Results 41 to 50 of about 24,501 (174)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Genetic aberrations in macroautophagy genes leading to diseases [PDF]

, 2018
The catabolic process of macroautophagy, through the rapid degradation of unwanted cellular components, is involved in a multitude of cellular and organismal functions that are essential to maintain homeostasis.
Klionsky, Daniel J, Daniel J. Klionsky, Reggiori, Fulvio, van Beek, Nienke, Nienke van Beek, Fulvio Reggiori   +5 more
core   +2 more sources

Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis

Molecular Therapy: Oncolytics, 2021
Metabolic reprogramming is a core hallmark of cancer and is key for tumorigenesis and tumor progression. Investigation of metabolic perturbation by anti-cancer compounds would allow a thorough understanding of the underlying mechanisms of these agents ...
Dan Liu, Xing Jin, Guanzhen Yu, Mingsong Wang, Lei Liu, Wenjuan Zhang, Jia Wu, Fengying Wang, Jing Yang, Qin Luo, Lili Cai, Xi Yang, Xisong Ke, Yi Qu, Zhenye Xu, Lijun Jia, Wen-Lian Chen   +16 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death [PDF]

, 2022
Although macroautophagy deficits are implicated across adult-onset neurodegenerative diseases, we understand little about how the discrete, highly evolved cell types of the central nervous system use macroautophagy to maintain homeostasis.
Li, Alice M., Goldman, James E., Yamamoto, Ai, Young Joo Yang, Christopher J. Griffey, Grutzendler, Jaime, Yang, Young Joo, Julie C. Canman, Alice M. Li, Jaime Grutzendler, James E. Goldman, Etan R. Aber, Katherine R. Croce, Davies, Tim, Tim Davies, Croce, Katherine R., Canman, Julie C., Aber, Etan R., Griffey, Christopher J., Ai Yamamoto   +19 more
core   +1 more source

Functional inhibition of heat shock protein 70 by VER‐155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism

Thoracic Cancer, 2021
Background: Pleural mesothelioma, a devastating asbestos‐associated malignancy, urgently requires a novel effective therapy. Heat shock protein 70 (HSP70), which is synthesized in the cell response to protein damage, is expected to be a new target for ...
Kosuke Sakai, Maya Inoue, Shintaro Mikami, Hiroaki Nishimura, Yoshiki Kuwabara, Akitoshi Kojima, Maiko Toda, Yumiko Ogawa‐Kobayashi, Satoshi Kikuchi, Yusuke Hirata, Yuriko Mikami‐Saito, Hiroyuki Kyoyama, Gaku Moriyama, Michio Shiibashi, Masahiro Seike, Akihiko Gemma, Kazutsugu Uematsu   +16 more
doaj   +1 more source

Presynaptic Autophagy and the Connection With Neurotransmission

Frontiers in Cell and Developmental Biology, 2021
Autophagy is an evolutionary conserved catabolic pathway essential for the maintenance of cellular homeostasis. Defective proteins and organelles are engulfed by autophagosomal membranes which fuse with lysosomes for cargo degradation.
Marianna Decet, Marianna Decet, Patrik Verstreken, Patrik Verstreken   +3 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Nutrient control of macroautophagy in mammalian cells.

, 2006
A growing number of evidences indicate a strict causality between the reduction of autophagic functionality and aging. In this context the preservation of a proper autophagic response is of paramount importance to preserve the cellular processes in aging
KARIM MR, CARPI A., KADOWAKI M, MIOTTO, GIOVANNI   +3 more
core   +1 more source