Results 31 to 40 of about 6,596 (159)

ULK1 in autophagy: sugar it up

Autophagy Reports, 2022
Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
doaj   +1 more source

Safeguarding Lysosomal Homeostasis by DNAJC5/CSPα-Mediated Unconventional Protein Secretion and Endosomal Microautophagy

Frontiers in Cell and Developmental Biology, 2022
Neuronal ceroid lipofuscinosis (NCL) is a collection of genetically inherited neurological disorders characterized by vision loss, seizure, brain death, and premature lethality.
Juhyung Lee, Yue Xu, Yihong Ye
doaj   +1 more source

Lipid droplets in stress protection: distinct mechanisms of lipid droplet microautophagy

Autophagy Reports, 2022
Lipid droplets (LDs) are organelles that function as sites for lipid storage. LDs have also been implicated in the cellular response to proteotoxic or lipotoxic stress as sites for sequestering dysfunctional or excess proteins or lipids, and targeting ...
Pin-Chao Liao, Liza A. Pon
doaj   +1 more source

Eating Locally: Microautophagy and Protein Turnover at the Synapse [PDF]

, 2015
Mechanisms of local protein quality control in the presynaptic nerve terminal remain largely unknown. In this issue of Neuron, Uytterhoeven et al. (2015) describe a form of synaptic endosomal microautophagy controlling protein rejuvenation, critical for ...
McPherson, Peter S.
core   +1 more source

ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates [PDF]

Journal of Cell Biology
Yusuke Sato, Shigeo Murata, Shoshiro Hirayama   +2 more
exaly   +2 more sources

Sucrose Starvation Induces Microautophagy in Plant Root Cells

Frontiers in Plant Science, 2019
Autophagy is an essential system for degrading and recycling cellular components for survival during starvation conditions. Under sucrose starvation, application of a papain protease inhibitor E-64d to the Arabidopsis root and tobacco BY-2 cells induced ...
Shino Goto-Yamada, Kazusato Oikawa, Jakub Bizan, Shuji Shigenobu, Shuji Shigenobu, Katsushi Yamaguchi, Shoji Mano, Shoji Mano, Makoto Hayashi, Haruko Ueda, Ikuko Hara-Nishimura, Mikio Nishimura, Kenji Yamada   +12 more
doaj   +1 more source

Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

eLife, 2017
Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which transport cholesterol from the lumen of lysosomes to the limiting membrane of that compartment.
Takuma Tsuji, Megumi Fujimoto, Tsuyako Tatematsu, Jinglei Cheng, Minami Orii, Sho Takatori, Toyoshi Fujimoto   +6 more
doaj   +1 more source

Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy

Cells, 2022
Autophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation.
Simon Schnebert, Maxime Goguet, Emilio J. Vélez, Alexandra Depincé, Florian Beaumatin, Amaury Herpin, Iban Seiliez   +6 more
doaj   +1 more source

Microautophagy in the Yeast Saccharomyces cerevisiae

, 2008
Microautophagy involves direct invagination and fission of the vacuolar/lysosomal membrane under nutrient limitation. In Saccharomyces cerevisiae microautophagic uptake of soluble cytosolic proteins occurs via an autophagic tube, a highly specialized ...
Andreas Uttenweiler, Andreas Mayer, Uttenweiler, A., Mayer, A.   +3 more
core   +1 more source

Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

The Journal of Clinical Investigation, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants.
Guoli Shi, Abhilash I. Chiramel, Tiansheng Li, Kin Kui Lai, Adam D. Kenney, Ashley Zani, Adrian C. Eddy, Saliha Majdoul, Lizhi Zhang, Tirhas Dempsey, Paul A. Beare, Swagata Kar, Jonathan W. Yewdell, Sonja M. Best, Jacob S. Yount, Alex A. Compton   +15 more
doaj   +1 more source