervo   +14 more
doaj   +1 more source